Preparation and characterization of curcumin/chitosan conjugate as an efficient photodynamic antibacterial agent

Zhao, Lingyu; Ding, Xiaowei; Khan, Imran Mahmood; Yue, Lin; Zhang, Yin; Wang, Zhouping

doi:10.1016/j.carbpol.2023.120852

Cited by 25 publications

(11 citation statements)

References 69 publications

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“…2 Free curcumin has good antioxidative properties due to its phenolic hydroxyl groups. 44 To determine the antioxidant activity of the SF/Ag/ C hydrogels, the FRAP assay was conducted. Both the SF hydrogel and the SF/Ag hydrogel showed low free-radical scavenging ability, while curcumin exhibited a relatively high radical scavenging ability (Figure 6A).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Oxidative stress poses another hurdle to the healing of skin wounds. , Excessive generation of reactive species not only causes irreversible damage to biomolecules but also triggers the expression of pro-inflammatory cytokines . Free curcumin has good antioxidative properties due to its phenolic hydroxyl groups . To determine the antioxidant activity of the SF/Ag/C hydrogels, the FRAP assay was conducted.…”

Section: Resultsmentioning

confidence: 99%

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Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

Yan,

Li,

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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Excessive oxidative stress, bacterial infections, and inflammation are the primary factors impeding the healing of skin wounds. Bioactive hydrogels are commonly employed in the treatment of skin injuries. However, the limited solubility of many drugs and active agents in water significantly hampers their effectiveness in hydrogel dressings. In this research, prior to incorporation into the silk fibroin (SF) hydrogel matrix, two active agents curcumin and silver nanoparticles (Ag NPs) were decorated by silk sericin to improve their dispersibility and stability in water. The resultant SF/Ag/C hydrogels combined the biological safety and nontoxicity of SF, the antioxidant and anti-inflammatory efficacy of curcumin, and the antibacterial effect of Ag NPs. These properties effectively enhanced wound repair by reducing bacterial infections, mitigating oxidative stress, suppressing the expression of pro-inflammatory factors, and promoting angiogenesis. This study presented a straightforward approach for constructing bioactive hydrogels for the promotion of the wound healing process.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

Yan,

Li,

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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“…The chemical stability of Lut in the constructed Lut@LYS-HANPs was evaluated based on a previously reported approach. 33 Briefly, freshly prepared Lut@LYS-HANP colloidal dispersion samples (exposed to natural light and room temperature) were extracted at 2, 4, 6, 8, 10, and 14 d. The change in the Lut content was evaluated by using first-order kinetic calculations. The degradation rate kinetic equations for Lut are as follows i k j j j j j y…”

Section: = ×mentioning

confidence: 99%

pH-Driven Self-Assembly of Functional Lysozyme–Hyaluronan Complex Colloidal Nanoparticles for the Oral Delivery of Lutein

Liu,

Li,

Lian

et al. 2024

Crystal Growth & Design

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Despite its various health-promoting bioactivities, poor water solubility, chemical instability, and low bioavailability of lutein have limited its further application in the food industry. This paper reports a simple and a green pH-driven method to synthesize lutein-loaded lysozyme−hyaluronan complex colloidal nanoparticles (Lut@LYS-HANPs) able to overcome the aforementioned shortcomings. The fabricated Lut@LYS-HANPs exhibited a stabilized particle size (164 nm), negative surface zetapotential (−44.86 mV), excellent long-term storage stability, and favorable redispersibility. The encapsulation efficiency and loading ability of lutein in the prepared Lut@LYS-HANPs were 96.23 and 11.07%, respectively. Infrared spectra demonstrated that the dominant interaction forces behind the formed Lut@LYS-HANPs were hydrogen bonds and hydrophobic and electrostatic interactions. The circular dichroism spectra indicated that lutein incorporation mainly changed the α-helix and β-sheet contents of lysozyme. Besides, the

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“…With a specific end goal to design and optimize novel efficient Cur-based wound-healing dressings, it is beneficial to incorporate other polymeric substances such as polyurethane, 13 polysaccharides, 14−16 gelatin, 17 poly(vinyl alcohol), 18 and pluronics 19 into the structures of the Cur-based dressing, which will increase the contribution of Cur in wound healing: for example, mechanically tunable Cur-polyurethane, 13 thiolated Cur-pluronic F127 micelles, 20 Cur-coated magnetic nanoparticles hyaluronic acid, 14 Cur-encapsulated fmoc-grafted chitosan and fmoc peptide hybrid hydrogel, 21 organic− inorganic hybrids of CuS@C p−n junction, 15 arginine-derived carbon quantum dots and polymeric Cur, 22 water-soluble Cur, 23 and esterification reactions. 24 Various strategies have shown promising results in terms of antibacterial performance and enhanced angiogenesis by the sustained release of Cur. It is worth noting (but easily ignored) that most of the Cur-based hydrogels are passive and cannot remold the wound microenvironment, resulting in low utilization of Cur and a poor wound-healing effect.…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing

Fan,

Huang,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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The treatment of diabetic chronic wounds is still faced with great challenges, mainly due to wound infection, excessive inflammation, and peripheral vascular disease in the wound area. Therefore, it is of great importance to develop a novel multifunctional hydrogel with high efficiency to accelerate diabetic wound healing. Curcumin (Cur), a Chinese herbal, has shown great potential in enhancing the healing of diabetic chronic wounds because of its immunomodulatory and pro-angiogenic properties. However, its low aqueous solubility, poor bioavailability, and chemical instability have limited its clinical applications. To address these current bottlenecks, novel poly(vinyl alcohol) (PVA)− chitosan (CS)/sodium alginate (SA)−Cur (PCSA) hydrogels were prepared for the first time, and they demonstrated all of the above intriguing performances by the Michael addition reaction of CS and Cur. PCSA hydrogels show multiple dynamic bonds, which possess strong mechanical properties (tensile stress: ∼0.980 MPa; toughness: ∼258.45 kJ/m 3 ; and compressive strength: ∼7.38 MPa at strain of 80%). These intriguing performances provided an optimal microenvironment for cell migration and proliferation and also promoted the growth of blood vessels, leading to early angiogenesis. Importantly, the experimental results demonstrated that PCSA hydrogels can effectively transform pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages without the need for additional ingredients in vitro. Benefiting from these characteristics, a full-thickness diabetic wound in a rat model demonstrated that PCSA hydrogels can effectively accelerate wound healing via ROS-scavenging, downregulation of IL-1β, and upregulation of CD31 expression, resulting in angiogenesis and collagen deposition. This strategy not only provides a simple and safe Cur-based hydrogel for diabetic wound healing but also highlights the significant potential for the development of high-performance biomaterials for promoting diabetic wound healing using traditional Chinese medicine.

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Preparation and characterization of curcumin/chitosan conjugate as an efficient photodynamic antibacterial agent

Cited by 25 publications

References 69 publications

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

pH-Driven Self-Assembly of Functional Lysozyme–Hyaluronan Complex Colloidal Nanoparticles for the Oral Delivery of Lutein

A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing

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