Preparation and Biomedical Applications of Core–Shell Silica/Magnetic Nanoparticle Composites

Li, Chuanyan; Ma, Chao; Wang, Fang; Xil, Zhijiang; Wang, Zhifei; Deng, Yan; Hel, Nongyue

doi:10.1166/jnn.2012.6428

Cited by 94 publications

(54 citation statements)

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“…The synthesised nanocomposites possess appealing and unique properties that render them attractive for application in healthcare, environmental remediation, and energy storage and conversion. [1][2][3][4][5][6][7] Building tailored layered double hydroxide (LDH)-based nanocomposites is an emerging area in the field of constructing 3-dimensional (3D) hierarchical nanoarchitectures with multiple functionalities. Inorganic LDH compounds, also known as hydrotalcite-like materials or anionic clays, can be found naturally as minerals and can also be readily …”

Section: Introductionmentioning

confidence: 99%

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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a Layered double hydroxide (LDH)-based nanocomposites, constructed by interacting LDH nanoparticles with other nanomaterials (e.g. silica nanoparticles and magnetic nanoparticles) or polymeric molecules (e.g. proteins), are an emerging yet active area in healthcare, environmental remediation, energy conversion and storage.Combining advantages of each component in the structure and functions, hierarchical LDH-based nanocomposites have shown great potential in biomedicine, water purification, and energy storage and conversion.This feature article summarises the recent advances in LDH-based nanocomposites, focusing on their synthesis, structure, and application in drug delivery, bio-imaging, water purification, supercapacitors, and catalysis.

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Section: Introductionmentioning

confidence: 99%

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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“…However, it is hard to produce magnetic composite particles with submicron size with this method. 19 The second method is based on the Stöber process, in which silica is formed by the hydrolysis and condensation of TEOS in an ethanol-ammonia mixture. 20,21 The Stöber process is the prevailing choice for coating Fe 3 O 4 -MNP with silica, and has been proved to be an easy and efficient way to acquire silica-coated magnetic spheres.…”

Section: Introductionmentioning

confidence: 99%

“…20,21 The Stöber process is the prevailing choice for coating Fe 3 O 4 -MNP with silica, and has been proved to be an easy and efficient way to acquire silica-coated magnetic spheres. 19 Myocardial infarction and venous thromboembolism are the major causes of cardiovascular mortality, which results in over 1 million deaths each year in the US. 22,23 Thrombosis, beginning with endothelial injury followed by platelet activation, is responsible for most of the pathophysiology of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle

Chen¹,

Yang²,

Ma³

et al. 2012

IJN

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Background and methods: Silica-coated magnetic nanoparticle (SiO 2 -MNP) prepared by the sol-gel method was studied as a nanocarrier for targeted delivery of tissue plasminogen activator (tPA). The nanocarrier consists of a superparamagnetic iron oxide core and an SiO 2 shell and is characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, superconducting quantum interference device, and thermogravimetric analysis. An amine-terminated surface silanizing agent (3-aminopropyltrimethoxysilane) was used to functionalize the SiO 2 surface, which provides abundant -NH 2 functional groups for conjugating with tPA. Results: The optimum drug loading is reached when 0.5 mg/mL tPA is conjugated with 5 mg SiO 2 -MNP where 94% tPA is attached to the carrier with 86% retention of amidolytic activity and full retention of fibrinolytic activity. In vitro biocompatibility determined by lactate dehydrogenase release and cell proliferation indicated that SiO 2 -MNP does not elicit cytotoxicity. Hematological analysis of blood samples withdrawn from mice after venous administration indicates that tPA-conjugated SiO 2 -MNP (SiO 2 -MNP-tPA) did not alter blood component concentrations. After conjugating to SiO 2 -MNP, tPA showed enhanced storage stability in buffer and operation stability in whole blood up to 9.5 and 2.8-fold, respectively. Effective thrombolysis with SiO 2 -MNP-tPA under magnetic guidance is demonstrated in an ex vivo thrombolysis model where 34% and 40% reductions in blood clot lysis time were observed compared with runs without magnetic targeting and with free tPA, respectively, using the same drug dosage. Enhanced penetration of SiO 2 -MNP-tPA into blood clots under magnetic guidance was confirmed from microcomputed tomography analysis. Conclusion: Biocompatible SiO 2 -MNP developed in this study will be useful as a magnetic targeting drug carrier to improve clinical thrombolytic therapy.

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“…Despite being able to produce multilayer films, the technique itself is time consuming, requires expensive equipment to perform and is limited by the type of molecules that can be used. The advent of LBL assembly enabled many of these limitations to be overcome, and as a result it has become a popular approach to multilayer assembly [5][6][7][8][9]. Using this method, polyelectrolyte multilayers (PEMs) are fabricated by sequential, alternating adsorption of negatively and positively charged polymers (polyelectrolytes, PE) onto a charged substrate.…”

Section: Introductionmentioning

confidence: 99%

Development of a Biocompatible Layer-by-Layer Film System Using Aptamer Technology for Smart Material Applications

Foster

DeRosa

2014

Polymers

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Aptamers are short, single-stranded nucleic acids that fold into well-defined three dimensional (3D) structures that allow for binding to a target molecule with affinities and specificities that can rival or in some cases exceed those of antibodies. The compatibility of aptamers with nanostructures such as thin films, in combination with their affinity, selectivity, and conformational changes upon target interaction, could set the foundation for the development of novel smart materials. In this study, the development of a biocompatible aptamer-polyelectrolyte film system was investigated using a layer-by-layer approach. Using fluorescence microscopy, we demonstrated the ability of the sulforhodamine B aptamer to bind its cognate target while sequestered in a chitosan-hyaluronan film matrix. Studies using Ultraviolet-visible (UV-Vis) spectrophotometry also suggest that deposition conditions such as rinsing time and volume play a strong role in the internal film interactions and growth mechanisms of chitosan-hyaluronan films. The continued study and development of aptamer-functionalized thin films provides endless new opportunities for novel smart materials and has the potential to revolutionize the field of controlled release.

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Preparation and Biomedical Applications of Core–Shell Silica/Magnetic Nanoparticle Composites

Cited by 94 publications

References 0 publications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle

Development of a Biocompatible Layer-by-Layer Film System Using Aptamer Technology for Smart Material Applications

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