Preparation and characterization of cisplatin-incorporated chitosan hydrogels, microparticles, and nanoparticles

Chitosan Microgels and Nanoparticles via Electrofluidodynamic Techniques for Biomedical Applications

“…Hence, the capability of solvents to mediate polymer chain interactions may contribute to influence the on-demand release mechanisms in acidic environmenta. Moreover, their capability to selectively respond to environmental change in vitro or in vivo is mainly related to the large quantities of amino groups on its chains [29] which are able to induce volume phase transitions from swollen to collapsed states or vise versa, with relevant effects on molecular release. Indeed, this peculiar feature is extremely important from applicative point of view, taking into account how drug release capacity of the particles significantly changes from a swollen to a collapsed state as a function of pH, thus rendering chitosan microgels and nanoparticles, particularly promising as carriers in acid microenvironment for oral delivery [30], tissue regeneration [31] and cancer therapy [32].…”

Polymeric drug delivery of platinum-based anticancer agents

“…Encapsulation within a polymer matrix is complex and a few examples have been reported by spray drying,122 by use of physical processes such as partitioning between phases 123, 124 or by conjugation of the drug to the polymer 79–81. The high water solubility of platinum drugs such as cisplatin makes encapsulation within polymeric microparticulates difficult although high drug loadings have been achieved in systems using biocompatible synthetic polymers 73, 79, 122–127 and natural polymers such as albumin 128 hyaluronic acid 129 and chitosan,74, 127, 130–133 all with groups capable of forming complexes with cisplatin (Tab. 4).…”

Miscible Blend and Semi-IPN Gel of Poly(hydroxyethyl aspartamide) with Poly(N-vinyl pyrrolidone)

“…Recently, there has been increasing interest in the use of hydrogels for novel drug and cell delivery and also as tissue engineering scaffold. [5][6][7][8][9][10] Poly(Nvinyl pyrrolidone) (PNVP), a well-known hydrophilic polymer, has many biomedical applications such as a blood plasma extender, a carrier of drug delivery, a modifier for enzymes, and a copolymer in UV-curable bioadhesives due to its many outstanding properties and biocompatibility. 11 In addition, it † To whom correspondence should be addressed.…”