Preparation and Antimicrobial Activity of Inorganic Nanoparticles

Boboc, Marius; Curti, Filis; Fleacă, Amalia M.; Jianu, Mădălina L.; Rosu, A.F.; Curuţiu, Carmen; Lazăr, Veronica; Chifiriuc, Mariana Carmen; Grumezescu, Alexandru Mihai

doi:10.1016/b978-0-323-46152-8.00014-7

Cited by 8 publications

(5 citation statements)

References 70 publications

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“…Therefore, developing new agents with alternative mechanisms of action against the current foodborne bacterial pathogens is crucially needed. Currently, inorganic NPs (silver, zinc oxide, gold, selenium, magnesium oxide, and iron oxide) are being increasingly studied for their antibacterial properties and potential applications in biomedicine [ 61 ] and the food industry [ 62 ], along with minimizing treatment durations, side effects, and antimicrobial resistance [ 63 ]. Knowing alternative antimicrobial agents and their unique mechanisms of action against potential foodborne bacterial pathogens and their toxins is useful as a guide for both governmental and nongovernmental policymakers and stakeholders to control food-related diseases.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity and Mechanisms of Action of Inorganic Nanoparticles against Foodborne Bacterial Pathogens: A Systematic Review

Girma,

Abera,

Mekuye

et al. 2024

IET Nanobiotechnology

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Foodborne disease outbreaks due to bacterial pathogens and their toxins have become a serious concern for global public health and security. Finding novel antibacterial agents with unique mechanisms of action against the current spoilage and foodborne bacterial pathogens is a central strategy to overcome antibiotic resistance. This study examined the antibacterial activities and mechanisms of action of inorganic nanoparticles (NPs) against foodborne bacterial pathogens. The articles written in English were recovered from registers and databases (PubMed, ScienceDirect, Web of Science, Google Scholar, and Directory of Open Access Journals) and other sources (websites, organizations, and citation searching). “Nanoparticles,” “Inorganic Nanoparticles,” “Metal Nanoparticles,” “Metal–Oxide Nanoparticles,” “Antimicrobial Activity,” “Antibacterial Activity,” “Foodborne Bacterial Pathogens,” “Mechanisms of Action,” and “Foodborne Diseases” were the search terms used to retrieve the articles. The PRISMA-2020 checklist was applied for the article search strategy, article selection, data extraction, and result reporting for the review process. A total of 27 original research articles were included from a total of 3,575 articles obtained from the different search strategies. All studies demonstrated the antibacterial effectiveness of inorganic NPs and highlighted their different mechanisms of action against foodborne bacterial pathogens. In the present study, small-sized, spherical-shaped, engineered, capped, low-dissolution with water, high-concentration NPs, and in Gram-negative bacterial types had high antibacterial activity as compared to their counterparts. Cell wall interaction and membrane penetration, reactive oxygen species production, DNA damage, and protein synthesis inhibition were some of the generalized mechanisms recognized in the current study. Therefore, this study recommends the proper use of nontoxic inorganic nanoparticle products for food processing industries to ensure the quality and safety of food while minimizing antibiotic resistance among foodborne bacterial pathogens.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Activity and Mechanisms of Action of Inorganic Nanoparticles against Foodborne Bacterial Pathogens: A Systematic Review

Girma,

Abera,

Mekuye

et al. 2024

IET Nanobiotechnology

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“…Inorganic nanomaterials have garnered significant attention as they are an effective treatment for wound healing. They can deliver therapeutic agents in a controlled manner [50] or display intrinsic properties, such as antibacterial [51,52], anti-inflammatory [53], antioxidant [54], and angiogenesis-promoting abilities [55], to act as a therapeutic agent. Because of their small size and high surface-area-to-volume ratio, nanoparticles can be used to enhance the effectiveness of wound healing treatments.…”

