Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Yue, Yunqing; Xu, Peihu; Lei, Zhixin; Li, Kebi; Wen, Jing; Wang, Sining; Cheng, Wanting; Lin, Sihui; Huang, Zhijun; Xu, Haixing

doi:10.1039/d2ra00311b

Cited by 6 publications

(4 citation statements)

References 68 publications

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“…It can be observed from Figure 5 that the hollow fiber made of pure PLA exhibited the largest strength. Generally, the maximum strength of the hollow fibers varied according to silk fibroin content because silk fibroin is more ductile than PLA 34 . The stress–strain curves and Young's modulus for the hollow fibers are shown in Figure 5B,C.…”

Section: Resultsmentioning

confidence: 99%

“…Generally, the maximum strength of the hollow fibers varied according to silk fibroin content because silk fibroin is more ductile than PLA. 34 The stress-strain curves and Young's modulus for the hollow fibers are shown in Figure 5B,C. As could be seen from Figure 5B, the hollow fiber prepared by pure PLA had the smallest strain, indicating its poor ductility.…”

Section: Mechanical Properties Of the Hollow Fibersmentioning

confidence: 94%

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Polylactic acid/silk fibroin composite hollow fibers as excellent controlled drug release systems

Gang

Wang

et al. 2022

Polymers for Advanced Techs

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Polylactic acid (PLA) and silk fibroin (SF) have been widely used in biomedical applications because of their excellent biocompatibility and degradability. In this study, PLA and SF were used as raw materials to prepare hollow fibers with a skin‐core structure by wet spinning technology. Scanning electron microscopy observations revealed that the structure of hollow fibers became increasingly uniform with increasing silk fibroin mass fraction. Tensile test results showed that with the increase of silk fibroin content, the elastic modulus of hollow fibers decreased and their tensile properties improved. The results of hollow fibers degradation experiments revealed that increasing the content of silk fibroin can effectively shorten the degradation time of hollow fibers. Ultraviolet spectrophotometry was used to measure the absorbance of tetracycline hydrochloride in phosphate buffer saline and calculate its release rate in hollow fibers with different silk fibroin contents, the result is HFs‐9 > HFs‐7 > HFs‐0 > HFs‐5 > HFs‐3. The PLA/SF controlled drug release system has precise controlled release of the drug, realizes the separation of the drug from the controlled release system, and solves the problem of sudden drug release. In addition, the controlled release system is non‐toxic, degradable, and has excellent mechanical properties.

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Section: Resultsmentioning

confidence: 99%

Section: Mechanical Properties Of the Hollow Fibersmentioning

confidence: 94%

Polylactic acid/silk fibroin composite hollow fibers as excellent controlled drug release systems

Gang

Wang

et al. 2022

Polymers for Advanced Techs

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“…In other words, alginate/gelatin can maintain the environment of the defect site and prevent bacterial invasion through its superstructure by delivering drugs. By combining the advantages of both layers, this double layer can be a good candidate for bone grafts. , The composition and structure of the bilayer scaffold were evaluated using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) in order to gain a thorough understanding of its physical and chemical characteristics and evaluate its biological efficacy in mandibular and femoral bone defect. Further analyses encompassed assessments of biodegradation, swelling ratio, and porosity.…”

Section: Introductionmentioning

confidence: 99%

Productizing Nano-Bioactive Glass-Based Bilayer Scaffolds: A Graft for Reconstruction of Mandibular and Femoral Bone Defects

