Preparation and characterization of cationic pullulan-based polymers with hydrophilic or amphiphilic characteristics for drug delivery

Carvalho, Layde T.; Teixeira, Ana Julia R.M.; Moraes, Rodolfo M.; Barbosa, Rennan F. S.; Queiroz, Rafaela C.; Tada, Dayane Batista; Mulinari, Daniella Regina; Rosa, Derval S.; Ré, Maria Inês; Medeiros, Sebastião Freitas de

doi:10.1016/j.reactfunctpolym.2022.105441

Cited by 12 publications

(5 citation statements)

References 56 publications

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“…As a second step, chemical modification of the functional side-groups via etherification, esterification, amination, or amidation and the introduction of a CTA makes them available for further RAFT polymerization. In this way, the polysaccharide works as a backbone, while the CTA-modified side-groups can be utilized for the grafting of additional polymer chains comprising different monomers [16,[41][42][43].…”

Section: Graft Copolymersmentioning

confidence: 99%

Using RAFT Polymerization Methodologies to Create Branched and Nanogel-Type Copolymers

Skandalis,

Sentoukas,

Selianitis

et al. 2024

Materials

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This review aims to highlight the most recent advances in the field of the synthesis of branched copolymers and nanogels using reversible addition-fragmentation chain transfer (RAFT) polymerization. RAFT polymerization is a reversible deactivation radical polymerization technique (RDRP) that has gained tremendous attention due to its versatility, compatibility with a plethora of functional monomers, and mild polymerization conditions. These parameters lead to final polymers with good control over the molar mass and narrow molar mass distributions. Branched polymers can be defined as the incorporation of secondary polymer chains to a primary backbone, resulting in a wide range of complex macromolecular architectures, like star-shaped, graft, and hyperbranched polymers and nanogels. These subcategories will be discussed in detail in this review in terms of synthesis routes and properties, mainly in solutions.

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Section: Graft Copolymersmentioning

confidence: 99%

Using RAFT Polymerization Methodologies to Create Branched and Nanogel-Type Copolymers

Skandalis,

Sentoukas,

Selianitis

et al. 2024

Materials

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“…In vitro cell tests showed no cytotoxicity even after prolonged exposure of the polymers to L929 MEF cells, which is a promising result for the future use of the copolymers as drug delivery systems. The development of cationic PULL-DEAE and PULL-DEAE-gPZLL by the methods described in this study is an important contribution to future research on the use of hydrophilic and hydrophobic pullulan derivatives for various controlled drug release devices, such as orodispersible films, solid particle suspensions for oral and topical administration, and particles in aqueous suspensions for intravenous administration [ 116 ].…”

Section: Overview On Polysaccharide-based Drug Delivery Systemsmentioning

confidence: 99%

“…By increasing its solubility in organic solvents or enriching it with new reactive functional groups, pullulan nonreducing agent, water solubility, formation of oxygen-impermeable films, hygroscopicity, biodegradability, and viscosity can be improved [ 116 ].…”

Section: Overview On Polysaccharide-based Drug Delivery Systemsmentioning

confidence: 99%

“…NMR confirmed the graft copolymerization, and the degree of substitution for each copolymer ranged from 0.13 to 0.63. These findings suggest that the physicochemical properties of PULL-DEAE and PULL-DEAE-g-PZLL could broaden the potential applications of modified pullulan in fields such as drug delivery in the pharmaceutical industry [ 116 ].…”

Section: Overview On Polysaccharide-based Drug Delivery Systemsmentioning

confidence: 99%

“…For example, in Ref. [116], cationic pullulan-based polymers for drug delivery with hydrophilic or amphiphilic properties were prepared and characterized. All the polymers were analyzed for their chemical composition, molar mass, thermal properties, critical aggregation concentration, and Pullulan is a type of homopolysaccharide that is composed of α-(1→4)-maltotriosyl (3-D-glucopyranosyl) units that are linked by α-(1→6) bonds.…”

Section: Pullulan-based Coatings As Drug Delivery Systemsmentioning

confidence: 99%

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Polysaccharide-Based Coatings as Drug Delivery Systems

Visan,

Cristescu

2023

Pharmaceutics

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Therapeutic polysaccharide-based coatings have recently emerged as versatile strategies to transform a conventional medical implant into a drug delivery system. However, the translation of these polysaccharide-based coatings into the clinic as drug delivery systems still requires a deeper understanding of their drug degradation/release profiles. This claim is supported by little or no data. In this review paper, a comprehensive description of the benefits and challenges generated by the polysaccharide-based coatings is provided. Moreover, the latest advances made towards the application of the most important representative coatings based on polysaccharide types for drug delivery are debated. Furthermore, suggestions/recommendations for future research to speed up the transition of polysaccharide-based drug delivery systems from the laboratory testing to clinical applications are given.

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Self‐assembled nanoparticles based on pullulan‐g‐poly(Z‐L‐lysine) for controlled drug delivery: Synthesis, characterization and preliminary studies on the encapsulation of indomethacin

Vieira,

Matos,

Carvalho

et al. 2024

J of Applied Polymer Sci

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Novel biocompatible systems suitable for the controlled release of active ingredients are under the spotlight within the last few years. The present investigation focuses on the preparation of nanoparticles (NPs) based on the amphiphilic copolymer pullulan‐graft‐poly(Z‐L‐lysine) bearing different amounts of lysine (10, 20, and 30 wt%), and on the evaluation of their ensuing viability to encapsulate the hydrophobic nonsteroidal anti‐inflammatory drug indomethacin (INDO). The copolymers are synthesized by ring‐opening polymerization, characterized by NMR and FTIR, and their critical aggregation concentration is determined by fluorescence. The NPs are prepared with and without INDO using different copolymer/solvent ratios and INDO/copolymer ratios. The hydrodynamic diameter and polydispersity of the NP suspensions are monitored by dynamic light scattering for 30 days. Their sizes vary between 208 and 338 nm, and some reach the micrometric range (19–73 μm). INDO‐free NPs are identified as spherical‐shaped by atomic force microscopy. Two formulations are tested in terms of encapsulation efficiency (EE = 43%–89%), and the drug crystallinity (DC = 7%–27%) which is determined by differential scanning calorimetry, indicating a reduction with respect to pristine INDO. The results suggest that the copolymers prepared herewith have potential to be applied as carriers for new drug delivery systems of class II drugs.

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Preparation and characterization of cationic pullulan-based polymers with hydrophilic or amphiphilic characteristics for drug delivery

Cited by 12 publications

References 56 publications

Using RAFT Polymerization Methodologies to Create Branched and Nanogel-Type Copolymers

Using RAFT Polymerization Methodologies to Create Branched and Nanogel-Type Copolymers

Polysaccharide-Based Coatings as Drug Delivery Systems

Self‐assembled nanoparticles based on pullulan‐g‐poly(Z‐L‐lysine) for controlled drug delivery: Synthesis, characterization and preliminary studies on the encapsulation of indomethacin

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