Preparation and characterization of hydroxyapatite/chitosan-gelatin network composite

Yu, Yin; Zhao, Feng; Song, Xin; Yao, Kang; Lu, William W.; Leong, Jcy

doi:10.1002/1097-4628(20000923)77:13<2929::aid-app16>3.0.co;2-q

Cited by 82 publications

(14 citation statements)

References 28 publications

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“…48 Consequently, the polymer network not only serves as a matrix for the PG and MNPs but also offers an anchoring site for inorganic particles to form a complex structure. 51…”

Section: Resultsmentioning

confidence: 99%

Development of Fe₃O₄ integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

et al. 2020

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“…48 Consequently, the polymer network not only serves as a matrix for the PG and MNPs but also offers an anchoring site for inorganic particles to form a complex structure. 51…”

Section: Resultsmentioning

confidence: 99%

Development of Fe₃O₄ integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

et al. 2020

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“…However, the presence of PDA has been demonstrated in the sample HA/PDA infrared spectra. Therefore, it can be concluded from the above observation that the PLA/HA/PDA composite are successfully synthesized .…”

Section: Resultsmentioning

confidence: 89%

Preparation and properties of polylactide/hydroxyapatite/polydopamine composites

Liu

Zhang

et al. 2018

Polymer Engineering & Sci

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A series of poly(lactic acid)/hydroxyapatite/polydopamine (PLA/HA/PDA) composites were fabricated via soution blending and casting method using CH2Cl2 as solvents. The physicochemical properties of the resulting composites were characterized by Fourier transform infrared spectroscopy, X‐ray powder diffraction, scanning electron microscopy, thermogravimetric analysis, and Rheological analysis. Particularly, the in vitro degradation, hydrophilic of PLA/HA/PDA composites was systematically investigated. The influences of DA content on thermal stabilities, hydrophilic, and rheological behavior properties of composites were evaluated. The results showed that the addition of DA and HA not only improved the thermal stability of PLA, but also improved the hydrophilic of PLA‐based composites. The obtained PLA/HA/PDA composites may be a promising material for load‐bearing orthopedic implants. POLYM. ENG. SCI., 58:2256–2263, 2018. © 2018 Society of Plastics Engineers

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“… 30 FTIR peaks at 1552 cm -1 and 1639 cm -1 definite that new bonds were formed following the interaction of Cs and Gel with the cross-linking reagent (EDC). 34 EDC molecules activate the carboxylic acid functional groups of Gel structure to subsequently interact with amine groups of Cs. 35 A peak at 1321 cm -1 reflects the chemical bond between carboxylic groups of gelatin with Ca ions of nHA, rising the mechanical strength of the scaffold.…”

Section: Discussionmentioning

confidence: 99%

Fabrication, characterization, and optimization of a novel copper-incorporated chitosan/gelatin-based scaffold for bone tissue engineering applications

et al. 2021

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Introduction: Fabricating composite scaffolds with improved physicochemical properties as artificial microenvironments are of great interest in bone tissue engineering. Given advantageous properties of nano-hydroxyapatite/chitosan/gelatin (nHA/Cs/Gel) scaffolds, the present study aimed to synthesize a modified nHA/Cs/Gel biomimetic scaffold with improved features. Methods: Pure and copper (Cu)-substituted nHA was synthesized using the chemical precipitation method under controlled pH and temperature. Pure and Cu-substituted nHA/Cs/Gel scaffolds were fabricated by salt-leaching/freeze-drying method. Physicochemical characteristics of nanoparticles and scaffolds were explored using XRD, FTIR, FE-SEM/EDX, and ICP. Besides, scaffold mechanical strength, degradation, porosity, swelling, biomineralization, and cytocompatibility were assessed. Results: Pure and Cu-substituted nHA were synthesized and characterized with appropriate Cu substitution and improved physical properties. All scaffolds were highly porous (porosity >98%) and Cu incorporation reduced porosity from 99.555 ± 0.394% to 98.69 ± 0.80% while enlarged the pore size to more than100 µm. Cu-substitution improved the scaffold mechanical strength and the best result was observed in nHA.Cu5%/Cs/Gel scaffolds by the compressive strength 88.869 ± 19.574 MPa. Furthermore, 3% and 5% Cu-substituted nHA enhanced the scaffold structural stability and supported osteoblast spread, adhesion, survival, mineralization, and proliferation. Moreover, long-term and sustainable Cu release from scaffolds was observed within 28 days. Conclusion: Cu-substituted nHA/Cs/Gel scaffolds mimic the porous structure and mechanical strength of cancellous bone, along with prolonged degradation and Cu release, osteoblast attachment, viability, calcium deposition, and proliferation. Taken together, our results indicate the upgraded properties of nHA.Cu5%/Cs/Gel scaffolds for future applications in bone tissue engineering.

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Preparation and characterization of hydroxyapatite/chitosan-gelatin network composite

Cited by 82 publications

References 28 publications

Development of Fe₃O₄ integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

Development of Fe₃O₄ integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

Preparation and properties of polylactide/hydroxyapatite/polydopamine composites

Fabrication, characterization, and optimization of a novel copper-incorporated chitosan/gelatin-based scaffold for bone tissue engineering applications

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Preparation and characterization of hydroxyapatite/chitosan-gelatin network composite

Cited by 82 publications

References 28 publications

Development of Fe3O4 integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

Development of Fe3O4 integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

Preparation and properties of polylactide/hydroxyapatite/polydopamine composites

Fabrication, characterization, and optimization of a novel copper-incorporated chitosan/gelatin-based scaffold for bone tissue engineering applications

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Development of Fe₃O₄ integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

Development of Fe₃O₄ integrated polymer/phosphate glass composite scaffolds for bone tissue engineering