Preparation and antibacterial activity of silver-loaded poly(oligo(ethylene glycol) methacrylate) brush

Zou, Xue-Na; Han, Xiao; Zhang, Qian; Yin, Jun-Jiao; Chu, Li‐Qiang

doi:10.1080/09205063.2019.1603066

Cited by 3 publications

(2 citation statements)

References 46 publications

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Section: Introductionmentioning

confidence: 99%

“…Raman spectroscopy has previously been used to characterize several thermoresponsive polymers at their transition temperatures, including PNIPAM [11,16]; however, no such characterizations exist for the conformational change/phase transition of POEGMA, to the authors' knowledge. Previous studies showed Raman spectroscopy being utilized to confirm the incorporation of silver nanoparticles into anti-fouling POEGMA brushes for analyzing enhanced antibacterial activities rather than for characterization of conformational changes of the polymer itself [17,18]. In the study reported here, we synthesized POEGMA-144 brushes on silica nanoparticles (SNPs) and conducted Raman spectroscopy in a temperature range across its LCST to characterize the conformational collapse and Although the bulk conformational change of POEGMA brushes have been previously characterized by our group via a photonic crystal biosensor, as well as by other groups with mechanisms such as atomic force microscopy (AFM) and quartz crystal microbalance dissipation (QCM-D) [3,[5][6][7]12], the corresponding molecular change associated with the conformational change is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Characterizing Conformational Change of a Thermoresponsive Polymeric Nanoparticle with Raman Spectroscopy

Trabucco

Heath

Shaw

et al. 2023

Sensors

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Molecular conformational changes in the collapsing and reswelling processes occurring during the phase transition at the lower critical solution temperature (LCST) of the polymer are not well understood. In this study, we characterized the conformational change of Poly(oligo(Ethylene Glycol) Methyl Ether Methacrylate)-144 (POEGMA-144) synthesized on silica nanoparticles using Raman spectroscopy and zeta potential measurements. Changes in distinct Raman peaks associated with the oligo(Ethylene Glycol) (OEG) side chains (1023, 1320, and 1499 cm−1) with respect to the methyl methacrylate (MMA) backbone (1608 cm−1) were observed and investigated under increasing and decreasing temperature profiles (34 °C to 50 °C) to evaluate the polymer collapse and reswelling around its LCST (42 °C). In contrast to the zeta potential measurements that monitor the change in surface charges as a whole during the phase transition, Raman spectroscopy provided more detailed information on vibrational modes of individual molecular moieties of the polymer in responding to the conformational change.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterizing Conformational Change of a Thermoresponsive Polymeric Nanoparticle with Raman Spectroscopy

Trabucco

Heath

Shaw

et al. 2023

Sensors

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Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications

Alex

Gautrot

2021

Soft Matter for Biomedical Applications

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Polymer brushes allow the surface functionalisation of a wide range of substrates with polymer chains with controlled chemistry, therefore enabling the precise control of physico-chemical properties of corresponding interfaces. Such level of control has clear implications for the design of biomaterials, implants, scaffolds and devices in the biomedical field. For example, this enables the regulation of protein adsorption and the biofunctionalisation of biomaterials to promote cell adhesion, regulate signalling, confer bactericidal properties or targeting of specific cells or tissues. In addition, the temperature- and salt-responsive properties of some polymer brushes enable the capture and controlled release of therapeutics, including for gene delivery applications. Importantly, such control of surface chemistry can be achieved independently of the inherent properties and chemistry of the core substrate, whether it is an implant, scaffold or nanoparticle. Indeed, synthetic approaches to the tethering of polymer brushes are particularly versatile. In this chapter, we review recent progress in the design of polymer brushes in the biomedical field.

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Structure and transition behavior of crosslinked poly(2-(2-methoxyethoxy) ethylmethacrylate-co-(ethyleneglycol) methacrylate) gel film on cellulosic-based flat substrate

Chen,

Su,

Zhou

et al. 2024

E-Polymers

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The structure and transition behavior of crosslinked thermo-responsive poly(2-(2-methoxyethoxy) ethylmethacrylate-co-(ethyleneglycol) methacrylate) (P(MEO2MA-co-EGMA360)) gel film on a flat cellulosic-based substrate were investigated. The regenerated cellulose (RC) film was prepared by spin-coating with trimethylsilyl cellulose (TMSC), followed by etching with hydrochloric acid vapor on a treated silicon wafer, then crosslinked polymer gel film was obtained by spin-coating, drying, and baking with a pre-crosslinked solution containing polymers. Fourier transform infrared spectroscopy, X-ray photoelectron spectrometer, and atomic force microscopy results show that a RC film with a thickness of 25 nm is generated in the upper layer of TMSC film on the silicon wafer. The cross-linking induces closer arrangement and hinders the extension of chain segments, leading to less prominent phase transition behaviors of polymer gel films. By quartz crystal microbalance measurement and 3D microscopes, a phase transition hysteresis is discovered, the hydrated and loose structure of crosslinked polymer gel film switches to dehydrated and compact structure in initial heating process, which subsequently recovers during the following cooling process. However, the degrees of rehydration and flexibility of film could not reach the initial value because of the insufficient transition time and steric hindrance caused by crosslinking.

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Preparation and antibacterial activity of silver-loaded poly(oligo(ethylene glycol) methacrylate) brush

Cited by 3 publications

References 46 publications

Characterizing Conformational Change of a Thermoresponsive Polymeric Nanoparticle with Raman Spectroscopy

Characterizing Conformational Change of a Thermoresponsive Polymeric Nanoparticle with Raman Spectroscopy

Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications

Structure and transition behavior of crosslinked poly(2-(2-methoxyethoxy) ethylmethacrylate-co-(ethyleneglycol) methacrylate) gel film on cellulosic-based flat substrate

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