Preparation and bioavailability of calcium‐chelating peptide complex from tilapia skin hydrolysates

Chen, Jun; Qiu, Xujian; Hao, Gengxin; Zhang, Meng; Weng, Wuyin

doi:10.1002/jsfa.8363

Cited by 39 publications

(32 citation statements)

References 22 publications

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“…Ca deficiency is a worldwide problem owing to insufficient intake and decreasing solubility of Ca due to the precipitation with other constitutes in food (Y. Lin et al., 2020). The amount of Ca absorbed by the body depends on the quantity of soluble Ca in the duodenum and proximal jejunum (Jun Chen et al., 2017). Therefore, controlling the solubility of Ca in the body is important for their bioavailability.…”

Section: Biological Activities Of Fph (In Vitro Studies)mentioning

confidence: 99%

“…SEM and FTIR analyses showed that Ca ion interact with N‐H/C‐N groups in GH. Further in vivo study revealed that Ca‐deficient mice fed with GH‐Ca complex (0.3, 0.75, and 1.5 g/kg BW) and CaCO 3 (0.25 g/kg BW) for 4 weeks showed higher length, weight, Ca content, and hydroxyproline content, and Ca absorption than those fed with CaCO 3 (Jun Chen et al., 2017). Overall, the major AAs responsible for the strongest Ca‐binding properties of peptides are Asp and Glu residues.…”

Section: Biological Activities Of Fph (In Vitro Studies)mentioning

confidence: 99%

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Valorization of fish byproducts: Sources to end‐product applications of bioactive protein hydrolysate

Nirmal

Santivarangkna

Rajput

et al. 2022

Comp Rev Food Sci Food Safe

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Fish processing industries result in an ample number of protein‐rich byproducts, which have been used to produce protein hydrolysate (PH) for human consumption. Chemical, microbial, and enzymatic hydrolysis processes have been implemented for the production of fish PH (FPH) from diverse types of fish processing byproducts. FPH has been reported to possess bioactive active peptides known to exhibit various biological activities such as antioxidant, antimicrobial, angiotensin‐I converting enzyme inhibition, calcium‐binding ability, dipeptidyl peptidase‐IV inhibition, immunomodulation, and antiproliferative activity, which are discussed comprehensively in this review. Appropriate conditions for the hydrolysis process (e.g., type and concentration of enzymes, time, and temperature) play an important role in achieving the desired level of hydrolysis, thus affecting the functional and bioactive properties and stability of FPH. This review provides an in‐depth and comprehensive discussion on the sources, process parameters, purification as well as functional and bioactive properties of FPHs. The most recent research findings on the impact of production parameters, bitterness of peptide, storage, and food processing conditions on functional properties and stability of FPH were also reported. More importantly, the recent studies on biological activities of FPH and in vivo health benefits were discussed with the possible mechanism of action. Furthermore, FPH‐polyphenol conjugate, encapsulation, and digestive stability of FPH were discussed in terms of their potential to be utilized as a nutraceutical ingredient. Last but not the least, various industrial applications of FPH and the fate of FPH in terms of limitations, hurdles, future research directions, and challenges have been addressed.

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Section: Biological Activities Of Fph (In Vitro Studies)mentioning

confidence: 99%

Section: Biological Activities Of Fph (In Vitro Studies)mentioning

confidence: 99%

Valorization of fish byproducts: Sources to end‐product applications of bioactive protein hydrolysate

Nirmal

Santivarangkna

Rajput

et al. 2022

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

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“…Guo and coworkers [94] demonstrated the enhancement of Ca absorption and significant increase in femur bone mineral density and femur Ca content in rats when Ca was supplemented in the form of Ca alginate nanoparticles loaded with collagen peptide chelated Ca suggesting that they could prevent Ca deficiency. In addition, Chen et al [95] demonstrated that a calciumchelating peptide complex prepared from tilapia skins could promote bone formation and an increase in bone collagen in mice via a better bioavailability of Ca. Zinc in the form of methionine hydroxy analog chelate zinc has been found to be more stable than other organic Zn forms and has higher bioavailability in broilers [96] and laying hens from 39 to 52 weeks of age [97].…”

