Preparation and Biological Evaluation of Novel Pyrimidines from Novel Chalcones

Jyothi, M.; Venkatesh, P.

doi:10.13005/ojc/280346

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…Jyothi M V et al 37 synthesized pyrazolines (2j) and studied for their anti-inflammatory activity. Compounds possess some degree of antiinflammatory activity and were free from toxicity Khalil et al 38 inferred the compound (2k) of 3, 5-Diaryl-2-Pyrazoline Derivatives as most potent, which has shown higher percentage of inhibition of edema than the standard drug indomethacin.…”

Section: P Vaidya Et Almentioning

confidence: 99%

Untitled

2015

IJPSR

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Section: P Vaidya Et Almentioning

confidence: 99%

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2015

IJPSR

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“…These methods provided invaluable insights into the molecular compositions and arrangements of the Oxazines and Thiazines. Furthermore, the study encompassed antimicrobial screening assays [9][10] to evaluate the potential bioactivity of these compounds. The screening assays were conducted with the use of DMSO as the solvent, and the results were meticulously recorded.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Evaluation of Antimicrobial Properties of Novel Oxazine and Thiazine Compounds Derived from Chalcones

Prajapati,

S. Shah,

Malaviya

2023

Orient. J. Chem

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In this ongoing research, our objective is to synthesize Oxazines and Thiazines by employing Chalcones, providing an uncomplicated approach for generating diverse heterocyclic derivatives. These substances show a wide spectrum of biological impact, i.e. analgesic, anti-phlogistic, and anti-convulsant properties. To characterize these newly synthesized compounds, we conducted comprehensive analyses employing techniques such as infrared spectroscopy (IR), proton nuclear magnetic resonance (1H NMR), carbon-13 nuclear magnetic resonance (13C NMR), and mass spectrometry. Additionally, we evaluated the antimicrobial potential of these compounds.

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“…[98,99] Besides, various conditions have been employed during the synthesis of pyrimidine (i.e., microwave, [100][101][102] ultrasonic-MW, [103] ultrasonic irradiations. [104][105][106] conventional way via reflux, [107][108][109] phase transfer, [110] stirring. [111] in basic/acidic media (i.e., conc.…”

Section: Introductionmentioning

confidence: 99%

One‐potandtwo‐potmethods for chalcone derived pyrimidines synthesis and applications

Farooq

Ngaini

2021

Journal of Heterocyclic Chem

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Chalcone-derived pyrimidine is a well-known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio-isosteres. Pyrimidine derivatives are effective in both the electronic industry and drug industries. This review highlights the synthesis of pyrimidines, namely mono-pyrimidine, bis-pyrimidine, fused pyrimidine, symmetric, and asymmetric pyrimidine via one-pot and two-pot methods. The one-pot method is the direct reaction of amino derivatives with aldehydes and acetophenones, whereas the two-pot method is frequently reported for the synthesis of chalcone before the cyclization to a pyrimidine. This review is important in organic synthesis, particularly in the heterocyclic field, regarding pyrimidines and their significance in therapeutic and electronic industries.

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Preparation and Biological Evaluation of Novel Pyrimidines from Novel Chalcones

Cited by 6 publications

References 2 publications

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Synthesis, Characterization and Evaluation of Antimicrobial Properties of Novel Oxazine and Thiazine Compounds Derived from Chalcones

One‐potandtwo‐potmethods for chalcone derived pyrimidines synthesis and applications

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