Preparation and Antimicrobial Activity of Antibacterial Silver-Loaded Polyphosphazene Microspheres

Abstract

Poly(cyclotriphosphazene-co-4,4’-diaminodiphenyl ether) (PPO) microspheres were prepared via a precipitation polymerization method, using hexachlorocyclotriphosphazene (HCCP) and 4,4’-diaminodiphenyl ether (ODA) as monomers. Silver-loaded PPO (PPOA) microspheres were generated by the in situ loading of silver nanoparticles onto the surface by Ag+ reduction. Our results showed that PPOA microspheres were successfully prepared with a relatively uniform distribution of silver nanoparticles on microsphere surfaces. PPOA microspheres had good thermal stability and excellent antibacterial activity towards Escherichia coli and Staphylococcus aureus. Furthermore, PPOA microspheres exhibited lower cytotoxicity when compared to citrate-modified silver nanoparticles (c-Ag), and good sustained release properties. Our data indicated that polyphosphazene-based PPOA microspheres are promising antibacterial agents in the biological materials field.

Preparation strategy of hydrogel microsphere and its application in skin repair

“…The hydrogel microspheres exhibited negligible damage to cells and accelerated the skin repair of a variety of acute and chronic wounds. In addition, polycyclic triphosphonitrile-co-4,4′-diaminodiphenyl ether (PPO) hydrogel microspheres were prepared by precipitation polymerization using HCCP and 4,4′-diaminodiphenyl ether (ODA) as monomers ( Long H. et al, 2021 ). Silver ion (Ag + )-loaded PPO (PPOA) hydrogel microspheres were prepared by in-situ load silver nanoparticles onto the surface of hydrogel microsphere.…”

Phosphazene Cyclomatrix Network-Based Polymer: Chemistry, Synthesis, and Applications

“…Opposite to this, fluorescent active species can be used and easily prepared by the self-assembly method. These active fluorescent methods possesses the intrinsic optical features due to their backbone structural stability and π–π conjugation. , In this context, various polyphosphazene polymers which possess the suitable morphology and exhibit the fluorescent properties are chosen to be used as a biosensor, detector, and biomaterial. − The poly­(cyclotriphosphazene- co -phloroglucinol) (PCTP) fluorescent microspheres, poly­(cyclotriphosphazene- co -fluorescein) (PCTPF) nanoshells, intrinsic poly­(cyclotriphosphazene- co -resveratrol) (PRS) hollow spheres, and poly­[cyclotriphosphazene- co -bis­(aminomethyl)­ferrocene] (PCPF) microspheres, and the hybrid poly­[cyclotriphosphazene- co -1,3,5-tri­(4-hydroxyphenyl)­benzene] (PCTHB) microsphere has exhibited great results as a fluorescent active and drug carrier biomaterial because of its porous nature and high surface area.…”