Preparation and characterization of cyclodextrin nanosponges for bortezomib delivery

Allahyari, Saeideh; Valizadeh, Hadi; Roshangar, Leila; Mahmoudian, M.R.; Trotta, Francesco; Caldera, Fabrizio; Jelvehgari, Mitra; Zakeri–Milani, Parvin

doi:10.1080/17425247.2020.1800637

Cited by 28 publications

(21 citation statements)

References 36 publications

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“…Due to increased metabolic activity and limited perfusion, acidic metabolic waste products accumulate in the TME. Cancer and stromal cell activities, their interactions with one another, and their interactions with the extracellular matrix, are all influenced by the acidity of interstitial space and the relatively stable intracellular pH in tumours (Allahyari et al, 2020). Specific characteristics of nanoparticles are needed for adaptation to various biological settings in order to achieve high drug delivery efficiency.…”

Section: Microbiotamentioning

confidence: 99%

Cyclodextrin based nanoparticles for smart drug delivery in colorectal cancer

Marabada,

Li,

Wei

et al. 2023

Chem Biol Drug Des

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The advancement of colorectal cancer (CRC) prevention, detection, and treatment is essential to ensure that survivors live longer and higher‐quality lives. The field of cancer detection and therapy has undergone a revolution with the development of nanotechnology for targeted drug delivery. The significant problems with the delivery of cancer drugs are their solubility, stability, and nonspecific distribution. There is a challenge that the acidic and enzymatic environment in the digestive tract will modify or destroy the medication or the active pharmaceutical ingredient. To overcome the problems, nanoparticles have been widely employed during the past several years to increase the specificity, selectivity, and controlled release of drug delivery systems. The site‐specific and targeted delivery leads to reduce toxicity and side effects. With respect to the capability and utilization of cyclodextrin‐based nanoparticles in different aspects of the tumour microenvironment and gut microbiota, a survey of current research papers was conducted via looking through databases including GoogleScholar, PubMed, Web of Science, and Scopus. This review aims to summarize cutting‐edge nanoparticulate‐based technologies and therapies for CRC.

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Section: Microbiotamentioning

confidence: 99%

Cyclodextrin based nanoparticles for smart drug delivery in colorectal cancer

Marabada,

Li,

Wei

et al. 2023

Chem Biol Drug Des

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“…DSC thermograms often show a reduction/suppression or shift in drug crystalline peaks after encapsulation due to the formation of inclusion complexes. XRD studies show that, in general, crystalline drugs adopt an amorphous form when complexation with the NSs occurs ( Shende P. K. et al, 2015 ; Pushpalatha et al, 2018a ; Allahyari et al, 2020 , 2021 ; Pawar and Shende, 2021 ; Suvarna et al, 2021 ).…”

Section: Applicationsmentioning

confidence: 99%

Cyclodextrin-Based Nanosponges: Overview and Opportunities

et al. 2022

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Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges. Cyclodextrins are cyclic oligomers of glucose derived from starch. The combined external hydrophilicity with the internal hydrophobic surface constitute a unique “microenvironment”, that confers cyclodextrins the peculiar ability to form inclusion host‒guest complexes with many hydrophobic substances. These complexes may impart beneficial modifications of the properties of guest molecules such as solubility enhancement and stabilization of labile guests. These properties complemented with the possibility of using different crosslinkers and high polymeric surface, make these sponges highly suitable for a large range of applications. Despite that, in the last 2 decades, cyclodextrin-based nanosponges have been developed for pharmaceutical and biomedical applications, taking advantage of the nontoxicity of cyclodextrins towards humans. This paper provides a critical and timely compilation of the contributions involving cyclodextrins nanosponges for those areas, but also paves the way for other important applications, including water and soil remediation and catalysis.

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“…The formulations were prepared by polymer condensation, and interfacial phenomenon, and were effective for 6 months at a condition of 40°C and 75% of relative humidity [66]. This type of CD NSs was further used to deliver and increase the activity of several anticancer drugs such as paclitaxel [67], bortezomib [68], flutamide [69], tamoxifen [70], etc. Following their high potential to entrap a variety of molecules, the β-CD/CDI NSs were also used to deliver and improve the solubility and dissolution of paliperidone, an antipsychotic drug for the treatment of schizophrenia [71].…”

Section: Cd-based Polycarbonate Nssmentioning

confidence: 99%

Strategies to Develop Cyclodextrin-Based Nanosponges for Smart Drug Delivery

Hoti¹,

Appleton²,

Pedrazzo³

et al. 2022

Smart Drug Delivery

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In recent years, the development of various cyclodextrin (CD)-based nanosponges (NSs) has gained great importance in the controlled and-or targeted release of drugs due to their versatility and simple preparation. In this chapter, an introduction of different administration routes is explained. Further, different ways to obtain CD-NSs and their classification are shown with a brief explanation of the characterization of the inclusion complexes. Finally, illustrative examples in diverse processes or diseases will be reviewed and explained to demonstrate the potential of CD-NSs. Therefore, this division will serve to compile information on CD-NSs in recent years and to illustrate to readers how to generate and apply different derivatives of interest.

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Preparation and characterization of cyclodextrin nanosponges for bortezomib delivery

Cited by 28 publications

References 36 publications

Cyclodextrin based nanoparticles for smart drug delivery in colorectal cancer

Cyclodextrin based nanoparticles for smart drug delivery in colorectal cancer

Cyclodextrin-Based Nanosponges: Overview and Opportunities

Strategies to Develop Cyclodextrin-Based Nanosponges for Smart Drug Delivery

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