Section: Application Of Inorganic Nanomaterials For Wound Healingmentioning

confidence: 99%

Inorganic-Nanomaterial-Composited Hydrogel Dressings for Wound Healing

Yang,

Wang,

Zhang

et al. 2024

J. Compos. Sci.

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Wound management heavily relies on the vital contribution of wound dressings, emphasizing the significance of finding an ideal dressing that can fulfill the intricate requirements of the wound healing process with multiple functions. A promising strategy is combining several materials and therapies to create multifunctional wound dressings. Nanocomposite hydrogel dressings based on nanomaterials, combining the advantages of nanomaterials and hydrogels in wound treatment, can significantly improve their respective performance and compensate for their shortcomings. A variety of nanocomposite wound dressings with diverse structures and synergistic functions have been developed in recent years, achieving ideal results in wound management applications. In this review, the multiple functions, advantages, and limitations of hydrogels as wound dressings are first discussed. Additionally, the application of inorganic nanomaterials in wound healing is also elaborated on. Furthermore, we focused on summarizing and analyzing nanocomposite hydrogel dressings for wound healing, which contain various inorganic nanomaterials, including metals, metal oxides, metal sulfides, carbon-based nanomaterials, and silicon-based nanoparticles. Finally, prospects for nanocomposite hydrogel wound dressings are envisaged, providing insights for further research in wound management.

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“…These NPs include metal and metal oxide NPs which can be synthesized from metals such as gold (Au), silver (Ag), copper (Cu), and/or aluminum (Al) NPs, metal oxides such as iron oxide, magnesium oxide (MgO), titanium oxide (TiO 2 ) and zinc oxide (ZnO) NPs, and semiconductors such as silicon and ceramics [ 18 ]. Inorganic NPs can withstand harsh process conditions and have been considered safe materials for humans and animals [ 19 ]. The antimicrobial effect of these NPs depends on certain characteristics such as size, shape, ζ-potential, ligands, pH, roughness, stability, crystal structure, and material used, but the relationship between these characteristics and their antimicrobial ability is not well-understood to date [ 20 , 21 ].…”

Section: Nanoparticles Types and Their Usesmentioning

confidence: 99%

“…These NPs are made mostly from organic matter. Organic NPs are less stable than inorganic ones, especially at high temperatures and/or pressures [ 19 ], but otherwise show excellent biocompatibility, stability, targeting efficiency, and low-hydro-soluble drug storage [ 27 , 28 ]. They represent more than two-thirds of the nano-systems [ 20 , 29 ].…”

Section: Nanoparticles Types and Their Usesmentioning

confidence: 99%

Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment

2021

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Infectious diseases hold third place in the top 10 causes of death worldwide and were responsible for more than 6.7 million deaths in 2016. Nanomedicine is a multidisciplinary field which is based on the application of nanotechnology for medical purposes and can be defined as the use of nanomaterials for diagnosis, monitoring, control, prevention, and treatment of diseases, including infectious diseases. One of the most used nanomaterials in nanomedicine are nanoparticles, particles with a nano-scale size that show highly tunable physical and optical properties, and the capacity to a wide library of compounds. This manuscript is intended to be a comprehensive review of the available recent literature on nanoparticles used for the prevention and treatment of human infectious diseases caused by different viruses, and bacteria from a clinical point of view by basing on original articles which talk about what has been made to date and excluding commercial products, but also by highlighting what has not been still made and some clinical concepts that must be considered for futures nanoparticles-based technologies applications.

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Preparation and Antimicrobial Activity of Inorganic Nanoparticles

Cited by 8 publications

References 70 publications

Antibacterial Activity and Mechanisms of Action of Inorganic Nanoparticles against Foodborne Bacterial Pathogens: A Systematic Review

Antibacterial Activity and Mechanisms of Action of Inorganic Nanoparticles against Foodborne Bacterial Pathogens: A Systematic Review

Inorganic-Nanomaterial-Composited Hydrogel Dressings for Wound Healing

Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment

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