Preparation and application of curcumin loaded with citric acid crosslinked chitosan-gelatin hydrogels

Yang, Jing; Duan, Anbang; Shen, Liping; Liu, Qingye; Wang, Fei; Liu, Yongping

doi:10.1016/j.ijbiomac.2024.130801

Cited by 6 publications

(2 citation statements)

References 55 publications

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“…On the one hand, chitosan (CH) is a natural polymer derived from the deacetylation of chitin, which is present in the exoskeletons of crustaceans. Chitosan and its derivatives have become promising biological materials due to their distinctive molecular structure, excellent biological activities, and their properties such as biocompatibility, biodegradability, cytocompatibility, non-allergenicity, non-toxicity, and mucoadhesiveness, as well as their antitumor, antioxidant, antibacterial, and antifungal activities [22][23][24][25][26][27]. The reactive functional groups found in chitosan play an important role in aiding the synthesis of three-dimensional hydrogel.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, several investigations have exhibited the potential of chitosan and gelatin carriers in drug delivery systems [25]. First, Mahdizadeh et al [33] developed a chitosangelatin carrier, which proved through drug release, release kinetics, and physical and mechanical studies its capability to be used as an insulin nanoparticle carrier.…”

Section: Introductionmentioning

confidence: 99%

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Chitosan–Type-A-Gelatin Hydrogels Used as Potential Platforms in Tissue Engineering for Drug Delivery

Mehdi-Sefiani,

Granados-Carrera,

Romero

et al. 2024

Gels

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Hydrogels are materials made of crosslinked 3D networks of hydrophilic polymer chains that can absorb and retain significant amounts of water due to their hydrophilic structure without being dissolved. In relation to alternative biomaterials, hydrogels offer increased biocompatibility and biodegradability, giving them distinct advantages. Thus, hydrogel platforms are considered to have the potential for the development of biomedical applications. In this study, the main objective was the development of hybrid hydrogels to act as a drug delivery platform. These hydrogels were made from chitosan (CH) and type A gelatin (G), two natural polymers that provide a supportive environment for cellular attachment, viability, and growth, thanks to their unique properties. Particularly, the use of gelatins for drug delivery systems provides biodegradability, biocompatibility, and non-toxicity, which are excellent properties to be used in the human body. However, gelatins have some limitations, such as thermal instability and poor mechanical properties. In order to improve those properties, the aim of this work was the development and characterization of hybrid hydrogels with different ratios of CH–G (100–0, 75–25, 50–50, 25–75, 0–100). Hydrogels were characterized through multiple techniques, including Fourier transform infrared (FTIR) spectroscopy, rheological and microstructural studies, among others. Moreover, a model hydrophilic drug molecule (tetracycline) was incorporated to evaluate the feasibility of this platform to sustain the release of hydrophilic drugs, by being tested in a solution of Phosphate Buffer Solution at a pH of 7.2 and at 37 °C. The results revealed that the synergy between chitosan and type A gelatin improved the mechanical properties as well as the thermal stability of it, revealing that the best ratios of the biopolymers are 50–50 CH–G and 75–25 CH–G. Thereby, these systems were evaluated in a controlled release of tetracycline, showing a controlled drug delivery of 6 h and highlighting their promising application as a platform for controlled drug release.

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