Preparation and characterization of boron-based bioglass by sol−gel process

Furlan, Roberto Gustavo; Correr, Wagner Rafael; Russi, Ana Flavia Costa; Iemma, Mônica Rosas da Costa; Trovatti, Eliane; Pécoraro, Édison

doi:10.1007/s10971-018-4806-8

Cited by 22 publications

(12 citation statements)

References 29 publications

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“…Finally, a thermal treatment is required to dry the sol and make oxide formation and organic removal possible. This manufacturing process offers the advantage of better control of the composition and product homogeneity than traditional quenching methods [ 77 ]. Furthermore, sol–gel-type bioactive glasses have a greater surface area and higher porosity (mesoporous volume in mesoporous bioactive glasses) than melt-derived glasses having the same composition: glasses produced by sol–gel methods will be characterized by a higher degree of interaction with the surrounding environment and degradation, which results in more efficient bioactivity [ 63 , 69 , 78 , 79 ].…”

Section: Bioactive Glassesmentioning

confidence: 99%

Bioactive Glass Applications: A Literature Review of Human Clinical Trials

et al. 2021

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The use of bioactive glasses in dentistry, reconstructive surgery, and in the treatment of infections can be considered broadly beneficial based on the emerging literature about the potential bioactivity and biocompatibility of these materials, particularly with reference to Bioglass® 45S5, BonAlive® and 19-93B3 bioactive glasses. Several investigations have been performed (i) to obtain bioactive glasses in different forms, such as bulk materials, powders, composites, and porous scaffolds and (ii) to investigate their possible applications in the biomedical field. Although in vivo studies in animals provide us with an initial insight into the biological performance of these systems and represent an unavoidable phase to be performed before clinical trials, only clinical studies can demonstrate the behavior of these materials in the complex physiological human environment. This paper aims to carefully review the main published investigations dealing with clinical trials in order to better understand the performance of bioactive glasses, evaluate challenges, and provide an essential source of information for the tailoring of their design in future applications. Finally, the paper highlights the need for further research and for specific studies intended to assess the effect of some specific dissolution products from bioactive glasses, focusing on their osteogenic and angiogenic potential.

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Section: Bioactive Glassesmentioning

confidence: 99%

Bioactive Glass Applications: A Literature Review of Human Clinical Trials

et al. 2021

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“…They begin to disintegrate and release Ca 2+ , PO 4 3+ , and SiO 4 4+ as soon as they were immersed in simulated body fluid (SBF), as confirmed by an inductively coupled plasma‐atomic emission spectrometer (Figure S6, Supporting Information). Since Ca 2+ and PO 4 3+ formed hydroxyapatite, their concentrations dropped after the initial rapid release, confirming the bioactivity and biodegradability of the MBG spheres …”

mentioning

confidence: 63%

“…OMP and OMC were prepared according to the literatures . The preparation process of the MBG microspheres was similar with the reported ones . TEOS (99%; Aladdin), Ca(NO 3 ) 2 ·4H 2 O (0.47 g), Fe(NO 3 ) 3 ·9H 2 O (0.3 g), HNO 3 (2 m , 0.04 g), and Pluronic F127 (1.8 g) were dissolved in 4 g of absolute ethanol, being stirred at room temperature until the solution was clear.…”

Section: Methodsmentioning

confidence: 99%

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Engineering the Structure of Mesoporous Bioactive Glass Microspheres by the Surface Effect of Inverse Opal Templates and Temperature

