Preparation and characterization of 2‐methacryloyloxyethyl phosphorylcholine polymer nanofibers prepared via electrospinning for biomedical materials

Abstract

Electrospun nanofibers of poly (2‐methacryloyloxyethyl phosphorylcholine) (MPC) possessing excellent hemocompatibility were successfully fabricated first. These nanofibers were investigated as drug‐delivery vehicles for suppressing the acute thrombogenicity of vascular grafts to lower the risk of coronary artery disease by improving the graft patency rate; the graft patency rate is the percentage of patients who do not have any blockage in a graft after a stent‐graft treatment. We varied the MPC concentrations in ethanol from 1 to 10 wt % to fabricate electrospun MPC fibers. Scanning electron microscopy images revealed that when the MPC concentration was lower than 5 wt %, beads instead of fibers were formed. When the MPC concentration was increased (>5 wt %), uniform fibers were produced with average fiber diameters of about 160 nm (5 wt %), 640 nm (7.5 wt %), and 1270 nm (10 wt %). In vitro drug‐release tests showed that a higher amount of drugs was diffused from MPC fibers with small diameters; this indicated a faster drug‐release rate for the thinner MPC fibers. Diameter‐controlled MPC fibers could be used as a new vascular graft materials. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40606.

Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release

“…It was found that the number of observed platelets increased, as the diameter increased regarding the nanofiber specimens. Our previous study revealed that the MPC fibers of large diameter had higher Ra (the arithmetic average of the roughness profile) than those of small diameter [7], indicating a close relationship between the surface roughness and the antithrombogenicity of MPC fibers.…”

“…MPC was mixed in ethanol to make 5 wt%, 7.5 wt%, and 10 wt% MPC solutions that were electrospun under the same experimental conditions studied before [7]. MPC nanofibers with the diameter of 164 nm, 637 nm, and 1270 nm were eventually synthesized for the platelet adhesion and activation tests.…”

“…Our research group has been investigating the fabrication of electrospun nanofibers of biocompatible poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) [7], one of the most frequently studied phospholipid biopolymers [8,9]. For the promotion of endothelialization, MPC nanofibers containing the drug for the endothelialization could work as a useful drug-delivery system.…”

“…For the promotion of endothelialization, MPC nanofibers containing the drug for the endothelialization could work as a useful drug-delivery system. We studied the controlled drug-release profile of electrospun MPC nanofibers by changing their diameters to control the surface area [7], finding that the controlled drug release from nanofibers could effectively induce cell proliferation [10].…”

Effect of polymer concentration on electrospinning of hydroxypropyl-β-cyclodextrins/PEO nanofibres

“…Several studies (Chowdhury & Stylios, 2010;Deitzel et al, 2001;Maeda, Hagiwara, Yoshida, Hasebe, & Hotta, 2014;Theron, Zussman, & Yarin, 2004) have shown the effects of polymer concentration on the diameter and the morphology of the electrospun nanofibres. Higher polymer concentrations are more likely to produce uniform fibres with higher diameters.…”