Preparation and Antitumor-promoting Activity of Curcumin Encapsulated by 1,3-β-Glucan Isolated from Vietnam Medicinal Mushroom Hericium erinaceum

Abstract

The clinical application of curcumin in cancer treatment is considerably limited due to its serious poor delivery characteristics. In order to increase the hydrophilicity and drug delivery capability, we encapsulated curcumin into 1,3-β-glucan isolated from Vietnam medicinal mushroom Hericium erinaceum. The 1,3-β-glucan-encapsulated curcumin nanoparticles (Cur–Glu) were found to be spherical with an average size of 50 nm, being suitable for drug delivery applications. They were much more soluble in water not only than free curcumin but also than other biodegradable polymer-encapsulated curcumin nanoparticles. An antitumor-promoting assay was carried out, showing the positive effects of Cur–Glu on tumor promotion of Hep-G2 cell line in vitro.

Preparation and Characterization of Starch Nanoparticles for Controlled Release of Curcumin

“…As shown in Figure 3(b), an aqueous solution of curcumin loaded starch nanoparticles showed an absorbance peak at 425.5 nm (Figure 3(ii)) which was observed to be very close to the characteristic absorbance peak of curcumin at 422 nm (Figure 3(i)). The red shift in the UV absorbance peak of curcumin loaded starch nanoparticles was probably attributed to the formation of intermolecular hydrogen bondings between curcumin and starch nanoparticles [31,32].…”

“…International Journal of Polymer Science 7 no. 01 (17)746/2010 (32) and MyBrain15 (MyMaster) Programme for graduate scholarship were gratefully acknowledged.…”

Enhanced Efficacy of Pluronic Copolymer Micelle Encapsulated SCR7 against Cancer Cell Proliferation

“…Such shift in the fluorescence emission is reported for doxorubicin encapsulated with chitosan nano particles and curcumin casein micelles . The blue‐shift in the fluorescence is likely due to the changes in the microenvironment of SCR7 within the hydrophobic core of P123 …”

Evaluation of Albuminated Curcumin as Soluble Drug Form to Control Growth of Cancer Cells <i>in Vitro</i>

“…Extensive work to improve water solubility and enhance therapeutic impact has resulted in encapsulation of Curc into various anionic and cationic micelle systems. Thus drug delivery systems with sodium dodecyl sulfate, cetyl trimethyl ammonium bromide [CTAB] [8], polysaccharides such as 1, 3-β-glucan [9], polyethylene glycol [10] and cyclodextrin inclusions [11] have been reported. In another approach, water soluble Curc complex was synthesized by dissolving and mixing Curc and gelatin in an aqueous acetic acid solution [12].…”