Preparation and characterization of biodegradable nanospheres composed of methoxy poly(ethylene glycol) and dl-lactide block copolymer as novel drug carriers

Kim, So Yeon; Shin, Il Gyun; Lee, Young Moo

doi:10.1016/s0168-3659(98)00083-2

Cited by 107 publications

(45 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, CAC values slightly decreased with decreasing hydrophilic PVP fragment molecular weight and dramatically decreased with increasing hydrophobic anchor chain length. Obtained data fully corresponds with results of other investigators (31,32), reporting that the micellization process is determined mainly by the nature and the length of the hydrophobic block, where the nature of soluble hydrophilic block has only a slight effect on the onset of micelle formation.…”

Section: ------------------------------------------------------------supporting

confidence: 88%

Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal anti-inflammatory drugs: Characterization and in vitro controlled release of indomethacin

Tsatsakis¹

2010

Int J Mol Med

View full text Add to dashboard Cite

Abstract. Novel amphiphilic poly-N-vinylpyrrolidone derivatives with different molecular weight of hydrophilic PVP fragment and one secondary di-n-alkyl terminal hydrophobic fragment of different length were synthesized to compare their inclination for formation of nano-scaled micelle-like aggregates in aqueous media with previously studied primary n-alkyl terminated poly-N-vinylpyrrolidones. The behavior of amphiphilies in water solutions was studied and critical aggregation concentration values for prepared polymer samples were determined by fluorescence spectroscopy and compared with those for primary n-alkyl derivatives. Polymeric micelle-like particles with or without encapsulated drug were prepared using dialysis or solvent evaporation techniques. Indomethacin was incorporated into hydrophobic inner core of these nanoparticles as a typical model drug. Dynamic light-scattering studies determined that the average size of particles formed was from 90 nm up to 600 nm with monodisperse size distribution and the nanoparticle size slightly increased with the amount of indomethacin encapsulated into inner core of the particles. In vitro release experiments carried out at different medium pH values using indomethacin-loaded nanoparticles exhibited slow and steady drug release into the medium.

show abstract

Section: ------------------------------------------------------------supporting

confidence: 88%

Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal anti-inflammatory drugs: Characterization and in vitro controlled release of indomethacin

Tsatsakis¹

2010

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…[28][29][30][31] All the CMC values were low enough (0.52-1.8 × 10 −8 mol/L) to maintain thermodynamic stability of micelles after intravenous injection which induced severe dilution. 32,33 Physicochemical characterization of micelles…”

Section: Characterization Of Peg-plasmentioning

confidence: 99%

Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG–PLA micelle

Shi

Huang²,

Liang³

et al. 2012

IJN

View full text Add to dashboard Cite

Abstract:To improve the pharmacokinetics and stability of recombinant human erythropoietin (rhEPO), rhEPO was successfully formulated into poly(ethylene glycol)-poly(d,l-lactide) (PEG-PLA) di-block copolymeric micelles at diameters ranging from 60 to 200 nm with narrow polydispersity indices (PDIs; PDI , 0.3) and trace amount of protein aggregation. The zeta potential of the spherical micelles was in the range of −3.78 to 4.65 mV and the highest encapsulation efficiency of rhEPO in the PEG-PLA micelles was about 80%. In vitro release profiles indicated that the stability of rhEPO in the micelles was improved significantly and only a trace amount of aggregate was found. Pharmacokinetic studies in rats showed highly enhanced plasma retention time of the rhEPO-loaded PEG-PLA micelles in comparison with the native rhEPO group. Increased hemoglobin concentrations were also found in the rat study. Native polyacrylamide gel electrophoresis results demonstrated that rhEPO was successfully encapsulated into the micelles, which was stable in phosphate buffered saline with different pHs and concentrations of NaCl. Therefore, PEG-PLA micelles can be a potential protein drug delivery system.

show abstract

“…During the past decades, much attention has been paid to the biodegradable polymers due to the environmental significance [1] and their important biomedical and pharmaceutical applications, particularly in drug delivery matrices, wound healing and tissue reconstruction [2,3].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of depsipeptides from L-amino acids and lactones

Cao

Feng

Wang

et al. 2011

Front. Chem. Sci. Eng.

View full text Add to dashboard Cite

By using the corresponding L-amino acid sodium as initiator, ε-caprolactone-depsipeptides CL-Ala and CL-Leu were prepared by the reactions of ε-caprolactone (CL) with L-alanine and L-leucine, respectively, and p-dioxanone-depsipeptide (PDO-Leu) was prepared by the reaction of p-dioxanone (PDO) with Lleucine. Two poly(ε-caprolactone) oligomers (PCL-Ala and PCL-Leu) of different molecular weights with depsipeptide unit were synthesized by controlling the feed ratio of L-amino acid sodium and CL. The presence of the depsipeptide structure in these obtained products was confirmed by 1 H NMR spectra and the molecular weight of the poly(ε-caprolactone) oligomers was measured by gel permeation chromatography (GPC). These products contain a hydroxyl group and a carboxyl group in one molecule, which means they could act as bifunctional monomers for further polymerization to prepare high molecular weight polymers. By this way, the depsipeptide unit could be introduced into the polymers and the biodegradation rates of the novel polymers could be well controlled in vivo by the tailored molecular structures.

show abstract

Preparation and characterization of biodegradable nanospheres composed of methoxy poly(ethylene glycol) and dl-lactide block copolymer as novel drug carriers

Cited by 107 publications

References 30 publications

Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal anti-inflammatory drugs: Characterization and in vitro controlled release of indomethacin

Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal anti-inflammatory drugs: Characterization and in vitro controlled release of indomethacin

Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG–PLA micelle

Synthesis of depsipeptides from L-amino acids and lactones

Contact Info

Product

Resources

About

Preparation and characterization of biodegradable nanospheres composed of methoxy poly(ethylene glycol) and dl-lactide block copolymer as novel drug carriers

Cited by 107 publications

References 30 publications

Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal anti-inflammatory drugs: Characterization and in vitro controlled release of indomethacin

Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal anti-inflammatory drugs: Characterization and in vitro controlled release of indomethacin

Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG&ndash;PLA micelle

Synthesis of depsipeptides from L-amino acids and lactones

Contact Info

Product

Resources

About

Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG–PLA micelle