Preparation and characterization of chitosan-hydroxybenzotriazole/polyvinyl alcohol blend nanofibers by the electrospinning technique

Charernsriwilaiwat, Natthan; Opanasopit, Praneet; Rojanarata, Theerasak; Ngawhirunpat, Tanasait; Supaphol, Pitt

doi:10.1016/j.carbpol.2010.03.031

Cited by 105 publications

(61 citation statements)

References 33 publications

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“…It was found that the antitumor efficacy of the DOX-containing mats at 6 h was higher than that of the free DOX. Chitosan/hydroxybenzotriazole(HOBt)/PVA blend nanofibers may be suitable for drug delivery or tissue engineering applications too [117]. For effective cancer gene therapy, systemic administration of tumor-targeting adenoviral (Ad) complexes is critical for delivery to both primary and metastatic lesions.…”

Section: Drug Deliverymentioning

confidence: 99%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

218

101

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Chitosan is soluble in most acids. The protonation of the amino groups on the chitosan backbone inhibits the electrospinnability of pure chitosan. Recently, electrospinning of nanofibers based on chitosan has been widely researched and numerous nanofibers containing chitosan have been prepared by decreasing the number of the free amino groups of chitosan as the nanofibiers have enormous possibilities for better utilization in various areas. This article reviews the preparations and properties of the nanofibers which were electrospun from pure chitosan, blends of chitosan and synthetic polymers, blends of chitosan and protein, chitosan derivatives, as well as blends of chitosan and inorganic nanoparticles, respectively. The applications of the nanofibers containing chitosan such as enzyme immobilization, filtration, wound dressing, tissue engineering, drug delivery and catalysis are also summarized in detail

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Section: Drug Deliverymentioning

confidence: 99%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

218

101

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“…It is also necessary to mention that not only electrospun chitin and chitosan are produced but also chitin derivatives [24,45,46]. …”

Section: Introductionmentioning

confidence: 99%

Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide)

Lemma

Bossard

Rinaudo³

2016

IJMS

102

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Electrospinning was employed to obtain chitosan nanofibers from blends of chitosans (CS) and poly(ethylene oxide) (PEO). Blends of chitosan (MW (weight-average molecular weight) = 102 kg/mol) and PEO (M (molecular weight) = 1000 kg/mol) were selected to optimize the electrospinning process parameters. The PEO powder was solubilized into chitosan solution at different weight ratios in 0.5 M acetic acid. The physicochemical changes of the nanofibers were determined by scanning electron microscopy (SEM), swelling capacity, and nuclear magnetic resonance (NMR) spectroscopy. For stabilization, the produced nanofibers were neutralized with K2CO3 in water or 70% ethanol/30% water as solvent. Subsequently, repeated washings with pure water were performed to extract PEO, potassium acetate and carbonate salts formed in the course of chitosan nanofiber purification. The increase of PEO content in the blend from 20 to 40 w% exhibited bead-free fibers with average diameters 85 ± 19 and 147 ± 28 nm, respectively. Their NMR analysis proved that PEO and the salts were nearly completely removed from the nanostructure of chitosan, demonstrating that the adopted strategy is successful for producing pure chitosan nanofibers. In addition, the nanofibers obtained after neutralization in ethanol-aqueous solution has better structural stability, at least for six months in aqueous solutions (phosphate buffer (PBS) or water).

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“…The diameter gradually decreased with increasing chitosan content in the blend, and more beads were obtained in the blend. This indicates that the repulsive forces between ionic groups in the chitosan backbone obstructed the formation of continuous fiber during electrospinning [19]. Therefore, the morphology and diameter of electrospun fibers were expected to be seriously affected by the volumetric ratio of chitosan/PVA.…”

Section: Determination Of Nanofiber Diameter and Morphologymentioning

confidence: 99%

Characterization of Electrospinning Parameters of Chitosan/Poly(vinyl alcohol) Nanofibers to Remove Phenol via Response Surface Methodology

Ay¹,

Zilouei²,

Sn³

2018

Polym Sci

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Preparation and characterization of chitosan-hydroxybenzotriazole/polyvinyl alcohol blend nanofibers by the electrospinning technique

Cited by 105 publications

References 33 publications

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide)

Characterization of Electrospinning Parameters of Chitosan/Poly(vinyl alcohol) Nanofibers to Remove Phenol via Response Surface Methodology

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