Preparation and Anti-Tumor Activity of Polysaccharides from <i>Phellinus pini</i> Mycelia

Abstract

Polysaccharides PSIand PSIIwere isolated from liquid-cultured mycelia of Phellinus pini. The average molecular weight: PSI36 kDa, PSII49 kDa; sulfate content: PSI5.25%, PSII0.65%; monosaccharide composition: PSIglucose, galactose and mannitose; PSIIglucose, mannitose and xylose. Anti-tumor activities of PSIand PSII(400 mg/kg·d, i.g.) were investigated in S180-bearing mice. Results indicated that PSIand PSIIsignificantly inhibited the growth of S180-solid tumors. PSIand PSIIeffectively protected immune organs (thymus and spleen) and increased activities of immune cells (NK cells, macrophages, T and B lymphocytes). Results suggest that polysaccharides PSIand PSIIfrom Phellinus pini have potential anti-tumor activities, which might attributed partly to their immunomodulatory properties.

Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species

“…P. pini and P. igniarius are members of Phellinus species have been reported as medicinal mushrooms in China, Japan, and Korea (Ajith & Janardhanan, ). In recent years, numerous studies have demonstrated that polysaccharides isolated from P. pini and P. igniarius displayed antioxidant and antitumor activities (Jiang, Yuan, Cai, Jiao, & Zhang, ; Li, Yang, Ma, Yan, & Guo, ; Liu et al, ; Yuan et al, ). G. adspersum , G. lucidum, and G. applanatum belongs to Ganoderma species, which is considered as an important source of bioactive compounds in worldwide (Ferreira et al, ; Tel‐Çayan et al, ).…”