Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Kovar, David R.; Malá, Aneta; Mlčochová, Jitka; Kalina, Michal; Fohlerová, Zdenka; Hlaváček, Antonín; Skládal, Petr; Starčuk, Zenon; Jiřík, Radovan; Slabý, Ondřej; Hubálek, Jaromír

doi:10.1155/2017/7859289

Cited by 30 publications

(10 citation statements)

References 37 publications

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“…Dynamic Light Scattering (DLS) was exploited to investigate the colloidal stability of water dispersion of G-M48 through the measurement of the zeta potential. The obtained zeta potential value of -23.2 ± 10.7 mV, reported in Figure S1 , confirms good colloidal stability 32 .…”

Section: Resultssupporting

confidence: 63%

Nanoparticles exhibiting self-regulating temperature as innovative agents for Magnetic Fluid Hyperthermia

Gerosa¹,

Grande²,

Busato³

et al. 2021

Nanotheranostics

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During the last few years, for therapeutic purposes in oncology, considerable attention has been focused on a method called magnetic fluid hyperthermia (MFH) based on local heating of tumor cells. In this paper, an innovative, promising nanomaterial, M48 composed of iron oxide-based phases has been tested. M48 shows self-regulating temperature due to the observable second order magnetic phase transition from ferromagnetic to paramagnetic state. A specific hydrophilic coating based on both citrate ions and glucose molecules allows high biocompatibility of the nanomaterial in biological matrices and its use in vivo . MFH mediator efficiency is demonstrated in vitro and in vivo in breast cancer cells and tumors, confirming excellent features for biomedical application. The temperature increase, up to the Curie temperature, gives rise to a phase transition from ferromagnetic to paramagnetic state, promoting a shortage of the r 2 transversal relaxivity that allows a switch in the contrast in Magnetic Resonance Imaging (MRI). Combining this feature with a competitive high transversal (spin-spin) relaxivity, M48 paves the way for a new class of temperature sensitive T 2 relaxing contrast agents. Overall, the results obtained in this study prepare for a more affordable and tunable heating mechanism preventing the damages of the surrounding healthy tissues and, at the same time, allowing monitoring of the temperature reached.

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Section: Resultssupporting

confidence: 63%

Nanoparticles exhibiting self-regulating temperature as innovative agents for Magnetic Fluid Hyperthermia

Gerosa¹,

Grande²,

Busato³

et al. 2021

Nanotheranostics

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show abstract

“…Figure 2(f) showed the particle size distribution, percentage of intensity versus sizes of IONPs from which we obtained the average particle size of IONPs found to be ~70d nm which was hydro dynamic diameter of the nanoparticles. The identical result was conformed in the XRD pattern [75]. Thus there was a good correlation in similarity of size of nanoparticles ranging from 40 nm to 70 nm experimentally obtained from the XRD SEM, DLS techniques.…”

Section: Dynamic Light Scattering Analysissupporting

confidence: 82%

Green Synthesis of Iron Oxide Nanoparticles to Explore Cytotoxic Behaviour and to Diminish Environmental Pollution by a Novel Contrivance

2021

JCBSC

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To overcome the side effects of conventional chemotherapy, the study of effective anticancer application of magnetic iron oxide nanoparticles is now-a-days a great area of research which is increasing day by day. In our present study, Iron oxide nanoparticles (IONPs) have been synthesised by reducing ferrous sulphate using Punica granatum peel extracts. Punica granatum peel extract has a rich source of flavonoids and phenolic compounds with high antioxidant and these molecules can be used as excellent reducing agents. The nanopowders have been calcined at 700 0 C for 4 hours. Physicochemical, optical, photocatalytic, cytotoxicity activities (both in normal and carcinoma cell) and morphological assessment of carcinoma cells are characterised using analytical techniques. XRD data, DLS, FTIR spectra and Scanning electron microscope analysis have confirmed the formation of IONPs having spherical shape with trigonal (rhombohedral axes) phase structure, smaller size (average size from XRD 43-47 nm) and large surface area. From UV-Vis absorption spectra and Tauc plot the optical band gap has been obtained 3.5 e.V. IONPs show good photo-Fenton in Methylene blue (MB) dye degradation within 15 minutes with ~91% and 40 minutes with 99% for under optimum condition. The cytotoxicity in Human hepatic cell line (WRL-68) and human hepatocellular carcinoma (HUH-7) cell lines have also been observed using MTT assay and verified Green Synthesis … Shatarupa Basak et al.

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“…The synthesis parameters (adjusting pH, ionic strength, temperature), including the time and rate of adding the base, were carefully monitored and optimized. In the recent study on preparation and characterization of highly stable iron oxide nanoparticles for magnetic resonance imaging [ 33 ], it was shown that the slow formation of nanoparticle seeds was followed by a faster formation of cores and a slow formation of stabilized shells. According to Massart studies on preparation of aqueous magnetic liquids in alkaline and acidic media [ 34 ], the increase of pH from 4 to 11 of the FeCl 2 /FeCl 3 precursor solution by addition of the NaOH induces the co-precipitation of iron oxide particles.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

et al. 2021

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In the present study, we report the synthesis of a dextran coated iron oxide nanoparticles (DIO-NPs) thin layer on glass substrate by an adapted method. The surface morphology of the obtained samples was analyzed by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), optical, and metallographic microscopies. In addition, the distribution of the chemical elements into the DIO-NPs thin layer was analyzed by Glow Discharge Optical Emission Spectrometry (GDOES). Furthermore, the chemical bonds formed between the dextran and iron oxide nanoparticles was investigated by Fourier Transform Infrared Spectroscopy (FTIR). Additionally, the HepG2 viability incubated with the DIO-NPs layers was evaluated at different time intervals using MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The goal of this study was to obtain a DIO-NPs thin layer which could be used as a coating for medical devices such as microfluidic channel, microchips, and catheter. The results of the surface morphology investigations conducted on DIO-NPs thin layer suggests the presence of a continuous and homogeneous layer. In addition, the GDOES results indicate the presence of C, H, Fe, and O signal intensities characteristic to the DIO-NPs layers. The presence in the IR spectra of the Fe-CO metal carbonyl vibration bonds prove that the linkage between iron oxide nanoparticles and dextran take place through carbon–oxygen bonds. The cytotoxicity assays highlighted that HepG2 cells morphology did not show any noticeable modifications after being incubated with DIO-NPs layers. In addition, the MTT assay suggested that the DIO-NPs layers did not present any toxic effects towards HEpG2 cells.

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Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Cited by 30 publications

References 37 publications

Nanoparticles exhibiting self-regulating temperature as innovative agents for Magnetic Fluid Hyperthermia

Nanoparticles exhibiting self-regulating temperature as innovative agents for Magnetic Fluid Hyperthermia

Green Synthesis of Iron Oxide Nanoparticles to Explore Cytotoxic Behaviour and to Diminish Environmental Pollution by a Novel Contrivance

Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

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