Preparation and biomedical application of injectable hydrogels

Abstract

Injectable hydrogels are increasingly popular among researchers because of their in situ formability, in situ drug delivery, high targeting, and the ability to allow uniform incorporation of therapeutic molecules and/or...

Contact‐Free Remote Manipulation of Hydrogel Properties Using Light‐Triggerable Nanoparticles: A Materials Science Perspective for Biomedical Applications

“…Lastly, injectable light‐triggered nanocomposite hydrogels are formed mainly by physical crosslinking. [ 60 ] The weaker physical bonds, in this case, allow for the hydrogel to behave as a fluid upon the application of shear stress. However, upon the release of shear stress, such hydrogels return to a more solid‐like structure.…”

Therapeutic Treatments for Osteoporosis—Which Combination of Pills Is the Best among the Bad?

“…Here, the scaffold acts as a substitute for a separate drug delivery material, as discussed in the next section. Proven biocompatibility, option to tailor chemical composition and 3D structure of bilk polymers and surfaces to reach high porosity and tunable pore sizes Low mechanical strength, premature degradation [238,246] Poly(vinyl alcohol) (PVA) modified with gelatin [234] Polyesters such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers (PLA/PGA) [231,247,248] Poly(ethylene glycol diacrylate) (PEGDA) combined with laponite nanoclay (a mineral consisting of magnesium (Mg), lithium (Li), and silicon(Si)) [249,250] Polyetherketoneketone scaffold with a functionalized Sr-doped nano-HA coating Biomimetically hierarchical structures; due to local release of Sr, enhancement of the intrinsic mechanical strength at microlevel resulting in improved bonding strength (of scaffold and host bone)…”

Effect of H-bonding on network junction and macroscopic elastomer properties in photocured polyacrylate films

“…3), demonstrates that there is a single glass transition temperature, T g , for all networks, indicating good mesoscopic mixing (on a length scale of smaller than several tens of nanometers) between PEGDA and the monoacrylate in all cases. The T g values of the networks were determined from the temperature at the maximum of tan d. 4 The storage moduli (E 0 ) of the two series show similar decreases with increasing monoacrylate content. According to classical rubber elasticity theory, the mean molar mass of network chains between chemical crosslinks and trapped chain entanglements, M c+e , can be calculated using rubber elasticity theory (see ESI † for details).…”

“…Among the available methods for producing polyacrylates, photoinitiated curing is the most popular approach implemented in industrial manufacture due to its ease of application and fast production. [1][2][3][4] Modification of photo-cured crosslinked networks can be easily achieved by copolymerizing functionalized (e.g. hydrogen bonding capable) mono-vinyl monomers with divinyl crosslinkers, enabling tailoring of their macroscopic properties.…”