Preparation and assessment of electro-conductive poly(acrylamide-co-acrylic acid) carboxymethyl cellulose/reduced graphene oxide hydrogel with high viscoelasticity

Jafarigol, Elham; Salehi, Mahsa Baghban; Mortaheb, Hamid Reza

doi:10.1016/j.cherd.2020.07.020

Cited by 33 publications

(18 citation statements)

References 34 publications

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“…Hydrogels were allowed to swell in buffer solutions at 30 • C. Figure 4 shows the degree of swelling for the different GO concentrations. When the GO concentration increases in the hydrogel for all the pH values studied, the swelling degree also increases, comparable to previous studies [84]. Noticeably, at pH 3.0, the capacity of the hydrogels to retain water within their structure without deformation is significantly higher compared with pH 7.0 and 10.0.…”

Section: Swelling Degree Of Nanocomposite Hydrogelssupporting

confidence: 89%

“…Finally, after exposure to the small intestine's simulated medium, the hydrogel nanocomposites showed an apparent stabilization in the magnitude of G', which most likely indicates some level of chain rearrangement to achieve the three-dimensional bonding required for a solid-like material [84,[87][88][89][90][91]. Importantly, taken together, these results suggest that during the pass through the GI tract, the material will continue to exhibit a solid-like rheological response, which is critical to assure that a large population of probiotics effectively reaches the site of action.…”

Section: Mechanical Resistance Evaluationmentioning

confidence: 99%

“…This notion is further supported by the high correlation observed between low crosslinking levels (0.0 mg/mL GO) and reduced swelling degrees and pore sizes. In that case, the smaller pore sizes are likely to impose a physical impediment for the water molecules to reach the hydrogel matrix's interior [84,86,87]. Additionally, an important observation is that after 24 h in aqueous solution, none of the GO hydrogels showed structural stability failure or observable changes in their macrostructure.…”

Section: Swelling Degree Of Nanocomposite Hydrogelsmentioning

confidence: 99%

“…This indicates that the nanocomposite hydrogel most likely increases its elasticity and becomes mechanically stronger, favoring applications for the controlled delivery of probiotics and other bioactive molecules. Moreover, this behavior might be exploitable to enable other biological and biomedical applications, including regenerative therapies, cancer therapy, bioadhesives, wastewater treatment, packaging, and coatings [60,67,84,88,91]. (G') modulus for hydrogels after exposure to milli-bioreactor operation for 72 h and human gastrointestinal tract (GIT) simulated media and the comparison with a hydrogel in the absence of each treatment.…”

Section: Rheological Response Of Hydrogels Nanocompositesmentioning

confidence: 99%

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Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

et al. 2021

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Nutraceutical formulations based on probiotic microorganisms have gained significant attention over the past decade due to their beneficial properties on human health. Yeasts offer some advantages over other probiotic organisms, such as immunomodulatory properties, anticancer effects and effective suppression of pathogens. However, one of the main challenges for their oral administration is ensuring that cell viability remains high enough for a sustained therapeutic effect while avoiding possible substrate inhibition issues as they transit through the gastrointestinal (GI) tract. Here, we propose addressing these issues using a probiotic yeast encapsulation strategy, Kluyveromyces lactis, based on gelatin hydrogels doubly cross-linked with graphene oxide (GO) and glutaraldehyde to form highly resistant nanocomposite encapsulates. GO was selected here as a reinforcement agent due to its unique properties, including superior solubility and dispersibility in water and other solvents, high biocompatibility, antimicrobial activity, and response to electrical fields in its reduced form. Finally, GO has been reported to enhance the mechanical properties of several materials, including natural and synthetic polymers and ceramics. The synthesized GO-gelatin nanocomposite hydrogels were characterized in morphological, swelling, mechanical, thermal, and rheological properties and their ability to maintain probiotic cell viability. The obtained nanocomposites exhibited larger pore sizes for successful cell entrapment and proliferation, tunable degradation rates, pH-dependent swelling ratio, and higher mechanical stability and integrity in simulated GI media and during bioreactor operation. These results encourage us to consider the application of the obtained nanocomposites to not only formulate high-performance nutraceuticals but to extend it to tissue engineering, bioadhesives, smart coatings, controlled release systems, and bioproduction of highly added value metabolites.

