Preparation and characterization of a curcumin nanoemulsion gel for the effective treatment of mycoses

Abstract

Fungal infections of skin including mycoses are one of the most common infections in skin or skins. Mycosis is caused by dermatophytes, non-dermatophyte moulds and yeasts. Various studies show different drugs to treat mycoses, yet there is need to treat it with applied drugs delivery. This study was designed to prepare a bio curcumin (CMN) nanoemulsion (CMN-NEs) for transdermal administration to treat mycoses. The self-nanoemulsification approach was used to prepare a nanoemulsion (NE), utilizing an oil phase consisting of Cremophor EL 100 (Cre EL), glyceryl monooleate (GMO), and polyethylene glycol 5000 (PEG 5000). Particle size (PS), polydispersity index (PDI), zeta potential (ZP), Fourier transform infrared (FTIR) spectrophotometric analysis, and morphological analyses were performed to evaluate the nanoemulsion (NE). The in vitro permeation of CMN was investigated using a modified vertical diffusion cell with an activated dialysis membrane bag. Among all the formulations, a stable, spontaneously produced nanoemulsion was determined with 250 mg of CMN loaded with 10 g of the oil phase. The average droplet size, ZP, and PDI of CMN-NEs were 90.0 ± 2.1 nm, − 7.4 ± 0.4, and 0.171 ± 0.03 mV, respectively. The release kinetics of CMN differed from zero order with a Higuchi release profile as a result of nanoemulsification, which also significantly increased the flux of CMN permeating from the hydrophilic matrix gel. Overall, the prepared nanoemulsion system not only increased the permeability of CMN but also protected it against chemical deterioration. Both CMN-ME (24.0 ± 0.31 mm) and CMN-NE gel (29.6 ± 0.25 mm) had zones of inhibition against Candida albicans that were significantly larger than those of marketed Itrostred gel (21.5 ± 0.34 mm). The prepared CMN-NE improved the bioavailability, better skin penetration, and the CMN-NE gel enhanced the release of CMN from the gel matrix on mycotic patients.

Potential of Curcumin in the Management of Skin Diseases

“…The aim of the next study was to prepare biocurcumin (CMN) nanoemulsion (CMN-NE) for transdermal administration in the treatment of mycoses. It was shown that the prepared CMN-NE improved bioavailability, with better skin penetration in patients with mycosis [109].…”

Application of 32 Factorial Design of Loratadine-Loaded Nanosponge in Topical Gel system: In Vitro, Ex Vivo, and In Vivo Assessments

“…The receptor compartment consists of 200 mL of pH 7.4 PBS taken in 250 mL beaker. The beaker was positioned over a magnetic stirrer, and 37 ± 0.5°C and 100 rpm were maintained as the study state constant [14]. At prede ned intervals (i.e., 0.25, 0.5, 0.75, 1, 2, 3, 4, 5, 6, 7 and 8 h), samples (1 mL) were removed and replaced with equivalent volumes of new PBS.…”

Application of 32 factorial design for loratadine-loaded nanosponge in topical gel formulation: comprehensive in-vitro and ex vivo evaluations

“…The receptor compartment consists of 200 mL of pH 7.4 PBS taken in 250 mL beaker. The beaker was positioned over a magnetic stirrer, and 37 ± 0.5 °C and 100 rpm were maintained as the study state constant 15 . At predefined intervals (i.e., 0.25, 0.5, 0.75, 1, 2, 3, 4, 5, 6, 7 and 8 h), samples (1 mL) were removed and replaced with equivalent volumes of new PBS.…”