Preparation and Characterization of Gastroretentive Floating Microspheres of Ofloxacin Hydrochloride

Abstract

As Ofloxacin is preferably absorbed from the upper part of the gastrointestinal tract and is readily soluble in the acidic environment of the stomach, the floating microspheres of ofloxacin were formulated to develop gastroretentive formulation. These floating microspheres release the drug in the stomach and upper gastrointestinal tract and thereby improve the bioavailability. In the present study, six formulations of ofloxacin hydrochloride were prepared as floating microspheres by solvent diffusion technique using polymers such as ethyl cellulose, polyvinyl pyrrolidone K-90 and poly vinyl alcohol in different ratios. The prepared microspheres were evaluated for different physicochemical tests such as particle size, percent drug entrapment, drug content uniformity, SEM, buoyancy test, and in vitro drug release studies. The results of all the physicochemical tests of all formulations were found to be satisfactory. In vitro floatability studies revealed that most of the microspheres (52.5% to 95.5%) were floatable. The in vitro drug release was found to be in the range of 39.64 to 93.64 % at the end of 6 hours. It is concluded that these floating microspheres can be selected for the development of gastroretentive drug delivery system of ofloxacin hydrochloride for potential therapeutic uses.

Development and Evaluation of Gastro Retentive Mucoadhesive Microballoons of Esomeprazole to Treat Peptic Ulcer

“…Flow properties: 19 Carr's index, hausner's ratio, and angle of repose were used to describe the flow characteristics of Esomeprazole Magnesium powder. The Carr's index ((IC)) and Hausner's ratio (HR) of drug powders were calculated using the equations below:…”

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“…Upon dissolution, amine groups of the polymer become protonated, forming a resultant viscous and soluble polysaccharide. Inclusion of citric acid as a pH-regulating excipient in the developed formulations was expected to decrease the micro-environmental pH of the core to a suitable level at which chitosan could form appropriate viscous gelling solution and hence, to enhance the osmotic pressure of core tablets 33 .…”

Preparation and Characterization of Colon-Specific Microspheres of Diclofenac for Colorectal Cancer

“…The loose bulk density (ρb) and the tap (ρt) density of the microspheres were measured in a measuring cylinder [10,18]. An amount of 1 g of prepared microspheres was filled in 10 ml graduated cylinder.…”

“…Microparticles are a type of drug delivery systems where the particle size ranges from one micron to few mm. Microspheres are characteristically free flowing powders consisting of proteins and synthetic polymers, biodegradable in nature and having a particle size less than 200 µm (normally the range is also acceptable up to 1000 -1500 µm) [10].…”