Preparation and Characterization of Formaldehyde Crosslinked Chitosan

Abstract

Using formaldehyde as a crosslinking reagena novel cross-linked chitosan resin was synthesized by orthogonal. The resin material with good properties of sphericity and acidresistivity can be prepared under the optimal experimental conditions, which are found to be 1:6 for the ratio of chitosan and formaldehyde, 60°C for the temperature, 1 h for the reaction time, 640r/min for the stirring rate and 9 for the pH, and the cross-linking rate under the optimal conditions is 401.86%. SEM shows the surface morphology changes of raw materials and products; IR of the raw materials and products shows that the reaction occurs mainly on the amino and the hydroxyl of chitosan, and TG shows that the crosslinking reaction of chitosan can change its heat resistance.

Vanillin as a natural cross-linking agent in chitosan-based films: Optimizing formulation by response surface methodology

“…Different cross-linking methods and agents are used depending on the biopolymer and on the extent of improvement in desired properties. Particularly, chemical cross-linking involves the use of chemical agents (such as glutaraldehyde [13], glyoxal [14], formaldehyde [15], and polyaspartic acid and its sodium salt [16]). Nevertheless, these agents may show some undesirable side effects and could be considered as health hazards.…”

Characterization of a Delivery System Based on a Hyaluronic Acid 3D Scaffold and Gelatin Microparticles

“…The degree of crosslinking, together with its positive and negative charges, influences the release kinetics of the encapsulated factors or molecules, as well as the rate of charge [ 23 , 30 , 31 , 32 ]. Traditionally, crosslinking agents like glutaraldehyde, glyoxal, and formaldehyde have been used, despite their associated health hazards related to neurotoxicity and mutagenesis [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Consequently, there is a shift towards their replacement using natural and non-toxic crosslinking agents, such as vanilin and genipin.…”

Vanillin Cross-Linked Chitosan Film with Controlled Release of Green Tea Polyphenols for Active Food Packaging

“…Therefore, cross-linking is often used to reduce the swelling index, overcome poor mechanical and barrier properties, and enhance thermal stability . So far, the cross-linking of chitosan has been most popular with compounds such as glutaraldehyde and citric acid, with only a few studies utilizing vanillin. − Recently, there has been a movement toward the use of naturally derived cross-linkers. For example, quercetin from onion food waste has been used in a number of studies to cross-link chitosan .…”