Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway

Zha, Zhengqi; Liu, Yaoyao; Miao, Yinghua; Liao, Shiying; Wang, Suyan; Tang, Huiling; Yin, Hongping

doi:10.1016/j.ijbiomac.2021.12.098

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…One interesting achievement is the mutational expression of one 6- O -sulfotransferase (6-OST), 6-OST Mt-4, to induce specific sulfation of the non-reducing terminal glucosamine residues [ 104 ]. In addition, N -deacetylation by chemical reaction, and enzymatic modification on human 3- O -sulfotransferase-1 (3-OST-1), successively led to the single-site sulfated heparosan, 2-deacetyl-3- O -sulfo-heparosan, which exhibits certain anti-tumor activity in vitro [ 105 ]. Although the progress in chemoenzymatic synthesis are encouraging, there is still a long way to achieve industrial-scale production.…”

Section: Synthesis Of Heparin Mimeticsmentioning

confidence: 99%

Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing

Jiang

Zhang²,

Lu³

et al. 2023

Synthetic and Systems Biotechnology

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Section: Synthesis Of Heparin Mimeticsmentioning

confidence: 99%

Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing

Jiang

Zhang²,

Lu³

et al. 2023

Synthetic and Systems Biotechnology

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Preparation, structural characterization, biological activity, and nutritional applications of oligosaccharides

Chen,

Sui,

Wang

et al. 2024

Food Chemistry: X

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Multifaceted Heparin: Diverse Applications beyond Anticoagulant Therapy

Sultana,

Kamihira

2024

Pharmaceuticals

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Heparin, a naturally occurring polysaccharide, has fascinated researchers and clinicians for nearly a century due to its versatile biological properties and has been used for various therapeutic purposes. Discovered in the early 20th century, heparin has been a key therapeutic anticoagulant ever since, and its use is now implemented as a life-saving pharmacological intervention in the management of thrombotic disorders and beyond. In addition to its known anticoagulant properties, heparin has been found to exhibit anti-inflammatory, antiviral, and anti-tumorigenic activities, which may lead to its widespread use in the future as an essential drug against infectious diseases such as COVID-19 and in various medical treatments. Furthermore, recent advancements in nanotechnology, including nano-drug delivery systems and nanomaterials, have significantly enhanced the intrinsic biofunctionalities of heparin. These breakthroughs have paved the way for innovative applications in medicine and therapy, expanding the potential of heparin research. Therefore, this review aims to provide a creation profile of heparin, space for its utilities in therapeutic complications, and future characteristics such as bioengineering and nanotechnology. It also discusses the challenges and opportunities in realizing the full potential of heparin to improve patient outcomes and elevate therapeutic interventions.

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Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway

Cited by 3 publications

References 45 publications

Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing

Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing

Preparation, structural characterization, biological activity, and nutritional applications of oligosaccharides

Multifaceted Heparin: Diverse Applications beyond Anticoagulant Therapy

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