Preparation and characterization of acrylic bone cement with high drug release

Angiogenic Rg1/Sr-Doped TiO2Nanowire/Poly(Propylene Fumarate) Bone Cement Composites

“…Therefore, bone cement composites exhibited extraordinary mechanical reinforcement exceeding the enhancements observed for the mechanically mixed bone cement composites at the same loading. It has been reported that drug‐loaded cement is mechanically less strong than plain cement . However, our results showed that plain bone cement displays only a slightly better flexural and tensile strengths than those of the ginsenoside Rg 1 ‐loaded bone cement.…”

Role of Cross-Linking Process on the Performance of PMMA

“…The outcome of the point of cross-linking on swelling and drug swelling and drug release behavior of poly (MMA-coitaconic acid) [P (MMA/IA)] hydrogels for site specific drug distribution has been presented by Khalid S et al [32] putting in consideration that the Cross-linking percentage is one of the most significant factors that affect the swelling of the hydrogels, in which any increase occur in the degree of cross-linking of the system will effect in a stronger gel, also it was detected that the MMA/IA polymer is appropriate for distributing the drug above pH 6, whatever the degree of cross-linking [32] . In literature there is a work presented by Nein et al [33] stating that bone cement is produced for drug release with the ability of control, and an increase in both the drug release rate and total release amount of the drugs, devoid of losing the mechanical characteristics of the cement, and that was accomplished by acquainting with crosslinked PMMA-acrylic acid sodium salt particles into the bone cement, that intensify the hydrophilicity of the cement for the easy channel of liquids [33].…”

Acrylic Bone Cements: The Role of Nanotechnology in Improving Osteointegration and Tunable Mechanical Properties

“…The reason why this particular copolymer was chosen is that its mechanical properties and in vitro bioactivity were evaluated in a previous study, [63][64][65] showing its potential for orthopedic applications. On the other hand, Nien et al 66 salt) particles in order increase drug release. The authors reported that the drug-loaded bone cement had enhanced hydrophilicity, which allowed the efficient motion of fluids through the cement, and supplement both the drug release rate and total release amounts of drugs.…”

“…Lowering the temperature prior to bone cement mixing, 157 pre-cooling the femoral prosthesis before implantation into the bone cavity, 157 158 using pre-chilled water to pulse-lavage the bone cavity prior to placement of cement 159 or preparing bone cement under vacuum 156 have significant effect on peak temperature at the cement-bone interface. Bone cements loaded with additives, such as fibers, [160][161][162] mineral particles, 151 163 polymers, 24 or drugs, 66 are reported. Additionally, modifications to biocompatible materials in order to enhance their osteogenic potencial have been described.…”