Preparation and characterization of chitosanates loaded with Brazilian red propolis extract

Nascimento, Ticiano Gomes do; Nascimento, Nataly Miranda do; Ribeiro, Adriana S.; Almeida, Clinston Paulino de; Santos, José Izaías Zacarias dos; Júnior, Irinaldo Diniz Basílio; Calheiros-Silva, Fernanda Geny; Lira, Giselda Macena; Escodro, Pierre Barnabé; Porto, Isabel Cristina Celerino de Moraes; Silva, Valter Alvino da; Dornelas, Camila Braga; Sousa, Jonas dos Santos; Freitas, Johnnatan Duarte de

doi:10.1007/s10973-021-11060-2

Cited by 7 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Red propolis microcapsules presented an MIC of 135.87-271.74 µg/mL for S. aureus and an MIC of 271.74-543.48 µg/mL for P. aeruginosa, while free propolis displayed activity against them in all the concentrations studied (100 and 2000 µg/mL) [73]. It was also reported that the red propolis extract showed inhibition halos greater than those of chitosanate loaded with propolis [74]. This resulted from the lower propolis quantity and gradual release of propolis microcapsules (Figure 5).…”

Section: Discussionmentioning

confidence: 78%

Development, Physicochemical Properties, and Antibacterial Activity of Propolis Microcapsules

Zhang,

Yang,

Tan

et al. 2023

Foods

View full text Add to dashboard Cite

Propolis is a well-known natural antibacterial substance with various biological activities, such as anti-inflammatory and antioxidant activity. However, applications of propolis are limited due to its low water solubility. In this study, propolis microcapsules were developed with a core material of ethanol extract of propolis and shell materials of gum arabic and β-cyclodextrin using a spray-drying technique. The optional processing formula, particle size distribution, morphology, dissolution property, and antibacterial activity of propolis microcapsules were determined. The results showed that the optional processing obtained an embedding rate of 90.99% propolis microcapsules with an average particle size of 445.66 ± 16.96 nm. The infrared spectrogram and thermogravimetric analyses showed that propolis was embedded in the shell materials. The propolis microcapsules were continuously released in water and fully released on the eighth day, and compared to propolis, the microcapsules exhibited weaker antibacterial activity. The minimum inhibitory concentrations (MICs) of propolis microcapsules against Escherichia coli and Staphylococcus aureus were 0.15 and 1.25 mg/mL, and their minimum bactericidal concentrations (MBCs) were 0.3 and 1.25 mg/mL, respectively. This water-soluble propolis microcapsule shows the potential for use as a sustained-release food additive, preservative, or drug.

show abstract

Section: Discussionmentioning

confidence: 78%

Development, Physicochemical Properties, and Antibacterial Activity of Propolis Microcapsules

Zhang,

Yang,

Tan

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

“…In the DTG curve, it is possible to identify the existence of various simultaneous and overlapping mass loss events, without a clear definition of their beginning and end, whose complexity is typical of plant extracts. However, it can be assumed that low-molecularweight substances can evaporate at low temperatures, while more complex substances can evaporate or even decompose at higher temperatures; for example, aromatic phenolic compounds may decompose slowly due to their rigid chemical structures [49,50]. Although the TG/DTG curve of the propolis extract did not give clear insights, the events observed in this work occurred in a temperature range close to the one reported for red propolis (115-620 • C) [49][50][51].…”

Section: Thermal Behavior By Thermogravimetrymentioning

confidence: 99%

“…The preliminary test to assess the toxicity of any material intended to be used for the manufacture of biomedical devices is in vitro cytotoxicity. Once its non-toxicity is proven, the study of its biocompatibility follows [50].…”

Section: Cell Viability Testmentioning

confidence: 99%

Preliminary Study on the Chemical and Biological Properties of Propolis Extract from Stingless Bees from the Northern Region of Brazil

Ferreira,

Souza,

Pereira

et al. 2024

Processes

View full text Add to dashboard Cite

Natural products are historically regarded as the main sources of bioactive compounds to fight the most diverse diseases; among them, propolis deserves to be highlighted due to several biological activities, such as antioxidant, anti-inflammatory, healing, antibacterial and antileishmanial activity. In this study, the antioxidant and antipromastigote activities and the cytotoxicity of propolis of the Scaptotrigona aff. postica stingless bee were evaluated. Propolis extract was analyzed by infrared spectroscopy, thermogravimetry and spectrophotometry for total polyphenols and flavonoid contents. Antioxidant activity was assessed spectrophotometrically by the DPPH, ABTS and FRAP methods, while antipromastigote activity and cytotoxicity were assessed by the MTT assay. The infrared spectra showed the characteristic bands of both phenols and alcohols. The thermogravimetry study revealed two events and thermal stability around 370 °C, while differential scanning calorimetry showed two endothermic events and an exothermic event. Total polyphenol and flavonoid contents were 21.29 ± 0.003 mg/g and 8.17 ± 0.00 mg/g, respectively, and the antioxidant activities identified by the DPPH, ABTS and FRAP methods were 910.09 ± 0.0264 µM Trolox (IC50 18.9 ± 0.01 µg/mL), 859.97 ± 0.0854 µM Trolox (IC50 692 ± 0.01 µg/mL) and 1613.67 ± 0.2610 µM Trolox (IC50 80 ± 0.1 µg/mL), respectively. The satisfactory antioxidant activity of propolis can be related to the high content of phenolic compounds, which adds value to this product and can contribute to the development of meliponiculture in the Brazilian state of Pará. The propolis extract caused a toxic effect on promastigote forms of Leishmania amazonensis at all concentrations tested, with an IC50 value of 1.50 µg/mL and a statistically significant difference compared to the negative control (p < 0.001). These results show that the propolis extract from S. postica bees may be a promising alternative for treatment against promastigote forms of L. amazonensis.

show abstract

“…We have synthesized and characterized a series of modified chitosan derivatives based on red propolis, 39 silver nanoparticles, 40 polyaniline/clay composites 41,42 and dansyl fluorophores 43,44 as materials for exploitation in pharmaceutical, biological, electrochromic device and fluorescence sensing applications. Amongst these, dansyl derivatives aroused considerable interest as materials for latent fingerprint development, 45,46 since they exhibit intense absorption bands in the near UV region and strong fluorescence in the visible region with high emission quantum yields; the synthetic versatility of the sulfonyl group is an additional attraction.…”

Section: Introductionmentioning

confidence: 99%

Dansyl fluorophore functionalized hierarchically structured mesoporous silica nanoparticles as novel latent fingerprint development agents

Oliveira,

da Silva,

Sonsin

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

Preparation and characterization of chitosanates loaded with Brazilian red propolis extract

Cited by 7 publications

References 41 publications

Development, Physicochemical Properties, and Antibacterial Activity of Propolis Microcapsules

Development, Physicochemical Properties, and Antibacterial Activity of Propolis Microcapsules

Preliminary Study on the Chemical and Biological Properties of Propolis Extract from Stingless Bees from the Northern Region of Brazil

Dansyl fluorophore functionalized hierarchically structured mesoporous silica nanoparticles as novel latent fingerprint development agents

Contact Info

Product

Resources

About