We Successfully synthesized novel silica-supported Ni (II)-PLP-ONNO Schiff base/SBA-15 complex, as a mesoporous catalyst, whose characterization was determined using X-ray diffraction analysis, Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, inductively coupled plasma-atomic emission spectroscopy, nitrogen adsorption desorption isotherms (BET-EDX) and (BET-BJH), and thermo-gravimetric analysis. As a fabricated catalyst was employed, for facile and efficient, one-pot production of various benzothiazole heterocycles by cyclocondensation reactions of 2-amionthiophenol and benzaldehyde compounds under green and mild conditions with good to excellent yields. The prepared nano catalyst can offer high stability, excellent activity, easy separation, and reusability, as well environmentally friendly, compared to its homogeneous compounds.