Preparation and Characterization of Hydrophilic Polymer Based Sustained-Release Matrix Tablets of a High Dose Hydrophobic Drug

Khan, Niaz Ali; Khan, Amjad; Ullah, Rooh; Ullah, Majeed; Alotaibi, Amal; Ullah, Riaz; Haider, Adnan

doi:10.3390/polym14101985

Cited by 11 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diameter and thickness: 10 tablets were randomly picked from each batch of tablets. Their diameter and thickness 20 were measured using clean vernier calipers (Erweka, Germany). Hardness test: for the hardness test, 10 tablets were chosen at random from each batch of tablets.…”

Section: Methodsmentioning

confidence: 99%

Preparation and In Vitro Evaluation of Levofloxacin-Loaded Floating Tables Using Various Rate-Controlling Agents

Sabei,

Safhi,

Alsalhi

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Floating tablets are a new approach to extending the time a drug is in the stomach to improve therapy outcomes. Floating tablets were formulated with the drug, the polymers hydroxypropyl methylcellulose (HPMC), carboxymethyl cellulose (CMC), and starch, fillers, and lubricants. The tablets were prepared using the direction compression method. The tablets' physical quality control tests were found to be within acceptable limits. The tablets extended drug release up to 12 h and were uniform in their drug contents. The swelling index of the tablets ranged from 60 ± 0.11 to 66 ± 0.14%, and the tablets were less dense than water. The floating lag time (10 ± 0.23 to 16 ± 0.09 s) and total floating time (>12 h) showed good floating behaviors. The kinetic modeling showed that the drug was released from the tablets by pseudo-diffusion, swelling, erosion, or anomalous non-Fickian diffusion. F6 (starch and CMC) showed higher n values (0.994 ± 0.04), exhibiting pseudo-zero-order drug release kinetics compared to those of other tablets. The dissolution data of the test and reference tables were not similar (P > 0.05). In terms of antimicrobial activity, the zones of inhibition of the test F6 tablet powders (5.3 ± 0.08 mm) and the reference tablet powders (5.9 ± 0.13 mm) were found to be significantly similar (P > 0.05). The study concluded that these floating tablets can improve the gastric residence time and therapeutic outcomes.

show abstract

Section: Methodsmentioning

confidence: 99%

Preparation and In Vitro Evaluation of Levofloxacin-Loaded Floating Tables Using Various Rate-Controlling Agents

Sabei,

Safhi,

Alsalhi

et al. 2023

ACS Omega

View full text Add to dashboard Cite

show abstract

“…Overall, f 1 < 15 (0-15) and f 2 > 50 (50-100) indicate comparable dissolution profiles. The dissolution rates of the standard and tested products at a time t are shown by R t and T t , respectively [79,[104][105][106][107][108].…”

Section: Sustained Releasementioning

confidence: 99%

“…Overall, f 1 < 15 (0–15) and f 2 > 50 (50–100) indicate comparable dissolution profiles. The dissolution rates of the standard and tested products at a time t are shown by R t and T t , respectively 79, 104–108.

true f_{1} = \frac{\sum | R_{t} - T_{t} |}{\sum R_{normalt}} \times 100

true f_{2} = 50 \times \log {{[1 + (1 false/ n) \sum {(R_{t} - T_{t})}^{2}]}^{- 0.5} \times 100}

…”

Section: Kinetic Modelingmentioning

confidence: 99%

Kinetic Modeling to Explain the Release of Medicine from Drug Delivery Systems

Askarizadeh,

Esfandiari,

Honarvar

et al. 2023

ChemBioEng Reviews

View full text Add to dashboard Cite

Proper medication dissolution must be ensured when developing or manufacturing a new solid dosage form. Quantitative analyses performed in dissolution or release tests become simpler when applying mathematical formulae which represent dissolution outcomes as a function of several dosage form properties. Methodologies utilized to examine the kinetics of drug release from controlled‐release formulations are reviewed. The analysis of variance was conducted using statistical, model‐independent, and ‐dependent techniques for the dissolution profile comparison and fitting, respectively. Model equations, including zero‐ and first‐order, Hixson‐Crowell, Weibull, Higuchi, Korsmeyer‐Peppas, Baker‐Lonsdale, Hopfenberg, etc., were employed to match the experimental data. Additional release parameters were taken to illustrate the drug release patterns. Using correlation factors and the Akaike information criterion (AIC), the best‐fitting model was discovered, as were the transport phenomena affecting the behavior of the recognized formulations.

show abstract

“…Among the polymer matrices used for the development of oral formulations, the polymeric matrices formed by hydrophilic polymers and their nanocomposites are often used as pharmaceutical excipients due to their low cost and ease of processing. 4,5 Polyvinylpyrrolidone (PVP) is a vinyl polymer that is water-soluble, highly amorphous, inert in the human body, and is normally used as a pharmaceutical excipient, lubricant, and emulsifying agent; It is non-toxic and biocompatible, representing an alternative to the hydrophilic polymer as a matrix. 6,7 Polymer/montmorillonite (MMT) nanocomposites have shown advantages in terms of architecture and morphology formation, such as exfoliation and intercalation.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, considerable research has been conducted to produce nanostructured materials containing inorganic nanofillers dispersed in a polymer matrix. Among the polymer matrices used for the development of oral formulations, the polymeric matrices formed by hydrophilic polymers and their nanocomposites are often used as pharmaceutical excipients due to their low cost and ease of processing 4,5 …”

Section: Introductionmentioning

confidence: 99%

Development of polyvinylpyrrolidone, inorganic nanoparticles, and lithium carbonate nanostructured systems

Farias

Silva

Tavares

et al. 2023

Polymer Engineering & Sci

View full text Add to dashboard Cite

Nanocomposites with inorganic nanofillers spread in a polymer matrix have been used for the development of pharmaceutical systems to treat mental illnesses such as bipolar disorder and Alzheimer's disease. In this study, nanostructured particles using a solution intercalation technique combined with a spray‐drying process using polyvinylpyrrolidone (PVP), montmorillonite, titanium dioxide, and lithium carbonate, with the aim of designing a new drug delivery system. XRD and low‐field nuclear magnetic resonance analyses showed that PVP/MMT 1% achieved an intercalated/exfoliated morphology. However, the incorporation of TiO2 nanoparticles into the PVP matrix did not affect its structure, indicating that there was not a strong interaction between the polymer and the TiO2 nanoparticles. Thermal analysis did not reveal any changes in the nanocomposites compared to the pure polymer. Scanning electron microscopy (SEM) analysis revealed a pseudo‐spherical shape, and SEM‐energy‐dispersive x‐ray spectrometry (EDS) confirmed the dispersion of MMT in the PVP matrix. The introduction of lithium carbonate into the PVP/MMT matrix created a new system with higher molecular mobility; the drug introduction increased the mean droplet size, and the zeta potential remained negative. Overall, the results indicate that the applied methodology can produce a new nanostructured particle as a drug delivery system.

show abstract

Preparation and Characterization of Hydrophilic Polymer Based Sustained-Release Matrix Tablets of a High Dose Hydrophobic Drug

Cited by 11 publications

References 18 publications

Preparation and In Vitro Evaluation of Levofloxacin-Loaded Floating Tables Using Various Rate-Controlling Agents

Preparation and In Vitro Evaluation of Levofloxacin-Loaded Floating Tables Using Various Rate-Controlling Agents

Kinetic Modeling to Explain the Release of Medicine from Drug Delivery Systems

Development of polyvinylpyrrolidone, inorganic nanoparticles, and lithium carbonate nanostructured systems

Contact Info

Product

Resources

About