Preparation and characterization of a imipramine-ß-cyclodextrin inclusion complex

Viswalingam, Muthusamy; Prabu, Samikannu; Sivakumar, K.; Rajamohan, R.

doi:10.1080/10739149.2016.1177726

Cited by 6 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Upon the addition of the further portions of βCD to compound Fc-4, the enhancement in the emission intensity of the resulting solution, as well as the blue shift, was observed. The similar changes in the fluorescence spectra have been previously demonstrated to be the characteristic features for the inclusion complex formation in cyclodextrin-based host–guest systems. − In our studies, a change in the emission intensity was not observed when the examined solution of compound Fc-4 was treated with d -glucose as the βCD monomer with no ability to complexation…”

Section: Resultssupporting

confidence: 88%

Supramolecular Interactions between β-Cyclodextrin and the Nucleobase Derivatives of Ferrocene

Kasprzak

Koszytkowska‐Stawińska

Nowicka

et al. 2019

J. Org. Chem.

View full text Add to dashboard Cite

Novel conjugates of ferrocene with uracil, 5-fluorouracil, tegafur, or acyclovir are reported. Their synthesis involved (i) the azide–alkyne 1,3-dipolar cycloaddition or (ii) the formation of the ester linkage. For the first time, we present an in-depth insight into the supramolecular interactions between β-cyclodextrin and ferrocene-nucleobase derivatives. Spectroscopic and voltammetric analyses performed within this work suggested that the ferrocene or adamantane unit of the conjugates interacted with the β-cyclodextrin’s inner cavity. The methods applied for the supramolecular studies included 1H–1H ROESY NMR, 1H NMR titration, Fourier-transform infrared spectroscopy, cyclic voltammetry, fluorescence spectra titration, and 1H DOSY NMR. 1H DOSY NMR was also employed to evaluate the apparent binding constants for all the complexes. The ferrocene–acyclovir conjugate Fc-5 featured the highest apparent binding constant value among all the complexes tested.

show abstract