Section: Bioavailability Of Micronutrients (Vitamins and Minerals)mentioning

confidence: 99%

Importance of micronutrients in bone health of monogastric animals and techniques to improve the bioavailability of micronutrient supplements — A review

Upadhaya¹,

Kim²

2020

Asian-Australas J Anim Sci

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Vitamins and minerals categorized as micronutrients are the essential components of animal feed for maintaining health and improving immunity. Micronutrients are important bioactive molecules and cofactors of enzymes as well. Besides being cofactors for enzymes, some vitamins such as the fat-soluble vitamins, vitamin A and D have been shown to exhibit hormone-like functions. Although they are required in small amount, they play an influential role in the proper functioning of a number of enzymes which are involved in many metabolic, biochemical and physiological processes that contribute to growth, production and health. Micronutrients can potentially have a positive impact on bone health, preventing bone loss and fractures, decreasing bone resorption and increasing bone formation. Thus, micronutrients must be provided to livestock in optimal concentrations and according to requirements that change during the rapid growth and development of the animal and the production cycle. The supply of nutrients to the animal body not only depends on the amount of the nutrient in a food, but also on its bioavailability. The bioavailability of these micronutrients is affected by several factors. Therefore, several technologies such as nanoparticle, encapsulation, and chelation have been developed to improve the bioavailability of micronutrients associated with bone health. The intention of this review is to provide an updated overview of the importance of micronutrients on bone health and methods applied to improve their bioavailability.

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“…Furthermore, it has been widely used as a biomaterial (e.g., as a scaffold for cell and tissue regeneration-related proteins, wound dressing, or dietary supplement) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] because of its biocompatibility. In particular, collagen peptides, which are enzymatically hydrolyzed from gelatin, are often administered orally because they are easily digestible 18) , and have been reported to have a positive effect on skin, cartilage and bone [19][20][21][22][23][24][25][26][27][28][29][30][31][32] . Tanaka et al reported that the oral administration of fish scale collagen peptides to hairless mice inhibited Ultraviolet Light B (UV-B)-induced skin dehydration, reduced epidermal hyperplasia, and decreased soluble type I collagen 25) .…”

Section: Introductionmentioning

confidence: 99%

Functional roles of fish collagen peptides on bone regeneration

et al. 2021

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Fish collagen peptides (FCP) derived from the skin, bones and scales are commercially used as a functional food or dietary supplement for hypertension and diabetes. However, there is limited evidence on the effects of FCP on the osteoblast function in contrast to evidence of the effects on wound healing, diabetes and bone regeneration, which have been obtained from animal studies. In this narrative review, we expound on the availability of FCP by basic research using osteoblasts. Low-concentration FCP upregulates the expression of osteoblast proliferation, differentiation and collagen modifying enzyme-related genes. Furthermore, it could accelerate matrix mineralization. FCP may have potential utility as a biomaterial to improve collagen quality and promote mineralization through the mitogen-activated protein kinase and Smad cascades. However, there are few clinical studies on bone regeneration in human subjects. It is desirable to be applied clinically through clinical study as soon as possible, based on the results from basic research.

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Preparation and bioavailability of calcium‐chelating peptide complex from tilapia skin hydrolysates

Abstract: It is concluded that the prepared CPC could promote bone formation via better bioavailability of Ca and an increase in bone collagen. © 2017 Society of Chemical Industry.

Cited by 39 publications

References 22 publications

Valorization of fish byproducts: Sources to end‐product applications of bioactive protein hydrolysate

Valorization of fish byproducts: Sources to end‐product applications of bioactive protein hydrolysate

Importance of micronutrients in bone health of monogastric animals and techniques to improve the bioavailability of micronutrient supplements — A review

Functional roles of fish collagen peptides on bone regeneration

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