Preparation and characterization of diamond-like carbon (DLC) film on 316L stainless steel by microwave plasma chemical vapor deposition (MPCVD)

Zhu, Wuyang; Zhi-jun, SU; Guo, Jun; Li, Kang; Chen, Ken; Li, Wenfang; Yi, Aiping; Liao, Zi-Xian; Luo, Youbin; Hu, Yu-Hen; Xu, Yashu; Lin, Quan; Meng, Xinpei

doi:10.1016/j.diamond.2022.108820

Cited by 23 publications

(9 citation statements)

References 31 publications

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“…The Ag/AgCl electrode was prepared by chlorination of the Ag electrode with FeCl 3 solution (0.1 M) 36 . Solid MNs were fabricated by micromilling 316 L stainless steel, which has been widely applied in medical implants, as it shows good mechanical strength and biocompatibility 48 . Polyacrylamide/chitosan vaccine-loaded hydrogels were prepared by UV polymerization and replica molding 49 , 50 .…”

Section: Methodsmentioning

confidence: 99%

Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules

et al. 2023

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COVID-19 has seriously threatened public health, and transdermal vaccination is an effective way to prevent pathogen infection. Microneedles (MNs) can damage the stratum corneum to allow passive diffusion of vaccine macromolecules, but the delivery efficiency is low, while iontophoresis can actively promote transdermal delivery but fails to transport vaccine macromolecules due to the barrier of the stratum corneum. Herein, we developed a wearable iontophoresis-driven MN patch and its iontophoresis-driven device for active and efficient transdermal vaccine macromolecule delivery. Polyacrylamide/chitosan hydrogels with good biocompatibility, excellent conductivity, high elasticity, and a large loading capacity were prepared as the key component for vaccine storage and active iontophoresis. The transdermal vaccine delivery strategy of the iontophoresis-driven MN patch is “press and poke, iontophoresis-driven delivery, and immune response”. We demonstrated that the synergistic effect of MN puncture and iontophoresis significantly promoted transdermal vaccine delivery efficiency. In vitro experiments showed that the amount of ovalbumin delivered transdermally using the iontophoresis-driven MN patch could be controlled by the iontophoresis current. In vivo immunization studies in BALB/c mice demonstrated that transdermal inoculation of ovalbumin using an iontophoresis-driven MN patch induced an effective immune response that was even stronger than that of traditional intramuscular injection. Moreover, there was little concern about the biosafety of the iontophoresis-driven MN patch. This delivery system has a low cost, is user-friendly, and displays active delivery, showing great potential for vaccine self-administration at home.

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Section: Methodsmentioning

confidence: 99%

Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules

et al. 2023

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“…[182] The CVD has different types, such as; plasma-enhanced CVD and microwave plasma CVD. [183] Investigating the HA-coated implants via CVD showed that this sample may have toxic effects on the cells. And the stability of HA-coated showed that this sample has poor adhesion compared with uncoated ones.…”

Section: Cvdmentioning

confidence: 99%

Different methods of hydroxyapatite‐based coatings on external fixator pin with high adhesion approach

Nakhaei

Jirofti

Ebrahimzadeh

et al. 2023

Plasma Processes & Polymers

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“…CVD also includes microwave plasma chemical vapor deposition (MPCVD) and plasma-based ion implantation. The advantages of MPCVD include the lack of pollution, good film-forming quality, and easy operation [1,25,[29][30][31].…”

Section: Deposition Techniques For Dlc Filmmentioning

confidence: 99%

“…Scientists are still working on new methods under the conditions of deposition of diamond-like carbon coatings. Wen Zhu et al [29] deposited DLC films on 316 L stainless steel. In order to improve biocompatibility, they changed parameters such as the temperature, CH4:H2 flow rate, and deposition time in a microwave plasma chemical vapor deposition system.…”

Section: Deposition Techniques For Dlc Filmmentioning

confidence: 99%

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Preparation and Characterization of Diamond-like Carbon Coatings for Biomedical Applications—A Review

2023

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Diamond-like carbon (DLC) films are generally used in biomedical applications, mainly because of their tribological and chemical properties that prevent the release of substrate ions, extend the life cycle of the material, and promote cell growth. The unique properties of the coating depend on the ratio of the sp3/sp2 phases, where the sp2 phase provides coatings with a low coefficient of friction and good electrical conductivity, while the share of the sp3 phase determines the chemical inertness, high hardness, and resistance to tribological wear. DLC coatings are characterized by high hardness, low coefficient of friction, high corrosion resistance, and biocompatibility. These properties make them attractive as potential wear-resistant coatings in many compelling applications, including optical, mechanical, microelectronic, and biomedical applications. Another great advantage of DLC coatings is that they can be deposited at low temperatures on a variety of substrates and can thus be used to coat heat-sensitive materials, such as polymers. Coating deposition techniques are constantly being improved; techniques based on vacuum environment reactions are mainly used, such as physical vapor deposition (PVD) and chemical vapor deposition (CVD). This review summarizes the current knowledge and research regarding diamond-like carbon coatings.

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Preparation and characterization of diamond-like carbon (DLC) film on 316L stainless steel by microwave plasma chemical vapor deposition (MPCVD)

Cited by 23 publications

References 31 publications

Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules

Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules

Different methods of hydroxyapatite‐based coatings on external fixator pin with high adhesion approach

Preparation and Characterization of Diamond-like Carbon Coatings for Biomedical Applications—A Review

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