Preparation and Assessment of Physicochemical Possessions, Solubility, and Antimicrobial Properties of Dental Prosthesis Glass Ionomer Cement Containing Curcumin Nanocrystals

Moghaddam, Sahar Choukhachizadeh; Negahdari, Ramin; Sharifi, Simin; Dizaj, Solmaz Maleki; Torab, Ali; Rezaei, Yashar

doi:10.1155/2022/1229185

Cited by 6 publications

(9 citation statements)

References 38 publications

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“…The pattern of rapid release of curcumin in the outer surface of the composites and continuous release in the sixth to 35th days related to the nanoparticles are more internal and may have electrostatic interactions with the gelatin matrix and their release takes time [ 29 ]. Other investigators have also reported similar release patterns for curcumin-loaded dental materials [ 30 , 31 ]. Indeed, to achieve a slow-release behavior, either the sustained-release polymers are needed or a suitable cross-linker is used [ 32 ].…”

Section: Discussionsupporting

confidence: 59%

Gelatin–Curcumin Nanocomposites as a Coating for Implant Healing Abutment: In Vitro Stability Investigation

Dizaj

Torab

Kouhkani

et al. 2023

Clinics and Practice

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Regarding the importance of preventing peri-implantitis in dental implants, the current study aimed to coat a healing abutment with gelatin–curcumin nanocomposites, and the stability of this coating on the healing abutment was evaluated. A cell viability measuring test was used to determine the cytotoxicity of nanocomposites against dental pulp stem cells. To show the pattern of curcumin release from nanocomposites, drug dissolution apparatus two was applied. Then, 16 healing abutments were examined in vitro. Titanium healing abutments were coated with the gelatin–curcumin nanocomposite. The dip coating method was applied for coating and the consistency of coated cases was evaluated at intervals of one, 30, and 60 days after coating inside the simulated body fluid (SBF) solution. A scanning electron microscope (SEM) was used for investigating the microstructure and morphology of coatings, and an energy dispersive X-ray (EDX) was applied for determining the combination of the coating. Moreover, the healings were weighed before and after coating via an accurate digital scale with an accuracy of 0.0001. Finally, the data were analyzed using SPSS software. The prepared nanocomposite was non-cytotoxic against tested cells. The nanocomposite showed a relatively rapid release pattern in the first 10 days for curcumin. The release of curcumin from the nanoparticles continued slowly until the 30th day. The weight changes were statistically significant (p-value < 0.001) during this time. Based on the post hoc test, the weight between two times immediately after coating and 30 days after coating, and also one day after coating and 30 days after coating, was statistically insignificant. The results revealed that the coating of the gelatin–curcumin nanocomposite on the healing was successful and this consistency was kept for at least one month. It is necessary to investigate more evaluations in different fields of physicochemical, mechanical, and antimicrobial aspects for coated healing abutments.

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Section: Discussionsupporting

confidence: 59%

Gelatin–Curcumin Nanocomposites as a Coating for Implant Healing Abutment: In Vitro Stability Investigation

Dizaj

Torab

Kouhkani

et al. 2023

Clinics and Practice

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“…Then, 5 mg of the samples was used. One-milliliter liquid samples were taken from the wells every day and the absorbance was observed by means of a UV spectrophotometer for curcumin at 350 nm [17].…”

Section: Release Studymentioning

confidence: 99%

“…A nanomaterial refers to a material that has at least one dimension in a three-dimensional space or is reduced in composition to a nanoscale (1-100 nm) [14][15][16]. Nano-dentistry is the usage of nanomaterials in the dentistry field [17]. Nanomaterials have broad and promising applications in future dentistry.…”

Section: Introductionmentioning

confidence: 99%

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Nanocurcumin Release from Self-Cured Acrylic Resins; Effects on Antimicrobial Action and Flexural Strength

