Preparation and Characterization of a Novel Co-processed Excipient of Chitin and Crystalline Mannitol

Daraghmeh, Nidal; Rashid, Iyad; Omari, Mahmoud M. H. Al; Leharne, Stephen A.; Chowdhry, Babur Z.; Badwan, Adnan A.

doi:10.1208/s12249-010-9523-8

Cited by 43 publications

(39 citation statements)

References 18 publications

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“…Melt granulation 10, 12, 15 , co-precipitation 16 , solvent evaporation method 6,17,18 , freeze-thaw technique, kneading method 19 , melt fusion method 14 , Spray-drying 7,9,20,21 , wet granulation [22][23] , spheronization 5 , co-milling 8,24 , and co-crystallization can be used for coprocessing. Melt granulation method include first melting of meltable polymer and add blend in it mixed properly followed by sieving of hot mass and then cooling.…”

Section: Methods Of Preparationmentioning

confidence: 99%

Untitled

2019

IJPSR

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Multifunctional excipients are class of excipients that includes pre-processed and co-processed excipients that provide added functionalities to the formulation. Functionality is a desirable property of the material that aids manufacturing and improves the quality and performance of the material. This review article reveals with the functionality evaluation of excipients that include surrogate functionality and explicit functionality of excipient. The surrogate functionality gives information that predicts whether or not a particular excipient is likely to have the requisite functionality to produce a product that will meet finished product specifications in all respects. The explicit functionality means the ability of excipient to develop an appropriate formulation of a drug and a useful manufacturing process to create a tablet. Compactibility of excipient is a capability of the material to form coherent agglomerates after compression, has been analyzed by compact density, tensile strength, solid fraction, bonding index, etc. The compatibility mainly depends upon the material property like plastic and elastic. QUICK RESPONSE CODE

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Section: Methods Of Preparationmentioning

confidence: 99%

Untitled

2019

IJPSR

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“…A combination of a plastic and brittle deforming material produces a co-processed excipient with desirable attributes for tableting (Wang et al, 2015). Many co-processing methods have been employed, including spray drying (Chauhan et al, 2016;Rojas and Kumar, 2011;Sharma et al, 2015), codrying (Mshelia et al, 2015;Olowosulu et al, 2011) wet massing, spheronisation, melt extrusion (Goyanes et al, 2011), co-precipitation (Kittipongpatana and Kittipongpatana 2011), co-grinding (Adeoye and Alebiowu, 2014a;Katsuno et al, 2013), wet-, dry-and spray-granulation (Daraghmeh et al, 2010) and coprocessing by crystal coating (Vanhoorne et al, 2014) among which spray drying is the most widely used and successful strategy (Rojas et al, 2012).…”

Section: Research Articlementioning

confidence: 99%

Comparative analysis of co-processed starches prepared by three different methods

Apeji¹,

Aluga²,

Olayemi³

et al. 2017

British Journal of Pharmacy

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Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that cogranulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of coprocessing influences the powder and tableting properties of the co-processed excipient.

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“…Proper control of various process parameters like inlet air temperature, outlet air temperature, atomization air pressure, flow rate, liquid viscosity and solid content in the feed can help in generating particles with desired characteristics. The ability for precise control over particle characteristics and ease of scale up has led to extensive use of spray-drying technology for the production of co-processed excipients 76,96 .…”

Section: Co-spray Dryingmentioning

confidence: 99%

Co-processing as a tool to improve aqueous dispersibility of cellulose ethers

Sharma

Modi

Bansal

2015

Drug Development and Industrial Pharmacy

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Cellulose ethers are important materials with numerous applications in pharmaceutical industry. They are widely employed as stabilizers and viscosity enhancers for dispersed systems, binders in granulation process and as film formers for tablets. These polymers, however, exhibit challenge during preparation of their aqueous dispersions. Rapid hydration of their surfaces causes formation of a gel that prevents water from reaching the inner core of the particle. Moreover, the surfaces of these particles become sticky, thus leading to agglomeration, eventually reducing their dispersion kinetics. Numerous procedures have been tested to improve dispersibility of cellulose ethers. These include the use of cross-linking agents, alteration in the synthesis process, adjustment of water content of cellulose ether, modification by attaching hydrophobic substituents and co-processing using various excipients. Among these, co-processing has provided the most encouraging results. This review focuses on the molecular mechanisms responsible for the poor dispersibility of cellulose ethers and the role of co-processing technologies in overcoming the challenge. An attempt has been made to highlight various co-processing techniques and specific role of excipients used for co-processing.

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Preparation and Characterization of a Novel Co-processed Excipient of Chitin and Crystalline Mannitol

Cited by 43 publications

References 18 publications

Untitled

Untitled

Comparative analysis of co-processed starches prepared by three different methods

Co-processing as a tool to improve aqueous dispersibility of cellulose ethers

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