Preparation and Bio-evaluation of 99mTc-carbonyl Complex of Ursodeoxycholic Acid for Heptobiliary Imaging

Abstract

.The uptake of complex in the liver gave the chance to diagnose it. The results indicate that the labeled compound cleared from the systematic circulation within 2 h after administration and majority of organs showed significant decrease in uptake of it. These results introduce 99m Tc-tricarbonyl UDCA as a novel potential radiopharmaceutical for hepatobiliary imaging.

Facile one-pot strategy for radiopreprationof radioiodinated phenylpiracetam as a new highly selective radiotracer for brainimaging

“…2. The percentage of the labeling yield of [131I]-IodooPHPI was determined as the percent ratio of [131I]-IodooPHPI [81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100].…”

“…[131I]-IodooPHPI stability ex vivo is demonstrated by its absorption by the thyroid gland [111][112][113][114][115][116][117][118][119]. Most organs get the radiotracer, [131I]-IodooPHPI, after 5 minutes postinjection [88][89][90][91][92][93][94][95]. After 5 minutes post-injection, brain uptake was 10.55ID/g%, and after 3 hours, it had declined to 2.11 ID/g%.Low thyroid uptake at all times indicates that the radiotracer [131I]-IodooPHPIcompound is stable in vivo to enzymatic de-iodiantion.The kidney uptake increased up to 17.67 ± 0.99% at 60 min p.i.…”