Preparation and Characterization of Avermectin B2 Microcapsules and Effective Control of Root-Knot Nematodes

Wang, Liying; Yan, Xinxin; Li, Yan; Gao, Chong; Liu, Junzhi

doi:10.1021/acsomega.3c00244

Cited by 10 publications

(6 citation statements)

References 46 publications

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“…These results confirm the superior control effect exhibited by the lambda-cyhalothrin microcapsules compared with the lambda-cyhalothrin EC at the same dosage. It showed that microcapsules can prolong the persistent period of insecticides and reduce the number of drugs, which provides a new direction for market development of pesticides. , …”

Section: Resultsmentioning

confidence: 99%

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Preparation, Characterization, and Bioactivity Evaluation of Lambda-Cyhalothrin Microcapsules for Slow-Controlled Release System

Wang,

Liu,

Gao

et al. 2024

ACS Omega

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The utilization of interfacial polymerization in the preparation of microcapsules with a slow-controlled release has been shown to effectively improve pesticide efficacy and reduce environmental pollution. In this study, polyurea microcapsules loaded with lambda-cyhalothrin were prepared by an interfacial polymerization method using modified isocyanate (MDI) as the wall material and GT-34 as the initiator. The microcapsules were fully characterized by optical microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, etc., and release behaviors were investigated. The results indicated that the microcapsules had a smooth surface and uniform distribution, the average particle size of the microcapsules was 1.97 μm, and the encapsulation efficiency of lambda-cyhalothrin microcapsules could reach 91.48%. Compared with other commercial formulations, the microcapsules exhibited an excellent sustained release property (>7 days) in a 50% acetonitrile aqueous solution (v/v). Subsequently, in vitro release studies showed that the lambda-cyhalothrin microcapsules could consistently control the release of the core materials at different pH, temperature, and MDI addition amount conditions. The release of lambda-cyhalothrin microcapsules was in accordance with the first-order model release, which was mainly by the Fickian diffusion mechanism. Furthermore, the biological activity on Myzus persicae showed that the microcapsules’ persistence period was above 21 days, which was longer than that for the emulsifiable concentrate formulation.

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Section: Resultsmentioning

confidence: 99%

“…It showed that microcapsules can prolong the persistent period of insecticides and reduce the number of drugs, which provides a new direction for market development of pesticides. 21 , 37 …”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization, and Bioactivity Evaluation of Lambda-Cyhalothrin Microcapsules for Slow-Controlled Release System

Wang,

Liu,

Gao

et al. 2024

ACS Omega

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“…Liu et al developed a novel crystallization device and investigated the effects of variable parameters on crystal size and crystal size distribution (CSD) of dolutegravir sodium . Furthermore, microfluidics has been reported to hold great potential for the production of monodisperse spherical particles and pesticide microcapsules. − Despite the numerous advantages of microfluidic crystallization, research on microfluidics for oiling-out crystallization is still limited and remains an underexplored area.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Crystallization for Screening of Spherical Particles of Pyraclostrobin

Zhong,

Guo,

Bao

2024

Ind. Eng. Chem. Res.

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The semicontinuous antisolvent crystallization process of pyraclostrobin was investigated utilizing an integrated microfluidic device that encompasses both microfluidic channels and an agitated crystallizer. We successfully regulated the crystal morphology as quasi-spherical particles and narrowed the particle size distribution compared with that of the raw materials. We explored the impact of ultrasound powers, initial concentration, antisolvent content, and stirring rate on crystal morphology. Our innovative approach involves precisely manipulating the stirring rate and solvent content, resulting in diverse crystal morphologies. Notably, we unveil two distinct mechanisms governing the formation of spherical particles, which can be attributed to the variability in the oil droplet sizes. Our apparatus and approach enable the efficient screening of spherical particles, advocating minimal reagent consumption. This achievement holds the potential to be scaled across a variety of fields ranging from pharmaceuticals to material science.

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“…The potato rot nematode, Ditylenchus destructor Thorne, is a soil parasite with strong ability to destroy roots of crops, such as sweet potato, potato, and Chinese medicinal plants, − posing a serious threat to global food security. , As an example, the potato rot nematode causes a 20–30% reduction in crop yield, resulting in economic losses amounting to several billion dollars annually . Unfortunately, there are only a few chemicals that are effective against the nematode.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembly Mechanism of Avermectin B1a and Its Activity against Potato Rot Nematode

Xu,

Chu,

Pan

et al. 2024

ACS Agric. Sci. Technol.

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Many of the carriers used in the delivery of avermectin (Avm) B1a, a widely used crop pesticide, may lead to environmental safety problems. Here, we tested the self-assembly of Avm B1a without an exogenous excipient for improved environmental safety and drug activity. Our results showed that various solvents, including ethanol, methanol, acetone, dimethyl sulfoxide, and N,N-dimethylformamide, can be used to prepare Avm B1a self-assembled nanoparticles. Nuclear magnetic titration experiments revealed that the intermolecular hydrogen bond was the main binding force in Avm B1a self-assembly. Molecular dynamics simulations indicated that the number of hydrogen bonds increased to 10 and 20 in the assembly system of 16 and 32 Avm B1a molecules, respectively, over a period of 500 ns. The assembled Avm B1a presented a structured spherical shape, and particle size could be effectively regulated with the initial concentration. The permeability in soil and anti-UV degradation capacity were, respectively, 3.5 and 2.0 times higher for self-assembled nanoparticles with a size of 128 nm than for pure Avm B1a. The activity of nanoparticles against potato putrid stem nematode was higher than that of pure Avm B1a; in that, particles with a size of 128 nm exhibited the highest activity, and the 24 h and 48 h activity was, respectively, 16 and 20% higher than that of pure Avm B1a. In vivo fluorescence experiments showed that the fluorescence in nematodes increased with the increase in chemical concentration and time.

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Preparation and Characterization of Avermectin B2 Microcapsules and Effective Control of Root-Knot Nematodes

Cited by 10 publications

References 46 publications

Preparation, Characterization, and Bioactivity Evaluation of Lambda-Cyhalothrin Microcapsules for Slow-Controlled Release System

Preparation, Characterization, and Bioactivity Evaluation of Lambda-Cyhalothrin Microcapsules for Slow-Controlled Release System

Microfluidic Crystallization for Screening of Spherical Particles of Pyraclostrobin

Self-Assembly Mechanism of Avermectin B1a and Its Activity against Potato Rot Nematode

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