Preparation and characterization of chitosan/whey isolate protein active film containing TiO2 and white pepper essential oil

Wang, Ying; Wang, Ji; Lai, Jin; Zhang, Xin; Wang, Yongliang; Zhu, Y.

doi:10.3389/fnut.2022.1047988

Cited by 2 publications

(1 citation statement)

References 58 publications

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“…According to the results in Table 2, the solubility of the film decreased significantly after the addition of TiO2 nanoparticles. The neat SRC film had the highest solubility compared to the other films, which could be attributed to the abundance of hydrophilic groups in the SRC molecules, particularly -OH and -NH2 [31]. The reduction in the solubility of the composite films can be attributed to the compact structures and strong bonds formed by interactions between TiO2 and the SRC polymer matrix.…”

Section: Physical Properties Of Src Filmsmentioning

confidence: 96%

Fabrication and Characterization of Semi-refined Carrageenan Films Incorporated with TiO2 Nanoparticles

ABD HAMID,

Jayakumar,

Gunasegaran

et al. 2023

JCEIB

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In this study, a packaging film was developed using semi-refined carrageenan, incorporating varying concentrations of TiO2 nanoparticles. The aim of this study was to investigate the effect of TiO2 nanoparticles on the properties of the SRC-based film. The films were prepared through a casting method, and the resulting samples were characterized in terms of their functional, mechanical, and physical properties. The SRC film containing 1 wt% of TiO2 nanoparticles demonstrated the highest tensile strength. However, with the addition of TiO2 nanoparticles at any concentrations (1, 3, 5, and 7 wt%), the elongation at break of the SRC film decreased in comparison to the SRC film without TiO2 nanoparticles. Moreover, as the concentration of TiO2 nanoparticles increased from 1 to 7 wt%, the moisture content, and water solubility of the SRC films decreased. The FTIR spectra analysis provided valuable information on the interaction between SRC and TiO2 nanoparticles. The results suggest that incorporating TiO2 nanoparticles into semi-refined carrageenan films shows promise for developing packaging materials with improved mechanical strength and physical performance.

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Section: Physical Properties Of Src Filmsmentioning

confidence: 96%

Fabrication and Characterization of Semi-refined Carrageenan Films Incorporated with TiO2 Nanoparticles

ABD HAMID,

Jayakumar,

Gunasegaran

et al. 2023

JCEIB

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Development of Polyvinyl Alcohol/Polyethylene Glycol Copolymer-based Orodispersible Films Loaded with Entecavir: Formulation and In vitro Characterization

Wei,

Zhou,

et al. 2024

CDD

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Purpose: The aim of the study is to prepare entecavir (ETV)-loaded orodispersible films (ODFs) using polyvinyl alcohol (PVA)/polyethylene glycol (PEG) graft copolymer (Kollicoat® IR) as a film-forming agent, and further to evaluate the dissolution rate, mechanical and physicochemical properties of films. Methods: ETV-ODFs were prepared by a solvent casting method. The amount of film-forming agent, plasticizer, and disintegrating agent was optimized in terms of the appearance, thickness, disintegration time and mechanical properties of ODFs. The compatibility between the drug and each excipient was conducted under high temperature (60 °C), high humidity (RH 92.5%), and strong light (4500 Lx) for 10 days. The dissolution study of optimal ODFs compared with the original commercial tablet (Baraclude®) was performed using a paddle method in pH 1.0, pH 4.5, pH 6.8, and pH 7.4 media at 37 °C. The morphology of ODFs was observed via scanning electron microscopy (SEM). The mechanical properties such as tensile strength (TS), elastic modulus (EM), and percentage elongation (E%) of ODFs were evaluated using the universal testing machine. The physicochemical properties of ODFs investigated using X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FT-IR). Results: The related substances were less than 0.5% under high temperature, high humidity, and strong light for 10 days when ETV was mixed with excipients. The optimal formulation of ODFs was set as the quality ratio of Kollicoat® IR, glycerol, sodium alginate (ALG-Na): TiO2: MCC+CMC-Na: ETV was 60:9:12:1:1:1. The drug-loaded ODFs were white and translucent with excellent stripping property. The thickness, disintegration time, EM, TS, and E% were 103.33±7.02 μm, 25.31±1.95 s, 25.34±8.69 Mpa, 2.14±0.26 Mpa, and 65.45±19.41 %, respectively. The cumulative drug release from ODFs was more than 90% in four different media at 10 min. The SEM showed that the drug was highly dispersible in ODFs, and the XRD, DSC, and FT-IR results showed that there occurred some interactions between the drug and excipients. Conclusion: In conclusion, the developed ETV-loaded ODFs showed relatively short disintegration time, rapid drug dissolution, and excellent mechanical properties. This might be an alternative to conventional ETV Tablets for the treatment of chronic hepatitis B.

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Preparation and characterization of chitosan/whey isolate protein active film containing TiO2 and white pepper essential oil

Cited by 2 publications

References 58 publications

Fabrication and Characterization of Semi-refined Carrageenan Films Incorporated with TiO2 Nanoparticles

Fabrication and Characterization of Semi-refined Carrageenan Films Incorporated with TiO2 Nanoparticles

Development of Polyvinyl Alcohol/Polyethylene Glycol Copolymer-based Orodispersible Films Loaded with Entecavir: Formulation and In vitro Characterization

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