Preparation and characteristics of monoclonal IKO-GM-1 antibodies

Kryzhanov, M. A.; Baryshnikov, A. Yu.; Blokhina, N. G.; Frenkel, M. A.; Тупицын, Н. Н.; Trubcheninova, L P; Соколов, А. В.; Kharlamova, L. A.; Заботина, Т. Н.; Saveleva, Ekaterina; Кадагидзе, З. Г.

doi:10.1007/bf00839271

Bull Exp Biol Med

1985

DOI: 10.1007/bf00839271

|View full text |Cite

Preparation and characteristics of monoclonal IKO-GM-1 antibodies

M. A. Kryzhanov¹,

A. Yu. Baryshnikov²,

N. G. Blokhina³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1986

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

Monoclonal antibodies in studying immunological phenotypes of neoplastic diseases

Кадагидзе

Baryshnikov

1986

Seminars in Surgical Oncology

View full text Add to dashboard Cite

Six hybridoma clones were obtained secreting monoclonal antibodies (Mab) against differentiating antigens of human hemopoietic cells. ICO-1 Mab detect Ia-like (Dr) antigens. Mab react with B-lymphocytes and monocytes without detecting antigens on granulocytes and T-cells. Antigen expression was enhanced following cell activation in a blast cell transformation test and mixed lymphocyte culture (MLC). ICO-1 Mab blocked MLC. The molecular weights of the antigen were 29 and 34 kilodaltons. Comparative studies of ICO-1 Mab with other Mab against Ia-like antigens revealed their identical reactivity. ICO-11 Mab detect the antigen on 4% of blood lymphocytes, 75% thymocytes, monoblasts, and CFU-GM. These Mab block NK-cell activity of blood mononuclear cells. ICO-GM-1 Mab detect the antigen on myelomonocytic cells and their precursors, but not CFU-GM. These Mab block binding of the C3Bi complement component to CR3 receptor and NK-cell activity. ICO-G2 Mab detect the antigen expressed at final stages of granulocyte differentiation. ICO-10 Mab detect the antigen on early thymocytes and ICO-02 on undifferentiated blast cells. Mab were shown to be applicable for human leukemia and lymphoma immune diagnosis.

show abstract

Monoclonal antibodies in studying immunological phenotypes of neoplastic diseases

Кадагидзе

Baryshnikov

1986

Seminars in Surgical Oncology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Preparation and characteristics of monoclonal IKO-GM-1 antibodies

Cited by 1 publication

References 1 publication

Monoclonal antibodies in studying immunological phenotypes of neoplastic diseases

Monoclonal antibodies in studying immunological phenotypes of neoplastic diseases

Contact Info

Product

Resources

About