Preparation and Applications of Chiral Polymeric Particles

Abstract

Chiral polymeric particles (CPPs) have been gathering increasing interest as typical functional polymeric particles in recent decades. This article presents a review on the preparation and applications of CPPs. The methods for preparing CPPs are classified into two major groups: The first one is the direct polymerization of monomers and the other is the post-treatment of preformed polymers. CPPs have been explored as a unique type of chiral materials in various fields like asymmetric catalysis, enantioselective release, enantioselective crystallization, and enantioseparation. This review article is expected to accelerate the progress of scientific research dealing with CPPs and their applications in chirality-related fields.

Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction

“…1 Chiral polymeric particles (CPPs) were used as typical functional polymeric particles in recent decades and explored as a special kind of chiral material in asymmetric catalysis, enantioselective release and crystallization, and enantioseparation. 2 Efficient methods to produce and separate chiral compounds are important, in particular for enhancement of pharmaceuticals due to the different pharmacological and toxicological effects of the enantiomers. 3 Previous work in our lab examined enantioselective crystallization of CPPs based on leucine, phenylalanine and alanine in their own supersaturated solution.…”

“…Deng et al, constructed CPPs by polyacetylene with ferrocenyl amino acid derived pendant groups that enabled the particles to be used as catalysts in an asymmetric aldol reaction. 2 In our group, CPPs were synthesized based on N-oleoyl-D/L-proline and used as an organocatalyst to explore the efficiency of catalysis in the asymmetric aldol reaction in an organic solvent and in water. 13 There are a few additional examples of aldol reactions catalyzed by CPPs, [64][65][66] however the efficiency and recovery of the catalyst need to be enhanced.…”