Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes

Steenis, Jan Hein van; Maarseveen, Erik M. van; Verbaan, F.J.; Verrijk, R.; Crommelin, Daan J.A.; Storm, Gert; Hennink, Wim E.

doi:10.1016/s0168-3659(02)00361-9

Cited by 105 publications

(62 citation statements)

References 26 publications

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“…[21] It has been reported before that the g-activated carboxylic acid group is more accessible and therefore, it reacts more rapidly with NHS thus yielding the gamma-activated derivative. [19,22] According to NMR experiments of NHS-activated FA as well as of the attachment of the shorter ethyleneoxide derivative 3-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-propionic acid tertbutyl ester, mainly functionalization at the g-carboxylic acid group occurred in solution (see Supporting Information), which is in accordance with published procedures. [19,22] Subsequently, about five molecules of (3) were attached to HSA containing about 60 primary amino groups originating from lysine residues in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC).…”

Section: Preparation and Characterization Of Folic Acid Containing Alsupporting

confidence: 78%

Tailored Albumin‐based Copolymers for Receptor‐Mediated Delivery of Perylenediimide Guest Molecules

Eisele

Gropeanu

Musante

et al. 2010

Macromol. Rapid Commun.

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The synthesis of a novel and multifunctional copolymer based on a human serum albumin backbone bearing several folic acid as well as PEO groups was presented. In solution, this side-chain copolymer adopts a globular architecture and about five molecules of the water-insoluble chromophore PDI were successfully incorporated into these micelles for receptor-mediated cell uptake investigations. A significant uptake of these bioconjugates via receptor-mediated endocytosis was detected for cells expressing folic acid receptors in the cell membrane. These novel albumin-based copolymers could serve as efficient and biocompatible carrier systems facilitating the directed delivery of lipophilic drug molecules into cancer cells and they allow investigating vesicle formation and trafficking even at the single molecule level.

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Section: Preparation and Characterization Of Folic Acid Containing Alsupporting

confidence: 78%

Tailored Albumin‐based Copolymers for Receptor‐Mediated Delivery of Perylenediimide Guest Molecules

Eisele

Gropeanu

Musante

et al. 2010

Macromol. Rapid Commun.

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“…121 Higher cytotoxicity of the folatecontaining polyplex by 2.5 times was observed due to increased cellular association of the folate-targeted complex than non-folate polyplexes. Transfection of human ovarian cancer cell line (OVCAR-3) in vitro was distinctly increased compared to untargeted PEGylated polyplexes, implying targeted gene delivery.…”

mentioning

confidence: 94%

Polymeric nanoparticles for targeted treatment in oncology: current insights

Prabhu¹,

Patravale²,

Joshi³

2015

IJN

176

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Chemotherapy, a major strategy for cancer treatment, lacks the specificity to localize the cancer therapeutics in the tumor site, thereby affecting normal healthy tissues and advocating toxic adverse effects. Nanotechnological intervention has greatly revolutionized the therapy of cancer by surmounting the current limitations in conventional chemotherapy, which include undesirable biodistribution, cancer cell drug resistance, and severe systemic side effects. Nanoparticles (NPs) achieve preferential accumulation in the tumor site by virtue of their passive and ligand-based targeting mechanisms. Polymer-based nanomedicine, an arena that entails the use of polymeric NPs, polymer micelles, dendrimers, polymersomes, polyplexes, polymer–lipid hybrid systems, and polymer–drug/protein conjugates for improvement in efficacy of cancer therapeutics, has been widely explored. The broad scope for chemically modifying the polymer into desired construct makes it a versatile delivery system. Several polymer-based therapeutic NPs have been approved for clinical use. This review provides an insight into the advances in polymer-based targeted nanocarriers with focus on therapeutic aspects in the field of oncology.

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“…32 Due to higher reactivity, [33][34][35] the γ-activated carboxyl group of FA might have preferentially reacted with the amino group of NH 2 -β-CD and resulted in the γ-activated derivative under kinetic control. Characterization of the synthesized FA-β-CD is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy

Hong

Sun

et al. 2017

IJN

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Annonaceous acetogenins (ACGs) are a large family of fatty acid derived natural products that are exclusively isolated from the Annonaceae species. Many members of this diverse family have a broad spectrum of biological activities, the most impressive of which is anticancer activity. However, their poor solubility and severe toxicity restrict their clinical application, and their complicated composition hinders their formulation and drug delivery. In this study, β-cyclodextrin was modified with folic acid (FA) and then combined with soybean lecithin to prepare FA-modified ACGs nanosuspensions (FA-ACGs-NSps). The obtained FA-ACGs-NSps had a high drug payload of 57.59% and average particle size of 199.5 nm, and they exhibited sustained drug release within 142 hours. In comparison with ACGs-NSps, FA-ACGs-NSps showed significantly enhanced cytotoxicity and higher cell uptake toward folate receptor-positive 4T1 cell lines. An in vivo study demonstrated that FA-ACGs-NSps more effectively accumulated in tumors and enhanced the antitumor therapeutic efficacy with less toxicity in 4T1 tumor bearing mice. Therefore, FA-ACGs-NSps may be a promising drug delivery system for ACGs to improve their therapeutic window and may be suitable for clinical application to treat folate-positive tumors.

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Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes

Cited by 105 publications

References 26 publications

Tailored Albumin‐based Copolymers for Receptor‐Mediated Delivery of Perylenediimide Guest Molecules

Tailored Albumin‐based Copolymers for Receptor‐Mediated Delivery of Perylenediimide Guest Molecules

Polymeric nanoparticles for targeted treatment in oncology: current insights

Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy

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