Soleymanijadidi,

Moradi,

Hamedirad

et al. 2023

Bioengineering

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The placement of orthodontic appliances into the oral area can lead to infection, inflammatory and gingival collapse. Using an antimicrobial and anti-inflammatory material in the matrix of orthodontic appliance may help to reduce these issues. This study aimed to assess the release pattern, the antimicrobial action and the flexural strength of self-cured acrylic resins after adding different weight percentages of curcumin nanoparticles (nanocurcumin). In this in-vitro study, 60 acrylic resin samples were divided into five groups (n = 12) based on the weight percentage of curcumin nanoparticles added to the acrylic powder (0 for control, 0.5, 1, 2.5, and 5%). Then, the dissolution apparatus was used for the release assessment of nanocurcumin form the resins. For antimicrobial action assessment, the disk diffusion method was used and a three-point bending test was performed with a speed of 5 mm/min to determine the flexural strength. Data were analyzed using one-way analysis of variance (ANOVA) and Post-Hoc Tukey tests (with p < 0.05 as significant level). The microscopic images showed the homogeny distribution of nanocuricumin in self-cured acrylic resins in varied concentrations. The release pattern showed a two-step release pattern for all concentrations of nanocurcumin. The one-way ANOVA outcomes indicated that adding curcumin nanoparticles to self-cured resin increased the diameter of the inhibition zones for the groups against Streptococcus mutans (S. mutans) significantly (p < 0.0001). Additionally, as the weight percentage of curcumin nanoparticles increased, the flexural strength decreased (p < 0.0001). However, all strength values were higher than the standard value (50 MPa). No significant difference was detected between the control group and the group with 0.5 percent (p = 0.57). Considering the proper release pattern and the potent antimicrobial activity of curcumin nanoparticles, then the preparing self-cured resins containing curcumin nanoparticles can be beneficial for antimicrobial aims without damaging the flexural strength to use in orthodontic removable applications.

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“…According to the study by Malekzadeh et al, 12 oral nano curcumin was able to display noticeable impacts on decreasing the inflammation and gingival bleeding of patients that suffer from gingivitis and mild periodontitis. Furthermore, Choukhachizadeh et al 15 studied the addition of curcumin nanocrystals to GIC for enhancing the obtained antibacterial properties in comparison to glass ionomer (without curcumin) in the cases of Escherichia coli , Staphylococcus aureus , and Streptococcus mutans . According to their findings, the biggest growth inhibition zone in S. mutans culture was revealed by the addition of 5% micro curcumin to Activa BioActive Base/Liner (ABBL).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effects of Nano Micelles Curcumin and Ibuprofen on Pain Reduction After Initial Arch Wire Placement: A Double-Blind Randomized Clinical Trial Study

Shafaee

Ghiasi

Rahimi

et al. 2023

Journal of Advanced Oral Research

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Aim: To compare the effect of nano micelles curcumin and ibuprofen on pain reduction after primary arch wire placement in orthodontic patients. Materials and Methods: In this double-blind randomized clinical trial study, 60 female patients between the ages of 14 and 30 years who had moderate tooth crowding and were candidates for fixed orthodontic treatment were examined. The subjects were divided into four groups ( n = 15) of nano micelles curcumin (SinaCurcumin), ibuprofen, placebo of SinaCurcumin, and placebo of ibuprofen. Each patient received a questionnaire and a rectangular, flexible cube of silicone to record the severity of their pain under each of the three situations (biting posterior teeth together, fitting anterior teeth together, and without fitting the teeth together) at the designated time points (2 h, 6 h, bedtime, the second, third, and seventh days after archwire placement). The obtained outcomes were statistically verified and analyzed by the employment of SPSS Statistics Version 22. Results: despite the lack of any significant differences among the four groups in terms of pain severity upon biting by the anterior teeth 2 h after the intervention, there was a considerable difference in the cases of 6 h, bedtime, and the second, third, and seventh days subsequent of the placement of archwire. Our data indicated a lower rate of pain severity for SinaCurcumin group than the placebo of SinaCurcumin and ibuprofen groups at 6 h after the archwire placement. However, the pain severity of SinaCurcumin group at bedtime was significantly lower than ibuprofen group, which also resulted in a notably lower rate than the other groups at the second, third, and seventh days after the placement of archwire. Conclusion: These findings support the effectiveness of curcumin in reducing the pain severity of orthodontic patients. Nevertheless, it is a necessity to conduct further confirmation trials on this latter.

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Preparation and Assessment of Physicochemical Possessions, Solubility, and Antimicrobial Properties of Dental Prosthesis Glass Ionomer Cement Containing Curcumin Nanocrystals

Cited by 6 publications

References 38 publications

Gelatin–Curcumin Nanocomposites as a Coating for Implant Healing Abutment: In Vitro Stability Investigation

Gelatin–Curcumin Nanocomposites as a Coating for Implant Healing Abutment: In Vitro Stability Investigation

Nanocurcumin Release from Self-Cured Acrylic Resins; Effects on Antimicrobial Action and Flexural Strength

Comparison of the Effects of Nano Micelles Curcumin and Ibuprofen on Pain Reduction After Initial Arch Wire Placement: A Double-Blind Randomized Clinical Trial Study

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