Preparation and Characterization of Edible Oil Nanoemulsions for Enhanced Stability and Oral Delivery of Curcumin

Abstract

Objective: This work aims to improve the oral bioavailability and long-term aqueous stability of curcumin using various edible oil nanoemulsions (NEs).Methods: NEs were optimized using the water titration method. Curcumin was loaded into optimized emulsions, and the physicochemical characteristics were determined. Long-term stability of curcumin in the edible oil NEs was analyzed by determining the droplet size, PDI and curcumin concentrations over 4 mo. Release of curcumin from the NEs was determined using a Franz diffusion apparatus and analysed using 5 mathematical models.Results: The absorbance of curcumin was linear over the concentration range of 1 to 10 μg. ml-1. The LOD and LOQ ranged from 0.57 to 1.26μg. ml-1 and 1.89 to 4.19μg. ml-1 respectively. All the NEs were monodisperse and had a droplet size less than 150 nm. Long-term emulsion stability shows no change in droplet size and PI (Dunnett's multiple comparisons test with a confidence interval of 95%). Olive oil NE showed significantly low release in gastric fluid (9.28%) with a good release (92.99%) in intestinal fluid and 48% in a body fluid by 8 h.Conclusion: The work highlights the use of olive oil NEs as a delivery vehicle for curcumin with excellent release characteristics and the ability to protect curcumin in an aqueous environment.

In Vivo Characterization of Less Painful Propofol Nanoemulsion Using Palm Oil for Intravenous Drug Delivery

“…Nanoemulsion are one of the dosage form that develop not only for oral route [25,26], topical usage [27] but also populer for parenteral usage like propofol nanoemulsion. Propofol is one of the anesthetic drug that common usage in the hospital but the pain problem make this drug become not comfortable to use.…”

Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—current status and prospects

“…NE can be formulated in three types: (i) oil-in-water nanoemulsion wherein oil is dispersed in the continuous aqueous phase, (ii) water-in-oil nanoemulsion in which water droplets are dispersed in the continuous oil phase, and (iii) bi-continuous nanoemulsion where the microdomains of oil and water are inter-dispersed within the system [ 19 ]. The long-term stability, spontaneous emulsification, extended shelf-life, photostability [ 20 ], and high rate of drug-solubilization capacity makes the MEs/NEs as a potent antimicrobial agent as well as a drug delivery vehicle [ [21] , [22] , [23] , [24] ]. This review aims to highlight the past two years' research findings and patent developments in antiviral NEs, antiviral EOs repurposing, and EO's role in antiviral drug delivery and vaccine formulation with a special focus on SARS-CoV2 infection.…”

Structure and Dynamics of Curcumin Encapsulated Lecithin Micelles: A Molecular Dynamics Simulation Study

“…Despite the fact that curcumin has been developed vastly in nanoemulsion form (Esperón-Rojas et al, 2020;Franklyne et al, 2018;Kamel, 2019;Ningsih et al, 2021;Ochoa-Flores et al, 2017;Páez-Hernández et al, 2019;Shelat and Acharya, 2016;Sholihat et al, 2020;Silva et al, 2018;Teixeira et al, 2016;Yu and Huang, 2012) , study of molecules interaction in curcumin nanoemulsion system is relatively scarce. Simulation studies have been reported on the interaction of curcumin with lipid bilayer (Jalili and Saeedi, 2016;Kopeć et al, 2013) or with inorganic substance (Shi et al, 2019) .…”