Preparation and characterization of curcumin/β-cyclodextrin nanoparticles by nanoprecipitation to improve the stability and bioavailability of curcumin

Jiang, Longwei; Xia, Ning; Wang, Fenghui; Xie, Cancan; Ye, Rong; Tang, Hongjie; Zhang, Huajiang; Liu, Yingzhu

doi:10.1016/j.lwt.2022.114149

Cited by 39 publications

(11 citation statements)

References 34 publications

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“…The spectral measurement ranges extend from 40 to 250 • C. Within these ranges, no additional endothermic peaks have manifested. Contrarily, β-CD displayed a large endothermic peak at 113.95 • C, which was associated with the dehydration of β-CD [33,65]. Similar to this, the NICs also produced the same endothermic peak for moisture removal (removal of water molecules) at 142.25 • C. The initial β-CD hydrate and the NICs exhibited comparable behavior, with the exception of the anhydrous β-CD transitioning from a crystalline to an amorphous form at 213.73 • C [66].…”

Section: Thermal Analysis (Dsc Analysis)mentioning

confidence: 99%

Preparation and Characterization of a Nano-Inclusion Complex of Quercetin with β-Cyclodextrin and Its Potential Activity on Cancer Cells

Rajamohan

Ashokkumar

Murugavel³

et al. 2023

Micromachines

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Quercetin (QRC), a flavonoid found in foods and plants such as red wine, onions, green tea, apples, and berries, possesses remarkable anti-inflammatory and antioxidant properties. These properties make it effective in combating cancer cells, reducing inflammation, protecting against heart disease, and regulating blood sugar levels. To enhance the potential of inclusion complexes (ICs) containing β-cyclodextrin (β-CD) in cancer therapy, they were transformed into nano-inclusion complexes (NICs). In this research, NICs were synthesized using ethanol as a reducing agent in the nanoprecipitation process. By employing FT-IR analysis, it was observed that hydrogen bonds were formed between QRC and β-CD. Moreover, the IC molecules formed NICs through the aggregation facilitated by intermolecular hydrogen bonds. Proton NMR results further confirmed the occurrence of proton shielding and deshielding subsequent to the formation of NICs. The introduction of β-CDs led to the development of a distinctive feather-like structure within the NICs. The particle sizes were consistently measured around 200 nm, and both SAED and XRD patterns indicated the absence of crystalline NICs, providing supporting evidence. Through cytotoxicity and fluorescence-assisted cell-sorting analysis, the synthesized NICs showed no significant damage in the cell line of MCF-7. In comparison to QRC alone, the presence of high concentrations of NICs exhibited a lesser degree of toxicity in normal human lung fibroblast MRC-5 cells. Moreover, the individual and combined administration of both low and high concentrations of NICs effectively suppressed the growth of cancer cells (MDA-MB-231). The solubility improvement resulting from the formation of QRC-NICs with β-CD enhanced the percentage of cell survival for MCF-7 cell types.

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Section: Thermal Analysis (Dsc Analysis)mentioning

confidence: 99%

Preparation and Characterization of a Nano-Inclusion Complex of Quercetin with β-Cyclodextrin and Its Potential Activity on Cancer Cells

Rajamohan

Ashokkumar

Murugavel³

et al. 2023

Micromachines

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“…The PDI of GYP was 0.64 ± 0.04, indicating a broad particle size distribution. In contrast, the PDI of CGYP and MGYP was 0.34 ± 0.01 and 0.26 ± 0.01, respectively, indicating high particle homogeneity ( Jiang, et al, 2022 ). The zeta potential is used to measure of the stability of dispersed systems.…”

Section: Resultsmentioning

confidence: 91%

Modulating flavanone compound for reducing the bitterness and improving dietary fiber, physicochemical properties, and anti-adipogenesis of green yuzu powder by enzymatic hydrolysis

Seong,

Kim,

Cho

et al. 2024

Food Chemistry: X

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“…It is worth to note that the initial (0 h) concentrations of EPA/DHA on the apical side were not the same and this could be attributed to the continuously processes of GIT and Caco-2 cell transportation. As such, during this experiment design, the mixed micelles which obtained via the normal order of digestion should be regard as the starting point of transport ( 34 , 35 ). After incubating for 24 h, EPA/DHA contents as TGs and EEs were significantly different compared with 0 h, implying that cell transport had occurred ( Figures 5A, B ).…”

Section: Resultsmentioning

confidence: 99%

Assessment of lipid composition and eicosapentaenoic acid/docosahexaenoic acid bioavailability in fish oil obtained through different enrichment methods

Song

Li²,

Deng³

et al. 2023

Front. Nutr.

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In this study, we analyzed the eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) lipid composition of fish oil obtained through enzymatic treatment, fractional distillation and silica gel column purification, and further assessed EPA/DHA bioavailability. Lipid subclass composition information was obtained through ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS), and bioavailability tests were performed using the Caco-2 cell monolayer model. Results showed that enzymatic treatment improved the incorporation of EPA/DHA as diacylglycerol (DG) while silica gel column chromatography enriched the content of EPA/DHA as phosphatidylglycerol (PG) (12.58%) and phosphatidylethanolamine (PE) (4.99%). Furthermore, increasing the purity of EPA/DHA could improve its bioavailability and after 24 incubation, binding forms of triglyceride (TG) was superior to ethyl ester (EE) (p < 0.05) at the same purity level. Those findings are helpful to provide research basis for exploring the bioactivity of fish oil.

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Preparation and characterization of curcumin/β-cyclodextrin nanoparticles by nanoprecipitation to improve the stability and bioavailability of curcumin

Cited by 39 publications

References 34 publications

Preparation and Characterization of a Nano-Inclusion Complex of Quercetin with β-Cyclodextrin and Its Potential Activity on Cancer Cells

Preparation and Characterization of a Nano-Inclusion Complex of Quercetin with β-Cyclodextrin and Its Potential Activity on Cancer Cells

Modulating flavanone compound for reducing the bitterness and improving dietary fiber, physicochemical properties, and anti-adipogenesis of green yuzu powder by enzymatic hydrolysis

Assessment of lipid composition and eicosapentaenoic acid/docosahexaenoic acid bioavailability in fish oil obtained through different enrichment methods

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