Preparation and characterization of [6]-gingerol/β-cyclodextrin inclusion complexes

Development of Cyclodextrin-Functionalized Transethoniosomes of 6-Gingerol: Statistical Optimization, In Vitro Characterization and Assessment of Cytotoxic and Anti-Inflammatory Effects

“…These results are in agreement with da Silva et al [20] who reported the disappearance of the characteristic peak of 6-G molecule after the formation of the inclusion complex with βCD. Moreover, Davaatseren et al [31] found that after the development of the inclusion complex of cinnamaldehyde with βCD, the endothermic peak of cinnamaldehyde disappeared with the formation of a new peak with a different thermal transition.…”

“…Other researchers, such as Pais et al [21] and Singh et al [25], studied the DSC profile of 6-G and found that it showed an endothermic peak at 29.5 • C and 31.23 • C, respectively, due to its melting point. Moreover, da Silva et al [20] and Wei et al [26] reported that 6-G exhibited an endothermic peak at 224.6 • C and 242.74 • C, respectively. In addition, HPβCD had a broad absorption peak at 91.9 • C (∆H = 290.51 J/g), which was correlated with the dehydration process in the HPβCD cavity and another peak at 262.2 (∆H = 155.25 J/g) that corresponded with the decomposition of HPβCD.…”

“…Therefore, the change of DSC thermogram could be used to investigate the formation of the inclusion complex. The DSC curve of 6-G exhibited two characteristic endothermic peaks at about 34.8 • C (∆H = 216.33 J/g) and 224.2 • C (∆H = 175.88 J/g) [20,21,25]. Other researchers, such as Pais et al [21] and Singh et al [25], studied the DSC profile of 6-G and found that it showed an endothermic peak at 29.5 • C and 31.23 • C, respectively, due to its melting point.…”

“…CDs have a special geometric arrangement with a hydrophobic core and hydrophilic surface that permits the inclusion of hydrophobic drugs. Some researchers, such as da Silva et al [20], showed that complexation with βCD has improved the solubility and cytotoxicity of 6-G. In another study, Pais et al [21] prepared an effective inclusion complex of gingerol-enriched extract with γCD and reported that CDs are suitable carriers for gingerols.…”

Enhanced oral bioavailability of koumine by complexation with hydroxypropyl-β-cyclodextrin: preparation, optimization, ex vivo and in vivo characterization

“…Additionally, It has been reported that when ΔH3 > ΔH5, part of the drug is included in the cavity, and when ΔH3 ≤ΔH5, total inclusion takes place (Silva et al. 2021 ). In our study, KME/HP-β-CD presented ΔH3 > ΔH5, indicating that part of KME was contained in the cavity of the CD molecule, resulting in less stable inclusion complexes.…”