2022
DOI: 10.3390/separations9050111
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Preparation and Antioxidant Activities of Phenylethanoids from Dracocephalum heterophyllum

Abstract: The health benefits of Dracocephalum heterophyllum are widely reported in traditional Tibetan medicines, but the reported chemical composition is limited, probably due to difficulties in separating and purifying compounds. In this study, antioxidative phenylethanoids were isolated from an extract of Dracocephalum heterophyllum using medium- and high-pressure liquid chromatography, coupled with on-line HPLC–1,1-diphenyl-2-picrylhydrazyl recognition. Firstly, crude samples (1.3 kg) of Dracocephalum heterophyllum… Show more

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Cited by 7 publications
(9 citation statements)
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“…Our group has previously successfully completed the isolation and identification of several new active compounds [ 7 , 8 ]. Based on the previous studies, the separation method of D. heterophyllum was adjusted to some extent in this study.…”
Section: Methodsmentioning
confidence: 99%
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“…Our group has previously successfully completed the isolation and identification of several new active compounds [ 7 , 8 ]. Based on the previous studies, the separation method of D. heterophyllum was adjusted to some extent in this study.…”
Section: Methodsmentioning
confidence: 99%
“…In this method, the ability of the compound to scavenge free radicals is measured by the decrease in absorbance at 517 nm after the addition of 1,1-diphenyl-2-picrylhydrazine (DPPH) to the HPLC pathway. This method has been widely used to detect the presence of various antioxidants in many plants and foods, and it has screened several new active compounds with antioxidant activity [ 7 , 8 ]. In addition, one of the best chromatographic methods currently available for the extraction of single compounds from complex samples is preparative HPLC, which has the advantages of good separation, real-time monitoring, and high reproducibility [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“….75 (1H, d, J ¼ 1.9 Hz, 2 ′ -H), 6.64 (1H, d, J ¼ 8.0 Hz, 5 ′ -H), 6.56 (1H, dd, J ¼ 7.9, 1.9 Hz, 6 ′ -H), 3.73 (3H, s, 3 ′ -OCH 3 ), 3.57 (1H, m, 5-H), 3.17 (3H, s, 5-OCH 3 ), 2.71 (2H, m, 1-H), 2.62 (1H, dd, J ¼ 15.9, 7.2 Hz, 4a-H), 2.46 (1H, dd, J ¼ 15.9, 5.2 Hz, 4b-H), 0.85 (3H, t, J ¼ 7.0 Hz, 10-H). 13 When H 2 O 2 -induced damaged L02 cells were treated with isolated gingerols, it can be seen from Fig. 4 that the cells in the model group were damaged and the edges shrank, whereas the damaged cells in the four experimental groups all improved in morphology and the cells became rounder and the cell density also increased, but the strength of the antioxidant capacity of the four compounds could not be determined.…”
Section: Purity Activity and Structures Of Fr141231 Fr141241 Fr141261...mentioning
confidence: 96%
“…A Waters QDa ESI mass spectrometer (Waters Instruments Co. USA) was used to conduct ESI-MS analysis. The 600 MHz Bruker Avance was employed to obtain 1 H and 13 C NMR spectra (Bruker Instruments Co. Germany) using DMSO-d 6 as the NMR solvent. UV absorbance values were obtained on a Readmax 1900 microplate reader (Flash, Co. China).…”
Section: Instrumentation and Reagentsmentioning
confidence: 99%
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