2009
DOI: 10.1016/j.actbio.2009.03.005
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Preparation and characterization of homogeneous chitosan–polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties

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Cited by 237 publications
(130 citation statements)
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“…Another advantage of HAP is that it is biocompatible as implants and provides a biological scaffold for bone formation. However, a disadvantage of pure synthetic HAP is its low load bearing capacity, which can be alleviated somehow by the addition of another material such as polylactide (PLA) and collagen whereby the mechanical properties of the HAP composite biomaterials can be significantly improved [17][18][19]. Many organic and inorganic based composites, such as collagen-HAP, gelatin-HAP (Gel-HAP), Polylactide-HAP composites have been prepared and reported to have significant advantages over pure HAP [20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…Another advantage of HAP is that it is biocompatible as implants and provides a biological scaffold for bone formation. However, a disadvantage of pure synthetic HAP is its low load bearing capacity, which can be alleviated somehow by the addition of another material such as polylactide (PLA) and collagen whereby the mechanical properties of the HAP composite biomaterials can be significantly improved [17][18][19]. Many organic and inorganic based composites, such as collagen-HAP, gelatin-HAP (Gel-HAP), Polylactide-HAP composites have been prepared and reported to have significant advantages over pure HAP [20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…Various biocomposites of calcium orthophosphates with chitosan 298,482,500,512,527,565,[645][646][647][648][649][650][651][652][653]674,675,690,695,799,807,[811][812][813][814][815][816][817][818][819][820][821][822][823][824][825][826][827][828] and chitin 232,476,612,[829][830][831][832][833] are also very popular. For example, a solutionbased method was developed to combine HA powders with chitin, in which the ceramic particles were uniformly dispersed.…”
Section: 725mentioning
confidence: 99%
“…The physicochemical properties of HA nanocrystals prepared in organic polymers is highly dependent on the experimental condition such as pH value and subsequently on the degree of ionization of functional groups of the polymers [8]. Because of the biocompatibility, biodegradability and high mechanical strength of this composite, it was used as tissue scaffold, and in reinforcing applications [9]. Generally, there is several ways to produce such composite materials either by mixing the solid inorganic powder with organic polymer or by preparing in situ preparing the inorganic materials from their ionic precursors in the polymer.…”
Section: Mai K Hassan Et Almentioning
confidence: 99%