Preparation and Characterization of Fe-Gallic acid MOF for determination of antiviral Molnupiravir as inhibitor for RNA Corona virus replication

Younis, Huda M.; Youssef, A.O.; El-Sheikh, Said M.; Sheta, Sheta M.; Attia, Mohamed S.

doi:10.1016/j.microc.2023.109297

Cited by 9 publications

(1 citation statement)

References 81 publications

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“…In the recent literature, various analytical techniques such as high-performance liquid chromatography (HPLC) and reversed-phase HPLC [ 11 , 12 ], liquid chromatography-tandem mass spectrometry (LC–MS-MS) [ 13 – 15 ], ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS–MS) [ 16 – 18 ], high-performance thin-layer chromatography (HP-TLC) [ 17 ], UV–Vis [ 19 ], and fluorescent spectroscopy [ 20 ] have been reported for the quantification of MOL. The spectroscopy has some disadvantages, such as being only possible for analytes containing chromophores, strongly affected by pH, temperature, pollutants, and impurities, limited dynamic range, and lack of fluorescence of each molecule.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of electropolymerization and photopolymerization for the determination of molnupiravir and their application in an electrochemical sensor via computationally designed molecularly imprinted polymers

Cetinkaya,

Unal,

Nazır

et al. 2024

Microchim Acta

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A comparative analysis of molecularly imprinted polymers based on different synthesis techniques was performed for the recognition of molnupiravir (MOL). The polymerizations were performed with 3-thienyl boronic acid (3-TBA) as a functional monomer by electropolymerization (EP) and with guanine methacrylate (GuaM) as a functional monomer by photopolymerization (PP). Morphological and electrochemical characterizations of the developed sensors were investigated to verify the constructed sensors. Moreover, quantum chemical calculations were used to evaluate changes on the electrode surface at the molecular and electronic levels. The dynamic linear range of both designed sensors under optimized experimental conditions was found to be 7.5 × 10−12–2.5 × 10−10 M and 7.5 × 10−13–2.5 × 10−11 M for EP and PP, respectively. The effect of various interfering agents on MOL peak current was assessed for the selectivity of the study. In the presence of 100 times more interfering agents, the RSD and recovery values were determined. The RSD values of GuaM/MOL@MIP/GCE and poly(Py-co-3-PBA)/MOL@MIP/GCE sensors were found to be 1.99% and 1.72%, respectively. Furthermore, the recovery values of the MIP-based sensors were 98.18–102.69% and 98.05–103.72%, respectively. In addition, the relative selectivity coefficient (k′) of the proposed sensor was evaluated, and it exhibited good selectivity for MOL with respect to the NIP sensor. The prepared sensor was successfully applied to determine MOL in commercial serum samples and capsule form. In conclusion, the developed sensors provided excellent reproducibility, repeatability, high sensitivity, and selectivity against the MOL molecule. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%