Preparation and characterization of dextran nanobubbles for oxygen delivery

Cavalli, Roberta; Bisazza, Agnese; Giustetto, Pierangela; Civra, Andrea; Lembo, David; Trotta, G; Guiot, Caterina; Trotta, Michele

doi:10.1016/j.ijpharm.2009.07.010

Cited by 117 publications

(113 citation statements)

References 22 publications

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“…[17][18][19] Recently, there have been some reports regarding the use of microbubbles with special shell reagents for extending the duration of oxygen delivery using ultrasound for local drug delivery. [20][21][22][23][24] However, some problems still need to be resolved, such as the biocompatibility of the shell reagents, microbubble stability, and ultrasonographic damage to the body. Considering the clinical applications for oxygen delivery, an intravenous drip infusion is preferable because infusions possess the flexibility to be administered in large quantities at once and for long periods of time.…”

Section: Introductionmentioning

confidence: 99%

Oxygen supersaturated fluid using fine micro/nanobubbles

Matsuki¹,

Ishikawa²,

Ichiba³

et al. 2014

IJN

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Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.

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Section: Introductionmentioning

confidence: 99%

Oxygen supersaturated fluid using fine micro/nanobubbles

Matsuki¹,

Ishikawa²,

Ichiba³

et al. 2014

IJN

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“…[19][20][21] A large number of studies have reported that UTMD technology promoted the release of many substances inside UCAs or carried by the outer shell, such as chemotherapeutic drugs and genes, to kill tumor cells at a short distance, thus effectively treating tumors. [22][23][24] Other researchers have prepared UCAs using degradable polymer outer shells to encapsulate liquid droplets, which were injected into animals and entered tissue gaps through tumor endothelial gaps. These NBs coalesced into highly echogenic microbubbles to release encapsulated drugs under US irradiation.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of prostate cancer growth using doxorubicin assisted by ultrasound-targeted nanobubble destruction

Fan¹,

Wang²,

Guo³

et al. 2016

IJN

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Ultrasound (US)-targeted microbubble destruction has been widely used as an effective drug-delivery system. However, nanobubbles (NBs) have better stability and stronger penetration than microbubbles, and drug delivery assisted by US-targeted NB destruction (UTND) still needs to be investigated. Our aim was to investigate the effect of doxorubicin (DOX) on the inhibition of prostate cancer growth under UTND. Contrast-enhanced US imaging of transplanted PC3 prostate cancer in mice showed that under a combination of 1 W/cm 2 US power and a 100 Hz intermittent pulse with a “5 seconds on, 5 seconds off” mode, NBs with an average size of (485.7±33) nm were effectively destroyed within 15 minutes in the tumor location. PC3 cells and 20 tumor-bearing mice were divided into four groups: a DOX group, a DOX + NB group, a DOX + US group, and a DOX + NB + US group. The cell growth-inhibition rate and DOX concentration of xenografts in the DOX + NB + US group were highest. Based on another control group and these four groups, another 25 tumor-bearing mice were used to observe the treatment effect of nine DOX injections under UTND. The xenografts in the DOX + NB + US group decreased more obviously and had more cellular apoptosis than other groups. Finally, electron microscopy was used to estimate the cavitation effect of NBs under US irradiation in the control group, NB group, US group, and NB + US group. The results of scanning electron microscopy showed that PC3 cells in the DOX + NB + US group had more holes and significantly increased cell-surface folds. Meanwhile, transmission electric microscopy confirmed that more lanthanum nitrate particles entered the parenchymal cells in xenografts in the NB + US group compared with the other groups. This study suggested that UTND technology could be an effective method to promote drugs to function in US-irradiated sites, and the underlying mechanism may be associated with a cavitation effect.

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“…[18] also the mechanical effects may be detected by inserting contrast agents (e.g. nanobubbles [19]), which can be exploded when the US pressures exceed some threshold values, but no significant differences could be detected in the nanobubbles diameter distribution before and after US sonication. As a consequence, very accurate and anatomically based experimental and numerical models are required to predict the thermal field inside any particular joint or nonhomogeneous body region.…”

Section: Clinical Physical Therapymentioning

confidence: 99%

Therapeutic Ultrasounds: Physical Basis and Clinical Assessment

Lioce¹,

Novello²,

Guiot³

2017

Clinical Physical Therapy

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Improving quality in US physiotherapeutical treatments is mandatory in order to get 'evidence-based' clinical results. This implies quality assurance protocols for the equipment, as well as some tentative dosimetrical approaches to predict local heating in joints following US parameter setting and operative modality. Finally, the possibility of 'personalized therapy' with multimodal (by qualitative and quantitative, e.g. based on sonography) assessment is discussed.

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Preparation and characterization of dextran nanobubbles for oxygen delivery

Cited by 117 publications

References 22 publications

Oxygen supersaturated fluid using fine micro/nanobubbles

Oxygen supersaturated fluid using fine micro/nanobubbles

Inhibition of prostate cancer growth using doxorubicin assisted by ultrasound-targeted nanobubble destruction

Therapeutic Ultrasounds: Physical Basis and Clinical Assessment

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