Preparation and characterization of biodegradable nanocomposites derived from carboxymethyl cellulose and hydroxyapatite

Azzaoui, Kamal; Mejdoubi, E.; Lamhamdi, A.; Jodeh, Shehdeh; Hamed, Othman; Aziz, Mohammed; Jerdioui, S.; Salghi, R.; Akartasse, N.; Errich, A.; Ríos, Ángel; Zougagh, Mohammed

doi:10.1016/j.carbpol.2017.02.092

Cited by 54 publications

(33 citation statements)

References 18 publications

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“…The Korsmeyer and Peppas kinetic model is used to describe the first 60 wt % of the release behavior of a hypothetical distribution that attempts to explain release mechanisms where erosion or dissolution of the matrix occurs and is represented as follows: 49,50 M t M 1 5k kp t n (9) where M t /M 1 is the cumulative release content of IBU in a time interval t (min); k 0 (min 21 ), k 1 (min 21 ), k H (min 21/2 ), and k kp (min -n ) are the constant release rates of the four kinetic models, respectively; C 0 , C 1 , and C H are the intercepts of eqs. (6) to (9), respectively; and n is an exponent that indicates the mechanism by which the drug release process occurs.…”

Section: Grafting Content Of Cd1 Deta-b-cd and B-cd By The Double-nmentioning

confidence: 99%

“…CMC is an anionic, water‐soluble cellulose derivative obtained by introducing CH 2 COOH groups into cellulose molecular chains. HEC also has excellent water solubility and biocompatibility . Based on these advantages, these two cellulose derivatives are suited for preparing transparent and homogeneous double‐network hydrogels for drug delivery and tissue engineering materials …”

Section: Introductionmentioning

confidence: 99%

“…HEC also has excellent water solubility and biocompatibility. 9,10 Based on these advantages, these two cellulose derivatives are suited for preparing transparent and homogeneous double-network hydrogels for drug delivery and tissue engineering materials. [11][12][13] Two kinds of hydrophilic polymers can form a double-network hydrogel structure, which, despite containing 90% water, have an elastic modulus of a few to several tens of megapascals.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of cellulosic drug‐loaded hydrogel beads through electrostatic and host–guest interactions

Wang

2018

J of Applied Polymer Sci

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Cyclodextrin‐grafted cellulosic hydrogel beads (CD+@HEC‐CMC‐gel) were prepared through electrostatic and host–guest interactions. β‐Cyclodextrin (CD+) modified with quaternary ammonium groups was used as the electropositive binding site, and carboxymethyl cellulose (CMC) in a double‐network hydrogel structure was used as the electronegative binding site. The double‐network structure was obtained by controlling the crosslinking of CMC and hydroxyethyl cellulose (HEC) in the presence of epichlorohydrin. The electrostatic interaction was used to graft CD+ onto the electronegative double‐network structure. Scanning electron microscopy indicated an obvious change in the cellulosic double network after grafting of CD+. The grafting content of CD+ in CD@HEC‐CMC‐gel is determined as 93.10 ± 0.74% by the photometric titration method. In order to evaluate the assembling and releasing ability, ibuprofen (IBU) was selected to be encapsulated in CD+@HEC‐CMC‐gel by host–guest interaction. In addition, the release of IBU by the hydrogel beads was explained by several kinetic models. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46593.

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Section: Grafting Content Of Cd1 Deta-b-cd and B-cd By The Double-nmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of cellulosic drug‐loaded hydrogel beads through electrostatic and host–guest interactions

Wang

2018

J of Applied Polymer Sci

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“…Lately, an increasing interest about the synthesis of polymeric composites based on cellulose derivatives and micro or nanohydroxyapatite particles, especially for applications in osteointegration has been established. This is mainly because, through hydrolysis in the body, cellulose breaks down, releasing glucose, with no adverse effect on the organism [15,16]. These investigations were based on the compatibility between derivatives of cellulose and hydroxyapatite [17], the influence on the properties of the polymers [18] and improvement in the capacity to remove pollutants using cellulose derivatives.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of cellulose acetate-hydroxyapatite micro and nano composites membranes for water purification and biomedical applications

Pandele

Comanici

Carp

et al. 2017

Vacuum

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In this work, we report facile synthesis and characterization of new cellulose acetatehydroxyapatite membranes for water purification and biomedical applications. The membranes were synthesized from a polymer solution in N, N'-dimethylformamide (12% wt.) where different concentrations of hydroxyapatite (1, 2, 4% wt. based on the amount of polymer) were dispersed using sonication. The synthesis of membranes was carried out by precipitation employing phase inversion using deionized water. The morphological and structural characterization of the synthesized membranes was carried out using SEM, EDS and FT-IR. Thermal characterization (TGA & DTG) and water flows analysis of the synthesized membranes was also carried out. The SEM analysis confirmed the presence of hydroxyapatite micro/nanostructured particles in the membrane as well as significant changes in the morphology of the membranes surface. The presence of inorganic compounds was also found to influence the thermal or hydrodynamic properties of the composite membranes,

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“…Sodium carboxymethylcellulose (CMC) is a kind of nontoxic, biocompatible, biodegradable, and rigid material . Given its stiffness, CMC is added to hydrogels to improve their moduli.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of graphene oxide and sodium carboxymethylcellulose on the properties of poly(vinyl alcohol) hydrogels

Xue

Cai

et al. 2019

J of Applied Polymer Sci

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Hydrogels are a promising candidate for applications in biomedicine and bioengineering, but their mechanical properties often restrict their applications. To improve the mechanical performance of poly(vinyl alcohol) (PVA) hydrogels, we introduced sodium carboxymethylcellulose (CMC), and graphene oxide (GO) into them. We prepared a series of composite hydrogels composed of PVA, CMC, and GO with epichlorohydrin as a chemical crosslinker. We used Fourier transform infrared spectroscopy and X-ray diffraction to characterize the chemical structures of GO and the hydrogel. The dynamic mechanical analysis results show the synergistic enhancement effects of CMC and GO on the PVA hydrogel. The swelling process of the hydrogels also fit well with the second-order kinetic equation. Scanning electron microscopy results suggest that the neat mesh structure facilitated superior mechanical properties in the hydrogels.

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Preparation and characterization of biodegradable nanocomposites derived from carboxymethyl cellulose and hydroxyapatite

Cited by 54 publications

References 18 publications

Preparation of cellulosic drug‐loaded hydrogel beads through electrostatic and host–guest interactions

Preparation of cellulosic drug‐loaded hydrogel beads through electrostatic and host–guest interactions

Synthesis and characterization of cellulose acetate-hydroxyapatite micro and nano composites membranes for water purification and biomedical applications

Synergistic effect of graphene oxide and sodium carboxymethylcellulose on the properties of poly(vinyl alcohol) hydrogels

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