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Section: Swelling Degree Of Nanocomposite Hydrogelssupporting

confidence: 89%

Section: Mechanical Resistance Evaluationmentioning

confidence: 99%

Section: Swelling Degree Of Nanocomposite Hydrogelsmentioning

confidence: 99%

Section: Rheological Response Of Hydrogels Nanocompositesmentioning

confidence: 99%

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Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

et al. 2021

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“…The conductive hydrogels could be divided into electron-conductive and ion-conductive hydrogels. [9] Electron-conductive hydrogels are constructed by introducing conductive materials (e.g., carbon nanotube, [250] graphene, [251] metals, [252] and conductive polymers [195,253] ) into the polymer networks. Their conductivity mainly results from the movable electrons through tunneling effect and contact effect, and it is weakly dependent on water content.…”

Section: Sensorsmentioning

confidence: 99%

Recent advances in polysaccharide‐based hydrogels for synthesis and applications

Lin

2021

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158

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Hydrogels are three‐dimensional (3D) crosslinked hydrophilic polymer networks that have garnered tremendous interests in many fields, including water treatment, energy storage, and regenerative medicine. However, conventional synthetic polymer hydrogels have poor biocompatibility. In this context, polysaccharides, a class of renewable natural materials with biocompatible and biodegradable properties, have been utilized as building blocks to yield polysaccharide‐based hydrogels through physical and/or chemical crosslinking of polysaccharides via a variety of monomers or ions. These polysaccharide‐derived hydrogels exhibit peculiar physicochemical properties and excellent mechanical properties due to their unique structures and abundant functional groups. This review focuses on recent advances in synthesis and applications of polysaccharide‐based hydrogels by capitalizing on a set of biocompatible and biodegradable polysaccharides (i.e., cellulose, alginate, chitosan, and cyclodextrins [CDs]). First, we introduce the design and synthesis principles for crafting polysaccharide‐based hydrogels. Second, polysaccharide‐based hydrogels that are interconnected via various crosslinking strategies (e.g., physical crosslinking, chemical crosslinking, and double networking) are summarized. In particular, the introduction of noncovalent and/or dynamic covalent interactions imparts polysaccharide‐based hydrogels with a myriad of intriguing performances (e.g., stimuli–response and self‐recovery). Third, the diverse applications of polysaccharide‐based hydrogels in self‐healing, sensory, supercapacitor, battery, drug delivery, wound healing, tissues engineering, and bioimaging fields are discussed. Finally, the perspectives of polysaccharide‐based hydrogels that promote their future design to enable new functions and applications are outlined.

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A conductive, antibacterial, and antifouling hydrogel based on zwitterion

Ding

Wang

et al. 2021

J of Applied Polymer Sci

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This paper proposes a cationic double-network hydrogel, which has good electrical conductivity, antibacterial properties, antiprotein adsorption, and mechanical properties. The cationic polymer formed a conductive path in the hydrogel network, so that the gel had good conductivity. With the increase of carboxybetaine ester, the conductivity gradually increases. As a sensor, hydrogel could respond quickly to strains such as stretching and bending. In addition, the hydrogel showed excellent antibacterial properties against Escherichia coli, the antibacterial rate can reach up to 99%. After hydrolysis, the hydrogel showed stable antiprotein adsorption performance. The tensile strength of the gel could reach 1.05 MPa, and the elongation at break was 474.31%. Therefore, this gel may be used for dressing and electronic skin. And the morphology of the hydrogel was characterized by FT-IR, X-ray diffraction, and SEM.

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Preparation and assessment of electro-conductive poly(acrylamide-co-acrylic acid) carboxymethyl cellulose/reduced graphene oxide hydrogel with high viscoelasticity

Cited by 33 publications

References 34 publications

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

Recent advances in polysaccharide‐based hydrogels for synthesis and applications

A conductive, antibacterial, and antifouling hydrogel based on zwitterion

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