Gong

et al. 2019

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Mesoporous materials have great application value in the fields of supercapacitors, [1] catalyst, [2] optical materials, [3] chromatographic separation, and drug delivery. [4,5] Most of mesoporous materials are prepared by self-assembly of various ionic and block copolymer surfactants, [6,7] which can form a variety of selfassembled structures, [8] from spherical or rod-shaped micelles,The interactions of ions and molecules with material surface are highly dependent on the surface properties of the material. Therefore, the distribution of ions or molecules near the material surface may be affected by the surface properties. This phenomenon can be significant enough for controlling the structure of a material synthesized in the sub-micrometer scale confinement space of a template. This work confirms that inverse opals are perfect templates for offering confinement space, while their different surface properties can strongly affect ion and block copolymer distribution in the confinement space. This surface effect principle can be used for the controlled synthesis of colloids with complex composition. As an example, four kinds of mesoporous magnetic bioactive glass colloids with ordered mesopores, coreshell structure, open surface pores, or disordered mesopores are prepared by using polystyrene and carbon inverse opal templates. This work reveals that inverse opal templates possess great advantage in controlled synthesizing colloidal structures due to their surface effect on ions and molecules and confinement space.to hexagonal packed liquid crystal phase, 3D bicontinuous phase, [9,10] and 2D layered phase. [11,12] Many methods have been used to prepare mesoporous particles of different structures in the past 30 years. For example, hollow mesoporous silica spheres were prepared by emulsion chemistry [13] and template synthesis methods, [14] and solid mesoporous microspheres were prepared by an aerosol means. [15] Micrometer-and sub-micrometer-size mesoporous silica microspheres were prepared with well-controlled uniform size. [16] Core-shell silica microspheres with solid core and mesoporous shell were prepared by using silica microspheres as a template. [17] Although many achievements have been obtained, in recent years, the development of theoretical and experimental research on mesoporous materials is relatively slow.Mesoporous bioactive glasses (MBG) are promising materials for drug carrier and tissue engineering. [18] They have better biodegradable and biocompatible properties than pure mesoporous silica due to additional ions in silica network; they are more robust and have higher specific surface area and pore volume than polymer and peptide drug carriers. Many metal ions are doped into BGs to expand their application. Boron-doped Bioglass 45S5 (45.0SiO 2 ·24.5Na 2 O·24.5CaO·6.0P 2 O 5 , wt%) has better biological activity due to its faster dissolution than silicate glasses and almost complete conversion to hydroxyapatite (HA). [19] Adding Zn 2+ , Ag + , or Cu 2+ can endow BG with well antimicrobial activity....

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“…This mechanism contributes to the nano-bioglass degradation, while promoting bone formation. Even their degradation depends on their composition and nanostructure and can be tailored from days to months; for example, borate-based bioglasses have been shown to degrade much faster than silicate varieties ( Balasubramanian et al, 2018 ; Furlan et al, 2018 ). Recent studies showed that increasing the surface area and porosity of nanostructured bioglasses can greatly accelerate their biodegradation, as well as biointegration ( Kong et al, 2018 ).…”

Section: Mimicking Bone Composition: Bioceramics and Composite Nanostmentioning

confidence: 99%

Nanostructured Biomaterials for Bone Regeneration

Lyons

Plantz

Hsu

et al. 2020

Front. Bioeng. Biotechnol.

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This review article addresses the various aspects of nano-biomaterials used in or being pursued for the purpose of promoting bone regeneration. In the last decade, significant growth in the fields of polymer sciences, nanotechnology, and biotechnology has resulted in the development of new nano-biomaterials. These are extensively explored as drug delivery carriers and as implantable devices. At the interface of nanomaterials and biological systems, the organic and synthetic worlds have merged over the past two decades, forming a new scientific field incorporating nano-material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions and influence function, while also considering safety. While there is still much to learn about the bio-physicochemical interactions at the interface, we are at a point where pockets of accumulated knowledge can provide a conceptual framework to guide further exploration and inform future product development. This review is intended as a resource for academics, scientists, and physicians working in the field of orthopedics and bone repair.

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Preparation and characterization of boron-based bioglass by sol−gel process

Cited by 22 publications

References 29 publications

Bioactive Glass Applications: A Literature Review of Human Clinical Trials

Bioactive Glass Applications: A Literature Review of Human Clinical Trials

Engineering the Structure of Mesoporous Bioactive Glass Microspheres by the Surface Effect of Inverse Opal Templates and Temperature

Nanostructured Biomaterials for Bone Regeneration

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