Preparation and characterization of dendronized chitosan/gelatin-based nanogels

Rosso, Anabella Patricia; Martinelli, Marisa

doi:10.1016/j.eurpolymj.2020.109506

Cited by 10 publications

(7 citation statements)

References 69 publications

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“…This approach is a complex process since OTA can react with the -NH 2 groups of Ch, giving rise to different reduced forms of the TA with different numbers of CQO groups. 37 The question arises if the same process occurs when OTA interacts with the -OH moieties of the MNP surface. In order to verify this assumption, the interaction between the MNPs and the crosslinker was first analysed.…”

Section: Resultsmentioning

confidence: 99%

“…The synthesis was carried out using the inverse nanoemulsion technique. 37 Unlike direct emulsion, where a monomer is dissolved in an oil phase that is dispersed in water, in inverse emulsion, the reagents are solubilised in an aqueous phase dispersed in an oil phase. If water dispersion in the oil phase is performed to obtain microdroplets, the method is denoted as inverse nanoemulsion due to the diameter of the formed metastable colloids.…”

Section: Methodsmentioning

confidence: 99%

“…Since the OTA molecule has more than one pyrogallol functionality, the same molecule could react again and generate a crosslinking network. 37,47 Based on those mentioned above, the crosslinking reaction by ultrasonication-assisted inverse nanoemulsion was performed by direct mixing of the pre-emulsions to obtain the hybrid nanogels (see Materials and methods section). Considering that MNPs are functionalised with OTA under oxidising conditions, it is very likely that MNPs@OTA can also act as a crosslinker, as shown in Fig.…”

Section: Characterization Of the Obtained Nanocatalytic Hybrid Nanogelsmentioning

confidence: 99%

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Hybrid nanogels by direct mixing of chitosan, tannic acid and magnetite nanoparticles: processes involved in their formation and potential catalytic properties

Marzini Irranca,

García Schejtman,

Rosso

et al. 2023

Soft Matter

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Characterization Of the Obtained Nanocatalytic Hybrid Nanogelsmentioning

confidence: 99%

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Hybrid nanogels by direct mixing of chitosan, tannic acid and magnetite nanoparticles: processes involved in their formation and potential catalytic properties

Marzini Irranca,

García Schejtman,

Rosso

et al. 2023

Soft Matter

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“…However, gelatin possesses poor thermal stability, so in order to improve its stability, it is generally cross-linked with other polymers (Catoira et al, 2019). Certain favorable properties of gelatin such as good biocompatibility, biodegradability, versatility in crosslinking, easy availability, and economic feasibility have led to numerous studies on the preparation of gelatin-based hydrogels as well as their role in bioactive delivery (Rosso and Martinelli, 2014;Santoro et al, 2014;Aswathy et al, 2020;Rosa et al, 2020).…”

Section: Gelatinmentioning

confidence: 99%

Protein-Based Nanohydrogels for Bioactive Delivery

et al. 2021

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Hydrogels possess a unique three-dimensional, cross-linked network of polymers capable of absorbing large amounts of water and biological fluids without dissolving. Nanohydrogels (NGs) or nanogels are composed of diverse types of polymers of synthetic or natural origin. Their combination is bound by a chemical covalent bond or is physically cross-linked with non-covalent bonds like electrostatic interactions, hydrophobic interactions, and hydrogen bonding. Its remarkable ability to absorb water or other fluids is mainly attributed to hydrophilic groups like hydroxyl, amide, and sulphate, etc. Natural biomolecules such as protein- or peptide-based nanohydrogels are an important category of hydrogels which possess high biocompatibility and metabolic degradability. The preparation of protein nanohydrogels and the subsequent encapsulation process generally involve use of environment friendly solvents and can be fabricated using different proteins, such as fibroins, albumin, collagen, elastin, gelatin, and lipoprotein, etc. involving emulsion, electrospray, and desolvation methods to name a few. Nanohydrogels are excellent biomaterials with broad applications in the areas of regenerative medicine, tissue engineering, and drug delivery due to certain advantages like biodegradability, biocompatibility, tunable mechanical strength, molecular binding abilities, and customizable responses to certain stimuli like ionic concentration, pH, and temperature. The present review aims to provide an insightful analysis of protein/peptide nanohydrogels including their preparation, biophysiochemical aspects, and applications in diverse disciplines like in drug delivery, immunotherapy, intracellular delivery, nutraceutical delivery, cell adhesion, and wound dressing. Naturally occurring structural proteins that are being explored in protein nanohydrogels, along with their unique properties, are also discussed briefly. Further, the review also covers the advantages, limitations, overview of clinical potential, toxicity aspects, stability issues, and future perspectives of protein nanohydrogels.

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“…Thus far, a number of polymers have been applied to build drug delivery systems. The natural polymers, including chitosan [ 11 , 12 ], gelatin [ 13 , 14 ], polylactic acid [ 15 , 16 ], polysiloxane [ 17 , 18 ], collagen [ 19 , 20 ], and alginate [ 21 , 22 ] appeared to be good and useful materials. In addition to these compounds, the synthetic polymers were also used.…”

Section: Introductionmentioning

confidence: 99%

Activity of Povidone in Recent Biomedical Applications with Emphasis on Micro- and Nano Drug Delivery Systems

2021

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Due to the unwanted toxic properties of some drugs, new efficient methods of protection of the organisms against that toxicity are required. New materials are synthesized to effectively disseminate the active substance without affecting the healthy cells. Thus far, a number of polymers have been applied to build novel drug delivery systems. One of interesting polymers for this purpose is povidone, pVP. Contrary to other polymeric materials, the synthesis of povidone nanoparticles can take place under various condition, due to good solubility of this polymer in several organic and inorganic solvents. Moreover, povidone is known as nontoxic, non-carcinogenic, and temperature-insensitive substance. Its flexible design and the presence of various functional groups allow connection with the hydrophobic and hydrophilic drugs. It is worth noting, that pVP is regarded as an ecofriendly substance. Despite wide application of pVP in medicine, it was not often selected for the production of drug carriers. This review article is focused on recent reports on the role povidone can play in micro- and nano drug delivery systems. Advantages and possible threats resulting from the use of povidone are indicated. Moreover, popular biomedical aspects are discussed.

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Preparation and characterization of dendronized chitosan/gelatin-based nanogels

Cited by 10 publications

References 69 publications

Hybrid nanogels by direct mixing of chitosan, tannic acid and magnetite nanoparticles: processes involved in their formation and potential catalytic properties

Hybrid nanogels by direct mixing of chitosan, tannic acid and magnetite nanoparticles: processes involved in their formation and potential catalytic properties

Protein-Based Nanohydrogels for Bioactive Delivery

Activity of Povidone in Recent Biomedical Applications with Emphasis on Micro- and Nano Drug Delivery Systems

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