Preparation and characterization of a new bio nanocomposites based poly(glycerol sebacic‐urethane) containing nano‐clay (Cloisite Na⁺) and its potential application for tissue engineering

Abstract

Nanocomposites containing clay nanoparticles often present favorable properties such as good mechanical and thermal properties. They frequently have been studied for tissue engineering (TE) and regenerative medicine applications. On the other hand, poly(glycerol sebacate) (PGS), a revolutionary bioelastomer, has exhibited substantial potential as a promising candidate for biomedical application. Here, we present a facile approach to synthesizing stiff, elastomeric nanocomposites from sodium‐montmorillonite nano‐clay (MMT) in the commercial name of Cloisite Na+ and poly(glycerol sebacate urethane) (PGSU). The strong physical interaction between the intercalated Cloisite Na+ platelets and PGSU chains resulted in desirable property combinations for TE application to follow. The addition of 5% MMT nano‐clay resulted in an over two‐fold increase in the tensile modulus, increased the onset thermal decomposition temperature of PGSU matrix by 18°C, and noticeably improved storage modulus of the prepared scaffolds, compared with pure PGSU. As well, Cloisite Na+ enhanced the hydrophilicity and water uptake ability of the samples and accelerated the in‐vitro biodegradation rate. Finally, in‐vitro cell viability assay using L929 mouse fibroblast cells indicated that incorporating Cloisite Na+ nanoparticles into the PGSU network could improve the cell attachment and proliferation, rendering the synthesized bioelastomers potentially suitable for TE and regenerative medicine applications.

Introducing photo-crosslinked bio-nanocomposites based on polyvinylidene fluoride/poly(glycerol azelaic acid)-g-glycidyl methacrylate for bone tissue engineering

“…At the same time, it reduces the elasticity of the scaffolds. A similar trend has been observed for the mechanical properties of polyester-based nanocomposites containing nHA and Cloisite Na + , such as poly(ε-caprolactone)/poly(glycerol succinic acid)/nHA, 20 poly(glycerol sebacic-urethane)/Cloisite Na + , 26 and poly(glycerol sebacic-urethane)/nHA. 18 It should be noted that the Young's modulus and UTS of PGAG/PVDF and its nanocomposites are within the range of those for the cancellous bone ( i.e.…”

“…An increase in cell viability and growth upon the addition of nHA and Cloisite Na + to the polymer matrix has also been reported in other literature. 18,20,26 Furthermore, it should be noted that higher cell proliferation on the surfaces of PGAG/ PVDF/nHA than PGAG/PVDF/Clay may also be due to the bioactivity and slight alkalinity of nHA, which could support the cell metabolic activity much more than Cloisite Na + . The optical microscopy images of MG-63 cell morphology cultured on the scaffolds and TCP for 5 days are shown in Fig.…”

“…Based on the literature, clay nanoparticles can enhance the mechanical and thermal properties, as well as the hydrophilicity of glycerol-based polyesters, to make them suitable for TE applications. 25,26 In the present study, it was assumed that the simultaneous presence of nHA and Cloisite Na + could yield a hybrid nanocomposite with enhanced biological and mechanical properties.…”

Harnessing the power of polyol-based polyesters for biomedical innovations: synthesis, properties, and biodegradation

“…In the first step, glycerol and sebacic acid react at elevated temperatures (usually Z120 1C) for a certain period. 52,53 This step is followed by a reduction in pressure, most commonly to around 40 mTorr, and the reaction continues for a few more hours. 54 This second step, also known as post-polymerization or cross-linking reaction, allows the formation of more cross-linked products.…”

Soybean oil‐based nanocomposites for dye adsorption: AESO‐chitosan‐graphene oxide synergy in water treatment

“…C-H stretching vibrations of CH 2 and CH 3 groups were detected at 2925 and 2852 cm À1 , respectively, while the C-H bending vibration appeared at 1458 cm À1 . [41][42][43] The carbonyl group band (C=O) was observed at 1730 cm À1 , and absorption bands at 1186 and 1046 cm À1 were attributed to C-O-C vibrations in the ester group. 44,45 Additionally, the peak at 810 cm À1 resulted from the epoxy band, and the absorption peak at 1630 cm À1 was assigned to the C=C bond.…”