Krishnamoorthy,

Purusothaman,

Subramanian

2024

ACS Appl. Mater. Interfaces

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This investigation aimed to construct a bilayer scaffold integrating alginate and gelatin with nanobioactive glass (BG), recognized for their efficacy in tissue regeneration and drug delivery. Scaffolds, namely, alginate/gelatin (AG), alginate-/actonel gelatin (AGD), alginate actenol/gelatin-45S5 BG (4AGD), and alginate-actonel/gelatin-59S BG (5AGD), were assembled using a cost-effective freeze-drying method, followed by detailed structural investigation via powder X-ray diffraction as well as morphological characterization using field emission scanning electron microscopy (FESEM). FESEM revealed a honeycomb-like morphology with distinct pore sizes for nutrient, oxygen, and drug transport. The scaffolds evidently exhibited hemocompatibility, high porosity, good swelling capacity, and biodegradability. In vitro studies demonstrated sustained drug release, particularly for scaffolds containing actonel. In vivo tests showed that the bilayer scaffold promoted new bone formation, surpassing the control group in bone area increase. The interaction of the scaffold with collagen and released ions improved the osteoblastic function and bone volume fraction. The findings suggest that this bilayer scaffold could be beneficial for treating critical-sized bone defects, especially in the mandibular and femoral regions.

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“…Traditional metallic materials such as stainless steel and alloy based on titanium are used in medical treatment. However, these materials are bioinert; i.e., they are not capable of forming a layer on their surface for fusion with natural bone. − …”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of TiO₂–SiO₂–P₂O₅/CaO/ZnO with a Core–Shell Structure for Bone Implantation

et al. 2022

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A facile synthesis method was developed to synthesize TiO 2 −SiO 2 −P 2 O 5 /CaO or TiO 2 −SiO 2 −P 2 O 5 /ZnO with a core−shell structure. The carboxylic cation exchanger Tokem-250 has a high selectivity for Ca 2+ /Zn 2+ ions and was used in this study. The framework of the material in the shell was TiO 2 −SiO 2 −P 2 O 5 , and the inner part was filled with CaO (sample TiO 2 −SiO 2 /CaO) or ZnO (sample TiO 2 −SiO 2 − P 2 O 5 /ZnO). A stepwise heat treatment (drying in a drying oven at 60 °C for 30 min, then annealing in a muffle furnace for 30 min at 150, 250, and 350 °C, at 600 °C for 6 h, and at 800 °C for 1 h) was needed to obtain a homogeneous material. The poly(vinyl alcohol) was used as a binding additive. The obtained composites were characterized by a regular structure and highly developed surface. The samples exhibit bioactive properties in the simulated body fluid (SBF) solution, since the surface contains active centers (Si 4+ , Ti 4+ ) which contribute to mineralization and precipitation of the calcium-phosphate compounds on the surface from biological media. The TiO 2 −SiO 2 −P 2 O 5 / CaO-PVA samples did not exceed acceptable hemolysis levels for medical materials.

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Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Abstract: The picture shows the preparation process of the cartilage scaffold, in which the hydrogel layer is loaded with aescin sodium, and the fiber layer is loaded with kartogenin.

Cited by 6 publications

References 68 publications

Polylactic acid/silk fibroin composite hollow fibers as excellent controlled drug release systems

Polylactic acid/silk fibroin composite hollow fibers as excellent controlled drug release systems

Productizing Nano-Bioactive Glass-Based Bilayer Scaffolds: A Graft for Reconstruction of Mandibular and Femoral Bone Defects

Facile Synthesis of TiO₂–SiO₂–P₂O₅/CaO/ZnO with a Core–Shell Structure for Bone Implantation

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Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Abstract: The picture shows the preparation process of the cartilage scaffold, in which the hydrogel layer is loaded with aescin sodium, and the fiber layer is loaded with kartogenin.

Cited by 6 publications

References 68 publications

Polylactic acid/silk fibroin composite hollow fibers as excellent controlled drug release systems

Polylactic acid/silk fibroin composite hollow fibers as excellent controlled drug release systems

Productizing Nano-Bioactive Glass-Based Bilayer Scaffolds: A Graft for Reconstruction of Mandibular and Femoral Bone Defects

Facile Synthesis of TiO2–SiO2–P2O5/CaO/ZnO with a Core–Shell Structure for Bone Implantation

Contact Info

Product

Resources

About

Facile Synthesis of TiO₂–SiO₂–P₂O₅/CaO/ZnO with a Core–Shell Structure for Bone Implantation